Gobal Advanced Research Journal of Environmental Science and Toxicology (GARJEST) ISSN: 2315-5140
September 2012 Vol. 1(6), pp. 143-151
Copyright © 2012 Global Advanced Research Journals


Full Length Research Paper

4-Nonylphenol induced morphological and histopathological malformations in Bufo regularis tadpoles

Alaa El-Din H. Sayed1*, Sara S. Abdel Hakeem1, Usama M. Mahmoud1 and Imam A. Mekkawy2

1Department of Zoology, Faculty of Science, Assiut University, Assiut, Egypt.
2Department of Biology, Faculty of Science, Taif University, Taif, Saudi Arabia.

*Corresponding   Author   E-mail:   alaa_h254@yahoo.com; Tel:+020882412381, Fax:+020882342708

Accepted 03 September, 2012


Global decline in frog populations is thought to indicate environmental damage caused by human activity. Pollution especially chemicals are found to contaminate aquatic ecosystems and their animals including fish and amphibians during their adult life and sensitive stages of development. Nonylphenol ethoxylate (NPE) is one of the most dangerous chemicals that are recorded in aquatic environments, bacterial degradation of nonylphenol ethoxylates produces more toxic nonylphenol (NP) which is estrogenic both on vitro and vivo assays. In present work, the exposure of embryos of Egyptian toad Bufo regularis to different sublethal doses of 4-nonylphenol (1.5, 2.5, and 3.5 µgl-1) resulted in mortality rate increase and as a result some morphological malformations with histopathological changes in some organs were revealed. This study indicated the destructive effects of 4-Nonylphenol on the tadpoles of Egyptian toad.

Keywords: 4-Nonylphenol; malformations; histopathology, tadpoles; Bufo regularis


Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Alaa El-Din H Sayed on Google Scholar
Alaa El-Din H Sayed on Pubmed
Sara S Abdel Hakeem on Google Scholar
Sara S Abdel Hakeem on Pubmed
Usama M Mahmoud on Google Scholar
Usama M Mahmoud on Pubmed
Imam A Mekkawy on Google Scholar
Imam A Mekkawy on Pubmed


Viewed 2703
Printed 1055
Downloaded 1901
Powered By iPortal Works