Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
January 2016 Issue Vol. 5(1), pp. 029-034
Copyright © 2016 Global Advanced Research Journals


Full Length Research Paper

The concentration of cGMP in serum and clinical activity of multiple sclerosis

Natalia Lubina-Dąbrowska1*, Anna Magnuszewska2, Adam Stępień1 and Małgorzata Chalimoniuk2,3

1Department of Neurology, Military Institute of Medicine, Warsaw, Poland.
2Cardinal Stefan Wyszyński University, Warsaw, Poland.
3Mossakowski Medical Research Centre Polish Academy of Sciences

*Corresponding Author E-mail:,

Accepted 21 January, 2016


Multiple sclerosis (MS) is a demyelinating disease of the central nervous system of unknown etiology. The processes of demyelination accompanied by a local inflammatory process, which is the result of an autoimmune response to myelin antigens. The aim of this study was to analyze the levels of nitric oxide and cGMP in the serum of patients with multiple sclerosis (MS) during the relapse and remission. The study involved 27persons, including 11 patients (K7 / M4) during the MS relapse and 11 (K7 / M4) patients with MS in remission, and 7 normal subjects (5K / 2M). The concentration of cGMP and immunochemical method (ELISA) and the concentration of nitrite by Griess. The results showed higher levels of cGMP and nitrite in the serum of MS patients at relapse when compared to a control group and a group of MS patients in remission. Significant deterioration of neurological condition is a plan view of the disease evaluated by using the EDSS in patients with MS. The higher concentration of NO and cGMP levels in plan correlated with worse neurological status of patients with MS. The results suggest that nitric oxide and cGMP mediated MS causing neurologic deterioration of MS patients but not the main factors responsible for the changes taking place in the brain of MS.

Keywords: multiple sclerosis, cGMP, nitrogen oxide, EDSS

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