Global Advanced Research Journal of Educational Research and Reviews (GARJERR) ISSN: 2315-5132

February 2020, 9(2): pp. 009-013

Copyright © 2020 Global Advanced Research Journals


Full Length Research Paper

Evaluation of the therapeutic effect of some natural plant extracts on experimental cryptosporidiosis 

Hagar Abdel Maksoud(1),   Hoda  Sabry(1),  Soheir Mahmoud(1), Nevine Guirguis (1), Rabab S. Zalat (1) Wafaa EL Komy(1) , and Shaimaa El-Gohary(2).

(1)Parasitology Department, Theodor Bilharz Research institute, Imbaba, Egypt. (2)Medical Pathology, Faculty of Medicine, Ain Shams University.

Corresponding Author Email:    

Accepted 03 February, 2020


Cryptosporidium parvum (C. parvum) is a coccidian protozoon causing cryptosporidiosis, a parasitic disease of the mammalian intestinal tract. It is considered to be the most important waterborne diarrhoeic pathogen in developing countries. Infection causes drastic and retractable diarrhoea with dehydration. But unfortunately, this protozoon resists all levels of chlorination ever-known. The present work aims at evaluating the effect of both naural extracts: lauric acid (monolaurin or coconut), and ginger in C. parvum infected mice. Fifty laboratory bred albino mice were used in the experiment. Animals were divided into 5 groups: Group 1: infected treated with Lauric acid. Group 2: infected treated with ginger. Group 3: infected given combined half doses of both Lauric acid and ginger. Group 4: infected treated with Nitazoxanide antiparasitic drug (infected treated control). Group 5: infected untreated control. Drugs were given for seven consecutive days, followed by sacrifice of all mice. Stool samples were collected for oocysts count. In addition, histopathological examination of upper part of the small intestine was done, and the duodenal contents were examined for oocysts count. There was a significant reduction in C. parvum oocysts count following treatment. The highest percentage of reduction was noticed in the Nitazoxanide treated group (96.7%), followed by Lauric acid (92.5%), followed by the combined treated group (84.4%).  At last, came the Ginger treated group (72.3%). Histopathological examination revealed complete healing of intestinal mucosa after nitazoxanide treatment, while partial healing of the lining intestinal epithelium was noticed after lauric acid, ginger and combined treatment. In conclusion, this study showed that Lauric acid (monolaurin) or coconut offers an alternative or concurrent therapy to the conventional anti- cryptosporidial drugs. The best cure rates were obtained following treatment with Nitazoxanide followed by Lauric acid.

Keywords: Cryptosporidium, Mice, Lauric acid, Nitazoxanide, Coconut, Ginger.

Related Articles

Original Research Article
Mukhtar, La Hatani, Achmad Selamet Aku, Deki Zulkarnain, Dasmin Sidu, La Ode Geo, and La Ode Santiaji Bande
Development of Economic Potential an integrated coconut processing to Improve Welfare coconut farmers society in North Buton Regency
Glo. Adv. Res. J. Educ. Res. Rev. November 2015 Vol: 4(11): - [Abstract] [Full Text - PDF] (167 KB)
Systematic Review
Tabinda Hasan and Kavitha Ganesh
Genetic regulators of Achilles tendon pathogenesis and outcomes
Glo. Adv. Res. J. Educ. Res. Rev. December 2018 Vol: 7(10): - [Abstract] [Full Text - PDF] (365 KB)
Original Research Articles
Wafaa El-komy1, Soheir Mahmoud1, Hoda Sabry1, Soheir Mansy2 and Nevine Guirguis1
Changes in parasitic load, phagocytosis and ultra-structural pattern in experimental cryptosporidiosis following combined (Antox and Nitazode) treatment
Glo. Adv. Res. J. Educ. Res. Rev. March 2016 Vol: 5(3): - [Abstract] [Full Text - PDF] (3,544 KB)
Tugbobo OS, Abegunde SM and Idowu KS
Protection by Dialium indium (Fruit) against Pb2+-Induced Microcytic Anemia and Chromosome Aberration in Albino Rats In Vivo
Glo. Adv. Res. J. Educ. Res. Rev. October 2018 Vol: 7(8): - [Abstract] [Full Text - PDF] (85 KB)
Hana M Gashlan and Asma B Al-Beladi
Effects of Clove Oil on Liver and Antioxidant Status of Streptozotocin-Induced Diabetic Rats
Glo. Adv. Res. J. Educ. Res. Rev. June 2017 Vol: 6(6): - [Abstract] [Full Text - PDF] (853 KB)
Rumyantsev SN
Invasion and parasite subsistence of human cancer
Glo. Adv. Res. J. Educ. Res. Rev. November 2018 Vol: 7(9): - [Abstract] [Full Text - PDF] (389 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Hagar Abdel Maksoud on Google Scholar
Hagar Abdel Maksoud on Pubmed
Hoda Sabry on Google Scholar
Hoda Sabry on Pubmed
Soheir Mahmoud on Google Scholar
Soheir Mahmoud on Pubmed
Nevine Guirguis on Google Scholar
Nevine Guirguis on Pubmed
Rabab S. Zalat on Google Scholar
Rabab S. Zalat on Pubmed
Wafaa EL Komy on Google Scholar
Wafaa EL Komy on Pubmed
Shaimaa El-Gohary on Google Scholar
Shaimaa El-Gohary on Pubmed


Viewed 644
Printed 55
Downloaded 142
Powered By iPortal Works