Global Advanced Research Journal of Agricultural Science (GARJAS) ISSN: 2315-5094
May 2020 Vol. 9(5): pp. 110-120
Copyright © 2020 Global Advanced Research Journals


Full Length Research Paper

The concentration of toxic metals in teas: A global systematic review, meta-analysis and probabilistic health risk assessment

Fereshteh Mehri1, Maryam Adabi2, Elaheh Talebi Ghane3, Salman Khazaei4*


1Nutrition Health Research Center, Hamadan University of Medical Sciences.

2Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

3 PhD in Biostatistics, Hamadan University of Medical Sciences Hamadan, Iran.

4Research Center for Health Sciences, Hamadan University of medical Sciences, Hamadan, Iran.

*Corresponding Author's Email:

Accepted 13 May, 2020



Background: The tea next to water is the heavily consumed beverage among the world’s population. In current investigation was evaluated the concentration of different metals in teas consumptions through meta-analysis. Methods: The related studies regarding to the concentration of toxic metals in teas were collected from international major databases. A random effect model was used for meta-analysis concentration of Cd, Pb and As in tea among defined subgroups. Results: The mean concentration of toxic metals in the teas was Pb (0.55 mg/kg) > Cd (0.13 mg/kg) > As (0.07 mg/kg), respectively. The highest concentration of metals in green and black tea was related to Pb and As, respectively. Conclusion: Due to the high concentration of metals in different tea samples in many of countries and the health risk for consumersitis need to performing of control plans by governments and farmers for decrease concentration of toxic metals in tea.

Keywords:  Toxic metals, Tea, Concentration, Systematic review, Meta-analysis.







Abbasi S, Farmany A, Gholivand MB, Naghipour A, Abbasi F, Khani H (2009). Kinetic-spectrophotometry method for determination of ultra trace amounts of aluminum in food samples. Food chemistry. 2009;116(4):1019-23.

Al-Othman ZA, Yilmaz E, Sumayli HMT, Soylak M (2012). Evaluation of trace metals in tea samples from Jeddah and Jazan, Saudi Arabia by atomic Absorption Spectrometry. Bulletin of Environmental Contamination and Toxicology. 2012;89(6):1216-9.

Ananthacumaraswamy S, Hettiarachchi L, Dissanayake S (2003). Soil and foliar sulfur status in some tea plantations of Sri Lanka. Communications in soil science and plant analysis. 2003;34(11-12):1481-97.

Antoine JMR, Fung LAH, Grant CN (2017). Assessment of the potential health risks associated with the aluminium, arsenic, cadmium and lead content in selected fruits and vegetables grown in Jamaica. Toxicology Reports. 2017;4:181-7.

Árvay J, Hauptvogl M, Tomáš j, Harangozo L (2015). Determination of mercury, cadmium and lead contents in different tea and teas infusions (Camellia sinensis, L.). Potravinarstvo. 2015;9(1):398-402.

Ashraf W, Mian AA (2008). Levels of selected heavy metals in black tea varieties consumed in Saudi Arabia. Bulletin of Environmental Contamination and Toxicology. 2008;81(1):101-4.

Atamaleki A, Yazdanbakhsh A, Fakhri Y, Mahdipour F, Khodakarim S, Khaneghah AM (2019). The concentration of potentially toxic elements (PTEs) in the onion and tomato irrigated by wastewater: a systematic review; meta-analysis and health risk assessment. Food research international. 2019;125:108518.

Barone G, Giacominelli-Stuffler R, Storelli MM (2016). Evaluation of trace metal and polychlorinated biphenyl levels in tea brands of different origin commercialized in Italy. Food and Chemical Toxicology. 2016;87:113-9.

Başgel S, Erdemoǧlu SB (2006). Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey. Science of the Total Environment. 2006;359(1-3):82-9.

Brown MJ, Margolis S. Lead in drinking water and human blood lead levels in the United States. 2012.

Brzezicha-Cirocka J, Grembecka M, Szefer P (2016). Monitoring of essential and heavy metals in green tea from different geographical origins. Environmental Monitoring and Assessment. 2016;188(3).

