Global Advanced Research Journal of Microbiology (GARJM) ISSN: 2315-5116

March 2014 Vol. 3(2), pp 012-017

Copyright © 2014 Global Advanced Research Journals


Full Length Research Paper

Evaluation of haemoglobin concentration, packed cell volume and red cell indices in pre- and post-anti-malaria drug treatment in plasmodium falciparum malaria infected and control individuals

Ifeanyichukwu M.O1, Esan, A.J2.


Immunology Department, Nnamidi Azikiwe University, Nnewi Campus, Anambra State, Nigeria1

Haematology Department, Federal Medical Center, Ido-Ekiti, Ekiti State Nigeria2,

*Corresponding Author’s Email:

Accepted 03 March, 2014




This study was to evaluate haemoglobin concentration, packed cell voluFme and red cell indices in pre- and post anti-malaria drug treatment in Plasmodium falciparum malaria infected and control individuals. The study was conducted at Federal Medical Center, Ido-Ekiti, Ekiti State Nigeria; between November 2012 and March 2013; malaria infected adult individuals; presented with signs and symptoms of malaria infection was used for the study. 202 blood samples were collected twice from the same malaria infected individuals; grouped as pre-treatment and post anti-malaria drug treatment. 102 blood samples from apparently healthy individuals were collected for control; both malaria infected subjects and controls were within the age 15-64 years of both sex. 4ml of blood sample was collected and dispensed into di-potassium ethylenediaminetetracetic acid (K2EDTA) vaccutainer bottles for haemoglobin concentration, packed cell volume and red cell indices were analysed using haematology analyser (sysmex automated haematology analyser model kx-21n, maunfactured by sysmex co-operation kobe, Japan), thick blood film was made and stained with Giemsa’s staining technique for malaria parasite screening, the procedure was described by Monica Cheesbrough, 2005 . Data obtained was analysed using SPSS version 16. The result of this present study showed that, the mean ± SD of red blood cell, haemoglobin concentration, packed cell volume, red cell indices (MCV, MCH and MCHC) and red cell distribution width in post treatment were significantly (P<0.05) lower compared to pre treatment and control. The study showed that, anaemia is the common haematological changes in malaria P. falciparuminfection, the wide use of more effective anti-malaria would probably result in greater clinical and haematological benefits. However, the prevalence of malaria infection in male was higher compared to female.  

Keywords: malaria parasite, anaemia and anti-malaria drug.



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