Gobal Advanced Research Journal of Environmental Science and Toxicology (GARJEST) ISSN: 2315-5140
September 2012 Vol. 1(6), pp. 143-151
Copyright © 2012 Global Advanced Research Journals
Full Length Research Paper
4-Nonylphenol induced morphological and histopathological malformations in Bufo regularis tadpoles
Alaa El-Din H. Sayed1*, Sara S. Abdel Hakeem1, Usama M. Mahmoud1 and Imam A. Mekkawy2
1Department of Zoology, Faculty of Science, Assiut University, Assiut, Egypt.
2Department of Biology, Faculty of Science, Taif University, Taif, Saudi Arabia.
*Corresponding Author E-mail: email@example.com; Tel:+020882412381, Fax:+020882342708
Accepted 03 September, 2012
Global decline in frog populations is thought to indicate environmental damage caused by human activity. Pollution especially chemicals are found to contaminate aquatic ecosystems and their animals including fish and amphibians during their adult life and sensitive stages of development. Nonylphenol ethoxylate (NPE) is one of the most dangerous chemicals that are recorded in aquatic environments, bacterial degradation of nonylphenol ethoxylates produces more toxic nonylphenol (NP) which is estrogenic both on vitro and vivo assays. In present work, the exposure of embryos of Egyptian toad Bufo regularis to different sublethal doses of 4-nonylphenol (1.5, 2.5, and 3.5 µgl-1) resulted in mortality rate increase and as a result some morphological malformations with histopathological changes in some organs were revealed. This study indicated the destructive effects of 4-Nonylphenol on the tadpoles of Egyptian toad.
Keywords: 4-Nonylphenol; malformations; histopathology, tadpoles; Bufo regularis
- Alaa El-Din H Sayed on Google Scholar
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- Sara S Abdel Hakeem on Google Scholar
- Sara S Abdel Hakeem on Pubmed
- Usama M Mahmoud on Google Scholar
- Usama M Mahmoud on Pubmed
- Imam A Mekkawy on Google Scholar
- Imam A Mekkawy on Pubmed