Chaoua S, Boussaa S, El Gharmali A, Boumezzough A (2019). Impact of irrigation with wastewater on accumulation of heavy metals in soil and crops in the region of Marrakech in Morocco. Journal of the Saudi Society of Agricultural Sciences. 2019;18(4):429-36.

Chen SL, Li C, Chen AH, Shao Y, Li JW, Liu SB (2015). Editors. Determination of eight metal elements in polygonatum tea by microwave digestion-AAS. Resources, Environment and Engineering - 2nd Technical Congress on Resources, Environment and Engineering, CREE 2015; 2016.

de Oliveira LM, Das S, da Silva EB, Gao P, Gress J, Liu Y (2018). Metal concentrations in traditional and herbal teas and their potential risks to human health. Science of the Total Environment. 2018;633:649-57.

Ensafi AA, Khayamian T, Benvidi A, Mirmomtaz E (2006). Simultaneous determination of copper, lead and cadmium by cathodic adsorptive stripping voltammetry using artificial neural network. Analytica chimica acta. 2006;561(1-2):225-32.

Fakhri Y, Atamaleki A, Asadi A, Ghasemi SM, Mousavi Khaneghah A (2019). Bioaccumulation of potentially toxic elements (PTEs) in muscle Tilapia spp fish: a systematic review, meta-analysis, and non-carcinogenic risk assessment. Toxin Reviews. 2019:1-11.

Falahi E, Hedaiati R (2013). Heavy metal content of black teas consumed in Iran. Food Additives & Contaminants: Part B. 2013;6(2):123-6.

Fernández-Cáceres PL, Martín MJ, Pablos F, González AG (2001). Differentiation of tea (Camellia sinensis) varieties and their geographical origin according to their metal content. Journal of Agricultural and Food Chemistry. 2001;49(10):4775-9.

Ghasemidehkordi B, Malekirad AA, Nazem H, Fazilati M, Salavati H, Shariatifar N (2018). Concentration of lead and mercury in collected vegetables and herbs from Markazi province, Iran: a non-carcinogenic risk assessment. Food and chemical toxicology. 2018;113:204-10.

Gholami Z, Abtahi M, Golbini M, Parseh I, Alinejad A, Avazpour M (2019). The concentration and probabilistic health risk assessment of nitrate in Iranian drinking water: a case study of Ilam city. Toxin reviews. 2019:1-10.

Gomes DAS, Alves JPDS, da Silva EGP, Novaes CG, Silva DS, Aguiar RM (2019). Evaluation of metal content in tea samples commercialized in sachets using multivariate data analysis techniques. Microchemical Journal. 2019;151.

Gomez MR, Cerutti S, Sombra LL, Silva MF, Martínez LD (2007). Determination of heavy metals for the quality control in argentinian herbal medicines by ETAAS and ICP-OES. Food and Chemical Toxicology. 2007;45(6):1060-4.

Hadayat N, De Oliveira LM, Da Silva E, Han L, Hussain M, Liu X (2018). Assessment of trace metals in five most-consumed vegetables in the US: Conventional vs. organic. Environmental Pollution. 2018;243:292-300.

Helgilibrary (2011). Tea ingestion rate. https://wwwhelgilibrarycom/ indicators/onion-consumption-per-capita/india/1–3. 2011.

Heshmati A, Mehri F, Karami-Momtaz J, Khaneghah AM (2020). Concentration and Risk Assessment of Potentially Toxic Elements, Lead and Cadmium, in Vegetables and Cereals Consumed in Western Iran. Journal of Food Protection. 2020;83(1):101-7.

Jin CW, Yun FH, Zhang K, Gen DZ, Jian LS, Zheng SJ (2005). Lead contamination in tea leaves and non-edaphic factors affecting it. Chemosphere. 2005;61(5):726-32.

Jin CW, Zheng SJ, He YF, Zhou GD, Zhou ZX (2995). Lead contamination in tea garden soils and factors affecting its bioavailability. Chemosphere. 2005;59(8):1151-9.

Kaličanin B, Velimirović D (2012). The content of lead in herbal drugs and tea samples. Central European Journal of Biology. 2012;8(2):178-85.

