Global Advanced Research Journal of Microbiology (GARJM) ISSN: 2315-5116

October 2014 Vol. 3(8), pp 133-143

Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Synthesis, spectroscopic, Thermal kinetic and computational studies on Charge-Transfer Complexes: (Panto & Ome)-prazole drug as donor and DDQ, CHLC & Iodine as acceptor

Doa'a Fawzi Ba'amer1, Elsayed El-Mossalamy2, Laila Mohammad Al-Harbi1*, Abdullah Yousif Obaid1

 

1Department of Chemistry, Faculty of Science, King  Abdulaziz University, P.O. Box 42805 Jeddah 21551 Saudi Arabia.

2Department of Chemistry, Faculty of Science, Benha University, Benha, Egypt.

*Corresponding Author's Email: sbdmina@yahoo.com;

Tel: +20-1009143680.

Accepted 10 October, 2014

 

Abstract

 

Charge transfer (CT) complexes were carried out using the most widely selling and effective pharmaceutical drugs as Pantoprazole (PANT) and Omeprazole (OMER) as electron donors; solid interaction with different benzoquinone derivatives as acceptors and  Iodine were isolated and characterized by IR and 1H-NMR (Nuclear magnetic resonance) .Thermo gravimetric analysis with different heating rates (TGA) were studied  on solid state complexes using computational integral methods for Coats Redfern and Ozawa using various solid state kinetic reaction models and established activation energy, energy band gape and thermodynamic parameters . The Differential Scanning Calorimetric (DSC) technique was used to study the nature decomposition of charge transfer complexes. The morphological structure were discussed and examined via Scanning Electron Microscopy (SEM).The molecular structures of Pentaprazole, DDQ, CHLC and I2& charge transfer complexes  in the ground state were made by using Gaussian 03  program package.

Keyword: thermal kinetic studies, pharmaceutical drugs, benzoquinone derivatives, Computational chemistry.

 

 

 

 


 

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