Global Advanced Research Journal of Environmental Science and Toxicology (GARJEST) ISSN: 2315-5140
March 2016 Vol. 5(2), pp. 009-015
Copyright © 2016 Global Advanced Research Journals

 

Full Length Research Paper

Assessment of Lycium Barbarum for detoxification of Patulin toxin and their effects on rat serum globulin

Nagwa M. El-Sawi1*, Asma S. Abdo1, M.A.A. Mohamed1, H. Salah1, Madeha N. Al Seeni2 and Mohamed T. El-Wassimy1

1Chemistry Department, Faculty of Science, Sohag University,Sohag, 82524, Egypt
2Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, KSA

*Corresponding Author E-mail: elsawinagwa@yahoo.com 

Accepted 31 March, 2016 

Abstract

The aim of this study was to show the efficiency of Goji extract on rat serum globulins which treated with patulin mycotoxin. 50 adult albino male rats were divided into 5 groups. Control group was injected subcutaneously daily with distilled water; groups I and II were injected subcutaneously daily with Patulin (0.2 mg/kg/day) for one and two weeks respectively. Group III was treated with an equal dose of patulin for two weeks then injected subcutaneously with Goji extract (2ml/kg /day) for two weeks. Group IV was treated by Goji for two weeks then they were treated with an equal dose of patulin for two weeks. The mean values of albumin level in treated groups with patulin showed highly significant decrease compared with control group. But the mean values of α1, α2, β and γ globulins showed highly significant increase in GI and G II compared with control group. However there is no significant change in the mean value of albumin, α1, α2, β and γ globulins in G III and G IV compared with the control.  

Keywords: Patulin, Goji extract, Scopoletin, electrophoresis       

 

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