Kamau D, Spiertz J, Oenema O (2008). Carbon and nutrient stocks of tea plantations differing in age, genotype and plant population density. Plant and Soil. 2008;307(1-2):29.

Karak T, Bhagat R (2010). Trace elements in tea leaves, made tea and tea infusion: A review. Food Research International. 2010;43(9):2234-52.

Khaneghah AM, Fakhri Y, Nematollahi A, Pirhadi M (2019). Potentially toxic elements (PTEs) in cereal-based foods: A systematic review and meta-analysis. Trends in Food Science & Technology. 2019.

Lei W, Xing-Lun Y, Rachel K, Yu W, De-Li T, Mao Y (2013). Combined use of alkaline slag and rapeseed cake to ameliorate soil acidity in an acid tea garden soil. Pedosphere. 2013;23(2):177-84.

Li L, Fu QL, Achal V, Liu Y (2015). A comparison of the potential health risk of aluminum and heavy metals in tea leaves and tea infusion of commercially available green tea in Jiangxi, China. Environmental Monitoring and Assessment. 2015;187(5):1-12.

Orisakwe OE, Mbagwu HO, Ukpai P, Udowelle NA (2015). Survey of polycyclic aromatic hydrocarbons and lead in Chinese teas sold in Nigeria: levels and health implications. Roczniki Państwowego Zakładu Higieny. 2015;66(3):225-32.

Li M, Zhang X, Pang G, Han F (2013). The estimation of soil organic carbon distribution and storage in a small catchment area of the Loess Plateau. Catena. 2013;101:11-6.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Annals of internal medicine. 2009;151(4):W-65-W-94.

Lv HP, Lin Z, Tan JF, Guo L (2013). Contents of fluoride, lead, copper, chromium, arsenic and cadmium in Chinese Pu-erh tea. Food Research International. 2013;53(2):938-44.

Mason LH, Harp JP, Han DY (2014). Pb neurotoxicity: neuropsychological effects of lead toxicity. BioMed research international. 2014;2014.

Matsuura H, Hokura A, Katsuki F, Itoh A, Haraguchi H (2001). Multielement determination and speciation of major-to-trace elements in black tea leaves by ICP-AES and ICP-MS with the aid of size exclusion chromatography. Analytical sciences. 2001;17(3):391-8.

Mehri F, Heshmati A, Moradi M, Khaneghah AM (2019). The concentration and health risk assessment of nitrate in vegetables and fruits samples of Iran. Toxin Reviews. 2019:1-8.

Milani RF, Morgano MA, Cadore S (2016). Trace elements in Camellia sinensis marketed in southeastern Brazil: Extraction from tea leaves to beverages and dietary exposure. LWT - Food Science and Technology. 2016;68:491-8.

Mosleh YY, Mofeed J, Almaghrabi OA, Kadasa NM, El-Alzahrani H, Fuller M (2014). Residues of heavy metals, PCDDs, PCDFs, and DL-PCBs some medicinal plants collected randomly from the Jeddah, central market. Life Science Journal. 2014;11(7):1-8.

Naghipour D, Amouei A, Dadashi M, Zazouli MA (2016). Heavy metal content in black tea and their infusions in North of Iran and estimation of possible consumer health risk. Journal of Mazandaran University of Medical Sciences. 2016;26(143):211-23.

Nejatolahi M, Mortazavi S, Ildoromi A (2014). Levels of Cu, Zn, Pb, and Cd in the leaves of the tea plant (Camellia sinensis) and in the soil of Gilan and Mazandaran farms of Iran. Journal of Food Measurement and Characterization. 2014;8(4):277-82.

Nkansah MA, Opoku F, Ackumey AA (2016). Risk assessment of mineral and heavy metal content of selected tea products from the Ghanaian market. Environmental Monitoring and Assessment. 2016;188(6):1-11.

Oh K, Kato T, Xu H (2008). Transport of nitrogen assimilation in xylem vessels of green tea plants fed with NH4-N and NO3-N. Pedosphere. 2008;18(2):222-6.

