Global Advanced Research Journal of Microbiology (GARJM) ISSN: 2315-5116

April, 2016. Vol. 5(3), pp 023-032

Copyright © 2016 Global Advanced Research Journals

 

Full Length Research Paper

Antimicrobial Activity of Microalgal Extracts Isolated From Baharia Oasis, Egypt

Entesar A. Ahmed

 

Botany and Microbiology Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo, Egypt.

*Corresponding Author’s Email: entesar18@yahoo.com

Accepted 30 April, 2016

 

Abstract

In the present study, the methanolic extract of  five species (four cyanobacterial and one green alga) namely Nostoc caeruleum, Spirulina platensis, Cylindrospermum majus, Oscillatoria formosa and Chlorella vulgaris were  tested with the agar well diffusion method for their antibacterial against three Gram positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes ) and three Gram negative bacteria (Klebsiella  pneumoniae, Pseudomonas aeruginosa and Escherichia coli) as well as for their antifungal activity against (Aspergillus fumigatus, Candida albicans, Geotricum candidumn and Trichophyton mentagrophytes). The results indicated that the extract of Chlorella vulgaris was more efficient against the tested bacteria and fungi strains followed by Spirulina  platensis. Chemical analyses showed that Chlorella vulgaris recorded the highest percentages of the total phenolic and total flavonoid contents. So, C. vulgaris crude extract was tested for their effectiveness as antioxidant activity. Also, Chlorella vulgaris extract screened for their anticancer activities against selected cancer cell lines; breast cancer cell lines MCF-7, colon cancer HCT-116 and liver cancer cell lines HepG-2. The results indicates that the HepG-2 was most sensitive followed by the HCT-116 than MCF-7 at (IC50) with 40.5, 43 and75.3. μg/ml respectively. Finally the result of GC mass analysis proved the presence of quercitin compounds.

Keywords: Soil microalgae, antimicrobial activity, Chlorella vulgaris, Baharia Oasis, Egypt.

 


 

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