Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2013 Vol. 2(10), pp. 209-210
Copyright © 2013 Global Advanced Research Journals



Predictive biomarkers of response are required for the evaluation of patients with metastatic castration-resistant prostate cancer treated with a sequential regimen

Giandomenico Roviello

Medical Oncology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci 11, 53100 Siena, Italy.

E-mail:; Fax: +390577586139 

Accepted 09 October, 2013


Schrader et al analyzed the effects of the sequential regimen, Abiraterone Acetate (AA) followed by Enzalutamide (E). Their data showed that E is only moderately effective after AA failure. However, a significant biochemical response (>50% PSA decline) to E was observed only in some patients who had previously achieved a >50% PSA decline with AA treatment. Then, cross-resistance between AA and E seems to be a common event and in some cases OS achieved in patients after Docetaxel failure is even longer when they are treated with AA or E only rather than when a sequential strategy with these two agents is undertaken. However, a subset of these patients who underwent a sequential therapy has shown benefits in terms of OS. Therefore, the development of predictive biomarkers of response is required in order to tailor the new therapeutic agents to the biology of the cancer and to obtain max OS.

Keywords: Abiraterone Acetate, Enzalutamide, Sequential regimen, Cross-resistance


Related Articles

Original Research Articles
Nurul Hazrina Mazlan and Affizal Ahmad
Psychological profile of Malaysian female prisoners
Glo. Adv. Res. J. Med. Med. Sci. July 2012 Vol: 1(6): - [Abstract] [Full Text - PDF] (149 KB)
Hanan MM Tork and Fathia Ahmed Mersal
Middle East Respiratory Syndrome-Corona virus: Knowledge and attitude of Qassim University students, KSA
Glo. Adv. Res. J. Med. Med. Sci. April 2018 Vol: 7(4): - [Abstract] [Full Text - PDF] (1,930 KB)
Camilus Bassey Ben
The Role of Rural Women Farmers in Household Food Security in Cross River State, Nigeria
Glo. Adv. Res. J. Med. Med. Sci. March 2015 Vol: 4(3): - [Abstract] [Full Text - PDF] (148 KB)
Mohammed Ratoubi Alanazi, Ahmed Alamry, Mohammed Hussein and Mansour Moklif Alanzi
Canonical correlation between safety culture and quality of healthcare in Saudi Arabia
Glo. Adv. Res. J. Med. Med. Sci. September 2015 Vol: 4(9): - [Abstract] [Full Text - PDF] (113 KB)
Ndem Ayara Ndiyo and Josephat Odo Ogar
Upscaling of sub national transportation and communication infrastructure in Nigeria A case study of Cross River State
Glo. Adv. Res. J. Med. Med. Sci. November 2012 Vol: 1(10): - [Abstract] [Full Text - PDF] (425 KB)
Hind A. A. Al-Zahrani
Solid state fermentation using agro industrial residues for alpha amylase production by an actinomycete isolate from red sea soil
Glo. Adv. Res. J. Med. Med. Sci. June 2018 Vol: 7(4): - [Abstract] [Full Text - PDF] (458 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Gi on Google Scholar
Gi on Pubmed
omenico Roviello on Google Scholar
omenico Roviello on Pubmed


Viewed 1412
Printed 688
Downloaded 656
Powered By iPortal Works