Özden H, Özden S (2018). Levels of heavy metals and ochratoxin a in medicinal plants commercialized in Turkey. Turkish Journal of Pharmaceutical Sciences. 2018;15(3):376-81.

Piskin MB, Ozdemir OD, Kipcak AS, Tuǧrul N, Derun EM (2013). Some essential element concentrations of Turkish rosehip teas. Advanced Science Letters. 2013;19(11):3148-50.

Podwika W, Kleszcz K (2018). Copper, Manganese, Zinc, and Cadmium in Tea Leaves of Different Types and Origin. 2018;183(2):389-95.

Popović S, Pantelić A, Milovanović Ž, Milinkov J, Vidović M (2017). Analysis of Tea for Metals by Flame and Graphite Furnace Atomic Absorption Spectrometry with Multivariate Analysis. Analytical Letters. 2017;50(16):2619-33.

Prkić A, Jurić A, Giljanović J, Politeo N, Sokol V, Bošković P (2017). Monitoring content of cadmium, calcium, copper, iron, lead, magnesium and manganese in tea leaves by electrothermal and flame atomizer atomic absorption spectrometry. Open Chemistry. 2017;15(1):200-7.

Prkić A, Politeo N, Giljanović J, Sokol V, Bošković P, Brkljača M (2018). Survey of content of cadmium, calcium, chromium, copper, iron, lead, magnesium, manganese, mercury, sodium and zinc in chamomile and green tea leaves by electrothermal or flame atomizer atomic absorption spectrometry. Open Chemistry. 2018;16(1):228-37.

Qin D, Jiang H, Bai S, Tang S, Mou Z (2015). Determination of 28 trace elements in three farmed cyprinid fish species from Northeast China. Food Control. 2015;50:1-8.

Qu C-S, Ma Z-W, Yang J, Liu Y, Bi J, Huang L (2012). Human exposure pathways of heavy metals in a lead-zinc mining area, Jiangsu Province, China. PloS one. 2012;7(11).

Rashid MH, Fardous Z, Chowdhury MA, Alam MK, Bari ML, Moniruzzaman M (2016). Determination of heavy metals in the soils of tea plantations and in fresh and processed tea leaves: an evaluation of six digestion methods. 2016;10:7.

Rezaee R, Hassanzadeh-Khayyat M, Mehri F, Khashyarmanesh Z, Moallemzadeh H, Karimi G (2012). Determination of parathion, aldicarb, and thiobencarb in tap water and bottled mineral water in Mashhad, Iran. Drug and chemical toxicology. 2012;35(2):192-8.

Antoine JM, Fung LAH, Grant CN (2017). Assessment of the potential health risks associated with the aluminium, arsenic, cadmium and lead content in selected fruits and vegetables grown in Jamaica. Toxicology reports. 2017;4:181-7.

Rubio C, Lucas JRD, Gutiérrez AJ, Glez-Weller D, Pérez Marrero B, Caballero JM (2012). Evaluation of metal concentrations in mentha herbal teas (Mentha piperita, Mentha pulegium and Mentha species) by inductively coupled plasma spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2012;71:11-7.

Salahinejad M, Aflaki F (2010). Toxic and essential mineral elements content of black tea leaves and their tea infusions consumed in Iran. Biological trace element research. 2010;134(1):109-17.

Seth TD, Hasan MZ, Sircar S (1973). Lead content of indian tea. Bulletin of Environmental Contamination and Toxicology. 1973;9(2):124-8.

Shaltout AA, Abd-Elkader OH (2016). Levels of Trace Elements in Black Teas Commercialized in Saudi Arabia Using Inductively Coupled Plasma Mass Spectrometry. Biological trace element research. 2016;174(2):477-83.

Sharafi K, Yunesian M, Nodehi RN, Mahvi AH, Pirsaheb M (2019). A systematic literature review for some toxic metals in widely consumed rice types (domestic and imported) in Iran: human health risk assessment, uncertainty and sensitivity analysis. Ecotoxicology and environmental safety. 2019;176:64-75.

