Global Advanced Research Journal of Educational Research and Reviews (GARJERR) ISSN: 2315-5132

January 2016, 5(1): pp. 009-012

Copyright © 2016 Global Advanced Research Journals

 

Review

Effect of Combined Albendazole and Sutrim in Experimental Toxoplasmosis

Nevine Griguis1, Soheir Mohmoud1, Rabab Zalat1, Mona Magdy2 and Eman Ali1

1Parasitology and 2Pathology, Department Theodor Bilharz Research Institute, Imbaba, Cairo Egypt.

Corresponding Author Email: nevinenessim@hotmail.com

Accepted 04 January, 2016

Abstract

This work is a trial to elucidate the prophylactic effect of a combination of a broad spectrum antihelmintic: Albendazole, and sutrim (Sulphame- thoxazole +Trimethoprin ) on experimental Toxoplasma gondű infection. A group of 20 female albino rats were infected orally with 50 toxoplasma trophozoites per rat. This group was further subdivided into four subgroups: subgroup I constituted infected control rats given 50 Toxoplasma trophozoites / rat orally, then sacrificed two months later. Subgroup II: animals infected with 50 Toxoplasma trophozoites/rat 24 hours after being treated with one third the dose of albendazole orally/rat (0.4 mgm). Sacrifice was done two months later. Subgroup III: Infected rats given the same infective dose 24 hours after being treated with combined Trimethoprim and Sulphamethoxazole 1.2mgm orally/rat. Sacrifice was done two months later. Subgroup IV: Infected rats with 50 trophozoites per rat, after being given half the doses of both drugs orally: 0.2 mgm Albendazole + 0.6 mgm sutrim (Sulphamethoxazole+ Trimethoprim). Again, animals were sacrificed two months post infection. In all animal treated groups, treatment was initiated 24 hours prior to infection. Parasitological count of the Toxoplasma organisms was done in Hx & Eosin and Giemsa stained brain and liver tissues. It was found that animals given the combination regimen revealed less parasite count in the liver and brain tissue (7.14+3.94) and (14.17+4.83) respectively, when compared to the infected untreated control group. Pathological staining of the liver and brain of these rats revealed diminution of the parasitic count in respect to the control infected untreated group (26.79+7.02) and (72.61+7.69) respectively . This study may be in value in endemic areas where drug resistance to the usual anti-Toxoplasma compounds may be commonly encountered.

Keywords: Albendzole, Trimethoprim, Sulphamethoxze, Experimental toxoplasmosis, parasitological examination, Histopathological examination, Sutrim (Spiramycin).

Related Articles


Original Research Articles
Denny Widaya Lukman, Mirnawati Bachrum Sudarwanto, Trioso Purnawarman, Hadri Latif, Herwin Pisestyani, Eddy Sukmawinata and Ömer Akineden
CTX-M-1 and CTX-M-55 Producing Escherichia coli Isolated from Broiler Feces in Poultry Slaughterhouse, Bogor, West Java Province
Glo. Adv. Res. J. Educ. Res. Rev. December 2016 Vol: 5(12): - [Abstract] [Full Text - PDF] (114 KB)
Iroha Ifeanyichukwu, Ikeagwu Ifeoma, Ejikeugwu Chika, Nwakaeze Emmanuel, Eze Egwu, Alu-OKafor Florence, Ugbo Emmanuel, Ikechukwu Moses and Nwuzo Agabus
Prevalence and antibiogram of Pathogenic Gram Negative Bacteria Isolated from patients Seeking Medical Care in a Tertiary Hospital in Abakaliki, Nigeria
Glo. Adv. Res. J. Educ. Res. Rev. October 2015 Vol: 4(10): - [Abstract] [Full Text - PDF] (115 KB)
Case Report
Nishi Sonkhya, Payal Mittal, Divij Sonkhya and Raghav Mehta
Localized laryngeal amyloidosis: A case report and review of literature
Glo. Adv. Res. J. Educ. Res. Rev. April 2012 Vol: 1(3): - [Abstract] [Full Text - PDF] (0 KB)
Original Research Articles
Tsado DN, Adama TZ, Dikko HA, Ishiaku YM and SU Oyibo
Water Intake and Influence of Ambient Temperature on Carcass Characteristics of Savannah Brown Goats Fed Graded Levels of Maize Cob Diets Supplemented With Cowpea Husk
Glo. Adv. Res. J. Educ. Res. Rev. February 2015 Vol: 4(2): - [Abstract] [Full Text - PDF] (154 KB)
Tahia H Saleem, Hamdy N Eltalawy, Ahmed E Ahmed, Nagla H Abu-faddan, Nahed A Mohamed, Ayat A Sayed, Yasser Gamal and Mohammed H Hassan
Glycogen storage disease type-I among pediatric patients in Upper Egypt
Glo. Adv. Res. J. Educ. Res. Rev. October 2014 Vol: 3(10): - [Abstract] [Full Text - PDF] (0 KB)
Hana M Gashlan and Asma B Al-Beladi
Effects of Clove Oil on Liver and Antioxidant Status of Streptozotocin-Induced Diabetic Rats
Glo. Adv. Res. J. Educ. Res. Rev. June 2017 Vol: 6(6): - [Abstract] [Full Text - PDF] (853 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Nevine Griguis1 on Google Scholar
Nevine Griguis1 on Pubmed
Soheir Mohmoud1 on Google Scholar
Soheir Mohmoud1 on Pubmed
Rabab Zalat1 on Google Scholar
Rabab Zalat1 on Pubmed
Mona Magdy2 on Google Scholar
Mona Magdy2 on Pubmed
Eman Ali1 on Google Scholar
Eman Ali1 on Pubmed

Statistics

Viewed 1383
Printed 338
Downloaded 1117
Powered By iPortal Works