Global Advanced Research Journal of Agricultural Science (GARJAS) ISSN: 2315-5094
August 2019 Vol. 8(7): pp. 218-222
Copyright © 2019 Global Advanced Research Journals
Full Length Research Paper
Pharmacokinetics of albendazole and albendazole sulfoxide after oral administration to farm chicken
Tajjiou 1,2 ǀ A. Benjouad 2,3 ǀ M. Oukessou 1
1Hassan II Institute of Agronomy and Veterinary Medicine, Department of Veterinary Biological and Pharmaceutical Sciences, Unit of Physiology and Therapeutics, Rabat, Morocco
2Mohammed V University, Laboratory of Biochemistry and Immunology, Faculty of Sciences, Rabat, Morocco,
3 International university of Rabat, Morocco
*Corresponding Author's Email: SADEK_sanae@hotmail.fr
Accepted 09 May, 2019
The present study was conducted to determine the pharmacokinetic parameters of two anti-parasite drugs: albendazole and albendazole sulfoxide, following oral administration to farm chicken at a single dose of 10 mg/kg body weight. The experiment was done on eight male adult chickens. The HPLC technique was used to determine drug concentrations in plasma. Various pharmacokinetic parameters, including the area under curve (AUC), the maximum plasma concentration (Cmax), the maximum concentration (T max), and the mean residence time (MRT), were determined for both anthelmintics and their metabolites albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO2). The ABZ was detectable up to 32 hours with a maximum plasma concentration Cmax of (0.393-0.557ug/ml) and its metabolites ABZSO and ABZSO2 were detected with a Cmax of (0.393-0.557 ug / ml) and (0.393-0.557ug /ml) with a Tmax of (6.75 , 3.49h) and (16.125-6.59h, respectively. The metabolites of ABZ remain detectable up to 48 hours. The administration of ABZSO to farm chicken showed better bioavailability compared to ABZ. In conclusion, both anthelmintics showed more favorable pharmacokinetic results on farm chicken compared to data collected on broiler chicken.
Keywords: Farm chickens, Albendazole, Single dose, Oral administration, Pharmacokinetics.
Alvarez L, Saumell C, Lanusse C (1996). Plasma disposition kinetics of albendazole metabolites in pigs fed different diets, Research in Veterinary Science, 60, 152-156. https://doi.org/10.1016/S0034 5288(96)90010-7.
Arfaoui T (2000). L’aviculture traditionnelle : caractéristiques, contraintes et voies d’amélioration, cas de la région de khénifra. Mémoire de troisième cycle agronomie, option : productions animales, IAV Hassan II. Rabat, Maroc.
Benchaoui, H.A., Scott, E.W., McKellar, O.A. (1993). Pharmacokinetics of albendazole, albendazole sulfoxide and metobimin in goats, Journal of Veterinary Pharmacology And Therapeutics,16,237-240. https://doi.org/10.1111/j.1365-2885.1993.tb00169.x
Bistoletti M, Alvarez L, Lanusse C, Morena L (2012). disposition kinetics of albendazole and metabolites in laying hens, J vet Pharmacol Therap,36(2),161-168. doi:10.1111/J.1365-2885.01401.x.
Bistoletti M, Morena L, Alvarez L, Lanusse C (2011). Multiresidue HPLC method to measure benzimidazole anthelminthics in plasma and egg from laying hens.Evaluation of albendazole metabolites residues profiles, Food Chemistry,126(2),793-800. doi: 10.1016/j.foodchem.2010.11.084
Bogan JA, Marriner S (1980). Analysis of benzimidazole in body fluids by high performance liquid chromatography. J.Pharmaceut.Sci,69(4),422-423. https://doi.org/10.1002/jps.2600690416
Csiko GY, Banhidi GY, Semjen G, Laczay P, Vanyine SG, Feket J (1996). Metabolism and pharmacokinetics of albendazole after oral administration to chickens,J.Vet.Pharmacol.Therap,19,325-332. https://doi.org/10.1111/j.1365-2885.1996.tb00059.x
El gadari H (2001). Effet de la formulation sur la pharmacocinétique de l’albendazole chez le mouton. Thése de doctorat vétérinaire IAV. Hassan II. Rabat. Maroc
Gibaldi M, Perrier D (1982). Pharmacokinetics. 2nd edition. Dekker M. New York.
Hennessy DR, Stell JW, Lacey E, Eagleson GK, Prichard RK (1989). The disposition of albendazole in Sheep,Journal of veterinary pharmacology and therapeutics,12,421-429. https://doi.org/10.1111/j.1365-2885.1989.tb00693.x
Kichou F, El omari N, Jaouzi T (2002). Prevalence of newcastle disease and infectious bursal disease in morrocan village chickens. In livestock community and environment: the proceedings of the 10th international conference of the association for tropical veterinary medicine, Copenhagen, 189-198.
Marriner SE, Bogan JA (1980). Pharmacokinetics of albendazole in sheep, American Journal of Veterinary Research,41,1126-1129. (PMID:7436109).
Mc kellar QA, Scott EW (1990). The benzimidazole anthelmintic agents: A review, J.Vet.Pharmacol.Therap,13,223-247. https://doi.org/10.1111/j.1365-2885.1990.tb00773.x
Sanchez S, Alvarez L, Lanusse C (1997). Fasting induced changes on the pharmacokinetics behavior of albendazole and its metabolites in cattle, Journal of veterinary pharmacology and therapeutics,20,38-47. https://doi.org/10.1046/j.1365-2885.1997.00810.x
Sanchez S, Sallovitz J, McKellar Q, Lanusse C ( 2000). Comparative availability of two oral dosage forms of albendazole in dogs, Veterinary Journal,160, 153-156. https://doi.org/10.1053/tvjl.2000.0484
Yamaoka K, Tnaigawara Y, Nakagawara T, Uno T (1981). Pharmacokinetics analysis program (MULTI) for microcomputer, J. Pharmacobiodynamics,4(11), 879-85. doi: 10.1248/bpb1978.4.879.
- Tajjiou on Google Scholar
- Tajjiou on Pubmed
- A. Benjouad M. Oukessou on Google Scholar
- A. Benjouad M. Oukessou on Pubmed