Global Advanced Research Journal of Microbiology (GARJM) ISSN: 2315-5116
November 2017 Vol. 6(7): pp. 051-061
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper

 

Prevalence, Risk and High Human Papilloma Virus IgM and IgG Concentration in Human Immune Deficiency positive individuals in Southwest Nigeria

Lawrence Ehis Okoror, and Samuel Ayodeji Osanyinlusi

 

Department of Microbiology, Federal University, Oye-Ekiti PMB 373, Oye-Ekiti, Nigeria

Email: loekoror@gmail.com

Accepted 17 October, 2017

 

Abstract

Background Human papillomavirus (HPV) are a major public health concerns among immune-compromised individuals. There is paucity of reports in Nigeria as to their prevalence and risk among HIV positive individuals and the antibody concentration to determine the level of infection. Methods and Findings. This study examined 797 individuals confirmed to be living with HIV using the competitive ELISA technique were screened for HPV and the concentration of IgG and IgM determined using ELISA among which 282 (37%) males were positive to HPV and 470 (63%) females. There was a high prevalence of HPV infection with overall of 76% and 0.6183 for the minimum and were 0.8004 for the maximum (CL=2.5%-97.5%) using the Bayesian estimate of true prevalence. The risk factors evaluated included alcohol intake, smoking, habit, comorbidity, sexual habit, HAART administration, other STIs, men having sex with men (MSM) and ages. The young and mid ages has the highest prevalence of HPV infection as well as have highest number of individuals with high concentration of IgM and IgG.  Conclusions. The high level of IgM is an indication of recent infection and the subjects may still be actively sexually involved. High smoking index, alcohol consumption, multiple  sexual  partners  and infection with more than 1 STI, hepatitis B virus (HBV) infection were implicated as risk or predisposing factors to HPV infection in HIV patients.  The high prevalence of HPV and identified risk factors among immunocompromised individuals has serious implications for healthcare. 

Keywords:  IgG, IgM, Concentration, HPV, HIV.

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