Global Advanced Research Journal of Agricultural Science (GARJAS) ISSN: 2315-5094
August 2019 Vol. 8(7): pp. 218-222
Copyright © 2019 Global Advanced Research Journals
Full Length Research Paper
Pharmacokinetics of albendazole and albendazole sulfoxide after oral administration to farm chicken
Tajjiou 1,2 ǀ A. Benjouad 2,3 ǀ M. Oukessou 1
1Hassan II Institute of Agronomy and Veterinary Medicine, Department of Veterinary Biological and Pharmaceutical Sciences, Unit of Physiology and Therapeutics, Rabat, Morocco
2Mohammed V University, Laboratory of Biochemistry and Immunology, Faculty of Sciences, Rabat, Morocco,
3 International university of Rabat, Morocco
*Corresponding Author's Email: SADEK_sanae@hotmail.fr
Accepted 09 May, 2019
The present study was conducted to determine the pharmacokinetic parameters of two anti-parasite drugs: albendazole and albendazole sulfoxide, following oral administration to farm chicken at a single dose of 10 mg/kg body weight. The experiment was done on eight male adult chickens. The HPLC technique was used to determine drug concentrations in plasma. Various pharmacokinetic parameters, including the area under curve (AUC), the maximum plasma concentration (Cmax), the maximum concentration (T max), and the mean residence time (MRT), were determined for both anthelmintics and their metabolites albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO2). The ABZ was detectable up to 32 hours with a maximum plasma concentration Cmax of (0.393-0.557ug/ml) and its metabolites ABZSO and ABZSO2 were detected with a Cmax of (0.393-0.557 ug / ml) and (0.393-0.557ug /ml) with a Tmax of (6.75 , 3.49h) and (16.125-6.59h, respectively. The metabolites of ABZ remain detectable up to 48 hours. The administration of ABZSO to farm chicken showed better bioavailability compared to ABZ. In conclusion, both anthelmintics showed more favorable pharmacokinetic results on farm chicken compared to data collected on broiler chicken.
Keywords: Farm chickens, Albendazole, Single dose, Oral administration, Pharmacokinetics.
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