Global Advanced Research Journal of Microbiology (GARJM) ISSN: 2315-5116
December, 2014 Special Anniversary Review Issue. Vol. 3(9), pp 152-159
Copyright © 2014 Global Advanced Research Journals
Biochemical and virological aspects beyond Ebola virus - Prospects for medications and immunization
Mohammed Helmy Faris Shalayel*1, Ahmed Morad Asaad2, Jobran Miree Alqahtani3, Ietimad AM Ayed4, Mohamed Ansar Qureshi5, Moawia A Elbadri5
1Professor of Biochemistry, College of Medicine, Najran University, KSA.
2Professor of Microbiology, College of Medicine, Najran University, KSA.
3Vice-Rector for Academic Affairs and Dean of College of Medicine, Najran University, KSA.
4Pharmacology Department, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Sudan.
5Department of Microbiology, College of Medicine, Najran University, KSA.
*Corresponding Author’s Email: email@example.com
Accepted 01 December, 2014
Ebola virus disease (EVD) has a high fatality rate; currently lacks a treatment or vaccine with proven safety. In response, the World Health Organization has declared the Ebola outbreak in West Africa to be a Public Health Emergency of International Concern. However, Ebola is only transmitted by patients who already present symptoms of the disease, and infection only occurs upon direct contact with the blood or body fluids of an Ebola patient. Consequently, transmission of the outbreak can be contained through careful monitoring for fever among persons who have visited, or come into contact with persons from, the site of the outbreak. Thus, patients suspected of presenting symptoms characteristic of Ebola should be quarantined. Despite ongoing efforts directed at experimental treatments and vaccine development, current medical management of EVD is largely limited to supportive therapy, thus making early case identification and immediate implementation of appropriate control measures critical. Optimization of EVD management together with rapid diagnosis, greatly improve the clinical outcome. Recent advances in diagnostic procedures and new therapies of patients with several drugs in the initial phase of treatment could further improve the prognosis of EVD cases. This review summarizes the biochemical and virological characters of Ebola virus and highlights the challenges for development of new effective antiviral drugs and vaccine for prompt control and prevention of EVD outbreaks.
Keywords: Ebola virus disease (EVD), Filoviridae, Marburg virus disease, Outbreaks, ZMapp.
- Mohammed Helmy Faris Shalayel on Google Scholar
- Mohammed Helmy Faris Shalayel on Pubmed
- Ahmed Morad Asaad on Google Scholar
- Ahmed Morad Asaad on Pubmed
- Jobran Miree Alqahtani on Google Scholar
- Jobran Miree Alqahtani on Pubmed
- Ietimad AM Ayed on Google Scholar
- Ietimad AM Ayed on Pubmed
- Mohamed Ansar Qureshi on Google Scholar
- Mohamed Ansar Qureshi on Pubmed
- Moawia A Elbadri on Google Scholar
- Moawia A Elbadri on Pubmed