Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
January 2014 Vol. 3(1), pp. 001-007
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Efficacy and safety of artemisinin – naphthoquine (ARCO®) in the treatment of uncomplicated Plasmodium falciparum among Sudanese adults

Bakri Y.M. Nour1,2*, Naser Mahmoud M. Hamed2, Ali Babekir Habour3, Abd Alla Abd Elkariem1,3, Ahmed A. Mohamadani2,3 and Osman K Saeed1,4

1Blue Nile National Institute for Communicable Diseases, University of Gezira, Wad Medani, Sudan
2Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
3Faculty of Medicine, University of Gezira, Wad Medani, Sudan
4Wad Medani College for Medical Sciences and Technology, Wad Medani, Sudan

*Corresponding Author E-mail: saeedosman82@yahoo.com    

Accepted 17 December, 2013

Abstract

Although artemisinin combined therapies (ACTs) offer great hope for Africa in controlling malaria, the ideal combination regimen remains uncertain. ARCO is a single dose treatment and proven to be efficacious, so this study aimed to assess the safety and efficacy of this new generation ACT in the treatment of uncomplicated Plasmodium falciparum among Sudanese adults. From November 2006 to March 2008, the efficacy and safety of Artemisinin + Naphthoquine (ARCO) in the treatment of uncomplicated Plasmodium falciparum was investigated in Eastern and Central of Sudan. 129 patients were enrolled in this study, and were treated with ARCO. All patients were followed up for 28 days according to the WHO-in vivo protocol-2003. The results obtained by ARCO study revealed that the fever clearance time (FCT) was (12.0 +/- 4.8 hours) and parasite clearance time (PCT) was (34.8+/-12.6 hours), Overall clinical and parasitological outcome showed that adequate clinical and parasitological response (ACPR) was 120/122 (98.4%), early treatment failure (ETF) was 0/122 (0%) and late clinical and parasitological failure (LCPF) was 2/122 (1.6) and no Gametogenesis was observed during the follow-up days. ARCO proved to be an effective ACT, was very safe and well tolerated, no adverse reaction detected -There was no new events and no adverse effects on bone marrow

Keywords: Sudan, malaria treatment, ACT, ARCO.

Related Articles


Case Report
Bedawi Said Bedawi, Eltayeb Tayrab and Latief A Ashmaig
Olignecropermia infertility associated with Reifenstein syndrome in a Sudanese patient
Glo. Adv. Res. J. Med. Med. Sci. August 2014 Vol: 3(8): - [Abstract] [Full Text - PDF] (1,401 KB)
Original Research Articles
Ahmed Ibrahim Hashim, Amal Mubarak Hassan Mubarak, Nosiba Ahmed Hassan Hamed, and Ahmed Bakheet Abd Alla
Isolation of Aerobic Bacteria from Wounds of Diabetic Patients Undergoing Hyperbaric Oxygen Therapy in Khartoum State
Glo. Adv. Res. J. Med. Med. Sci. June 2018 Vol: 7(4): - [Abstract] [Full Text - PDF] (188 KB)
Gamal KM Ali and Abdeen M Omer
The Impact of the pharmaceutical regulations on the quality of medicines on the Sudanese market: Importers’ perspective
Glo. Adv. Res. J. Med. Med. Sci. August 2012 Vol: 1(7): - [Abstract] [Full Text - PDF] (203 KB)
Iman K.A. Abdel Gadir, Marmar A. El Siddig, Hayfa H.A. Ibrahim and Adil A. El Hussein
Factors Affecting Agrobacterium-mediated Transformation and Callus Induction of Sudan’s Cotton Genotypes
Glo. Adv. Res. J. Med. Med. Sci. April 2017 Vol: 6(4): - [Abstract] [Full Text - PDF] (1,727 KB)
Elsamawal Khalil Makki and Samia Abu-Elgasim Manzool
Relationship between management and field performance of draught animals used for land preparation. An example from South Kordofan State, Sudan
Glo. Adv. Res. J. Med. Med. Sci. March 2013 Vol: 2(3): - [Abstract] [Full Text - PDF] (244 KB)
Tag Alsir Altayeb Beshier Ahmed, Caroline Edward Ayad, Hussein Ahmed Hassan and Elsafi Ahmed Abdalla
Morphometric analyses of Substantia Nigra Pars Compacta, temporal lobes and lateral ventricles in Schizophrenia Disease: MRI Study
Glo. Adv. Res. J. Med. Med. Sci. December 2015 Vol: 4(12): - [Abstract] [Full Text - PDF] (164 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Bakri YM Nour on Google Scholar
Bakri YM Nour on Pubmed
Naser Mahmoud M Hamed on Google Scholar
Naser Mahmoud M Hamed on Pubmed
Ali Babekir Habour on Google Scholar
Ali Babekir Habour on Pubmed
Abd Alla Abd Elkariem1 on Google Scholar
Abd Alla Abd Elkariem1 on Pubmed
Ahmed A Mohamadani on Google Scholar
Ahmed A Mohamadani on Pubmed
Osman K Saeed1 on Google Scholar
Osman K Saeed1 on Pubmed

Statistics

Viewed 1634
Printed 388
Downloaded 1280
Powered By iPortal Works