Sharafi K, Yunesian M, Nodehi RN, Mahvi AH, Pirsaheb M, Nazmara S (2019). The reduction of toxic metals of various rice types by different preparation and cooking processes–Human health risk assessment in Tehran households, Iran. Food chemistry. 2019;280:294-302.

Shen FM, Chen HW (2008). Element composition of tea leaves and tea infusions and its impact on health. Bulletin of Environmental Contamination and Toxicology. 2008;80(3):300-4.

Shi Y-z, Ruan J-y, Ma L-f, Han W-y, Wang F (2008). Accumulation and distribution of arsenic and cadmium by tea plants. Journal of Zhejiang University SCIENCE B. 2008;9(3):265-70.

Shokrzadeh M, Saberyan M, Saeedi Saravi SS (2008). Assessment of lead (Pb) and cadmium (Cd) in 10 samples of Iranian and foreign consumed tea leaves and dissolved beverages. Toxicological and Environmental Chemistry. 2008;90(5):879-83.

Sofuoglu SC, Kavcar P (2008). An exposure and risk assessment for fluoride and trace metals in black tea. Journal of hazardous materials. 2008;158(2-3):392-400.

Soylak M, Narin I, Divrikli U, Saracoglu S, Elci L, Dogan M (2004). Preconcentration-Separation of Heavy Metal Ions in Environmental Samples by Membrane Filtration-Atomic Absorption Spectrometry Combination. Analytical Letters. 2004;37(4):767-80.

Srogi K (2006). Assessment of selected heavy metal contents in medicinal plants, tea leaves and chocolate using atomic absorption spectrometry. Acta Toxicologica. 2006;14(1-2):117-28.

Szymczycha-Madeja A, Welna M, Pohl P (2012). Elemental analysis of teas and their infusions by spectrometric methods. TrAC trends in analytical chemistry. 2012;35:165-81.

Tokalioǧlu Ş (2012). Determination of trace elements in commonly consumed medicinal herbs by ICP-MS and multivariate analysis. Food Chemistry. 2012;134(4):2504-8.

Tsushida T, Takeo T (1977). Zinc, copper, lead and cadmium contents in green tea. Journal of the Science of Food and Agriculture. 1977;28(3):255-8.

Yaylalı-Abanuz G, Tüysüz N (2009). Heavy metal contamination of soils and tea plants in the eastern Black Sea region, NE Turkey. Environmental Earth Sciences. 2009;59(1):131.

Yongsheng W, Qihui L, Qian T (2011). Effect of Pb on growth, accumulation and quality component of tea plant. Procedia Engineering. 2011;18:214-9.

Zhang HQ, Ni BF, Tian WZ, Zhang GY, Huang DH, Liu CX (2011). Study on essential and toxic elements intake from drinking of Chinese tea. Journal of Radioanalytical and Nuclear Chemistry. 2011;287(3):887-92.

Zhang J, Ma G, Chen L, Liu T, Liu X, Lu C (2017). Profiling elements in Puerh tea from Yunnan province, China. Food Additives and Contaminants: Part B Surveillance. 2017;10(3):155-64.

Zhang J, Yang R, Chen R, Peng Y, Wen X, Gao L (2018). Accumulation of heavy metals in tea leaves and potential health risk assessment: A case study from Puan County, Guizhou Province, China. International Journal of Environmental Research and Public Health. 2018;15(1).

Zhelev I, Barman T, Barooah AK, Goswami BC, Sharma N, Panja S (2019). Contents of Chromium and Arsenic in Tea (Camellia sinensis L.): Extent of Transfer into Tea Infusion and Health Consequence. Scientific reports. 2019.

Zhu F, Wang X, Fan W, Qu L, Qiao M, Yao S (2013). Assessment of potential health risk for arsenic and heavy metals in some herbal flowers and their infusions consumed in China. Environmental Monitoring and Assessment. 2013;185(5):3909-16.

Zhu Y, Duan X, Qin N, Lv J, Wu G, Wei F (2019). Health risk from dietary exposure to polycyclic aromatic hydrocarbons (PAHs) in a typical high cancer incidence area in southwest China. Science of the Total Environment. 2019;649:731-8.







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