Gobal Advanced Research Journal of Environmental Science and Toxicology
July 2012 Vol. 1(4), pp. 066-071
Copyright © 2012 Global Advanced Research Journals

 

Full Length Research Paper

Antioxidant role of folic acid against reproductive toxicity of cyhalothrin in male mice

Hussein H.K*1, 2, Elnaggar M.H1, 3 and Al-Zahrani N.K1

1Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
2Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.
3Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt.

*Corresponding  Author  E-mail: ahssan555@yahoo.com

Accepted 15th May, 2012

Abstract

The acute toxicity (LD50) of insecticide Cyhalothrin and its effects on male reproduction in rats were carried out. Cyhalothrin was given orally to male rats daily for 30 successive days at two doses (0.1 and 1.0 mg kg_1 b.wt., corresponding to 1/100 and 1/10 LD50) alone and in combination with folic acid (1.1 mg kg_1 b.wt., corresponding to acceptable daily intake, ADI). Fertility index, weight of sexual organs, and histopathology of testes were the parameters used to evaluate the reproductive efficiency of treated rats. The reversibility of Cyhalothrin effects was also studied after 30 days post-administration. The oral LD50 of Cyhalothrin was 20.0 mg kg_1 b.wt. in male rats. Cyhalothrin significantly decreased the fertility index and weight of testes. It induced testicular lesions characterized by moderate to severe degenerative changes of seminiferous tubules and incomplete arrest of spermatogenesis. These toxic effects were not persistent (reversible). Co-administration of folic acid with Cyhalothrin decreased its reproductive toxicity. A great attention should be taken during field application of Cyhalothrin to avoid its deleterious effects in farm animals and occupationally exposed humans.

Keywords: Antioxidants, Cyhalothrin, Reproductive efficiency, Folic acid, Mice

 

Related Articles


Original Research Articles
Rumyantsev SN
Invasion and parasite subsistence of human cancer
Glo. Adv. Res. J. Environ. Sci. Toxicol. November 2018 Vol: 7(9): - [Abstract] [Full Text - PDF] (389 KB)
Imam AA Mekkawy, Usama M Mahmoud and Rehab H Mohammed
Protective effects of tomato paste and Vitamin E on Atrazine-Induced Hematological and biochemical characteristics of Clarias gariepinus (Burchell,1822)
Glo. Adv. Res. J. Environ. Sci. Toxicol. January 2013 Vol: 2(1): - [Abstract] [Full Text - PDF] (228 KB)
Ahmed IA, Kiyawa SA, Maryam TA, Kutama AS and Isah IB
Effects of Pre-harvest application of Lamda-cyhalothrin and Neem Seed Extracts in the management of Cowpea bruchid, Callosobruchus maculatus Fab.(Coleoptera:Bruchidae) on stored cowpea.
Glo. Adv. Res. J. Environ. Sci. Toxicol. March 2014 Vol: 3(3): - [Abstract] [Full Text - PDF] (145 KB)
Kandil A.A., A.E. Sharief and Marwa S. Ahmed
Seed Germination Characters of New and Aging Seed of Some Maize Hybrids as Influenced by Antioxidant and Growth Hormones
Glo. Adv. Res. J. Environ. Sci. Toxicol. March 2019 Vol: 8(3): - [Abstract] [Full Text - PDF] (1,683 KB)
A.A. Kandil, A.E. Sharief and Marwa H.S. Ahmed
Effect of Antioxidant and Growth Hormones on Seedling Parameters of New and Aging Seed of Some Maize Hybrids
Glo. Adv. Res. J. Environ. Sci. Toxicol. March 2019 Vol: 8(3): - [Abstract] [Full Text - PDF] (1,129 KB)
Soad Ismail, Soheir Mahmoud, Hoda Sabri, Nevine Guirguis, Rabab Zalat and Wafaa El-komi
Comparative effect of Praziquantel and Mefloquine in Murine Schistosomal Resistance to Reinfection with Regards to Serum IL-4, IL-5 and IL-10 profiles
Glo. Adv. Res. J. Environ. Sci. Toxicol. November 2019 Vol: 8(1): - [Abstract] [Full Text - PDF] (1,025 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Hussein HK on Google Scholar
Hussein HK on Pubmed
Elnaggar MH on Google Scholar
Elnaggar MH on Pubmed
Al-Zahrani NK on Google Scholar
Al-Zahrani NK on Pubmed

Statistics

Viewed 1993
Printed 438
Downloaded 1627
Powered By iPortal Works