Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2014 Vol. 3(10), pp. 315-321
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Expression of glucose transporters in placenta from macrosomic infants

Sandra Alicia Reza-López Ph.D1, Blanca Estela Sánchez-Ramírez Ph.D2, Daniela Sarahí Gutiérrez-Torres M.Sc2,  Mariela Rodríguez-Salinas1, Martha Grisell Ortega-Valerio1, Dora Virginia Chávez-Corral M.D1 and Margarita Levario-Carrillo, Ph.D1*

1Facultad de Medicina, Universidad Autónoma de Chihuahua. Circuito Universitario, Campus II, C.P. 31109, Chihuahua, Chih., México.
2Programa de Maestría en Ciencias en Biotecnología, Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua. Circuito Universitario, Campus II, C.P. 31109, Chihuahua, Chih., México

*Corresponding Author Email: mlevarioc@uach.mx; Phone: +52 (614) 439-1500 Ext. 3572;  Fax +52 (614) 238-6036

Accepted 17 October, 2014

Abstract

Maternal glucose status and placental transport are related to macrosomia in pregnancies complicated with diabetes mellitus. However, there is little information on the placental expression of glucose transporters in non-complicated pregnancies. The objective of this study was to compare the expression glucose transporters GLUT1 and GLUT3 in placenta from macrosomic and normal weight newborns. Information on maternal factors was obtained from clinical records. Protein expression  of GLUT1 and GLUT3 glucose transporters was determined by immunohistochemistry in archived term placenta samples of singleton, non-diabetic pregnancies, from macrosomic (>4000g) and normal weight newborns, matched for gestational age (±1week) and gender (n=25 pairs) for a case-control study. Macrosomia was more frequent in newborns from women with pregestational overweight (body mass index ≥25 kg/m2, p=0.046) or with glucose concentration ≥85 mg/dL (p=0.01).  Placentas in the highest tertile of GLUT3 expression had 5 times the chance of being from macrosomic newborns compared to controls (p<0.05). This association remained significant after adjusting for other maternal factors. Protein expression of GLUT1 was not different between groups. Term placentas from macrosomic newborns from uncomplicated pregnancies show increased protein expression of GLUT3 but not GLUT1.

Keywords: Macrosomic, placenta, glucose, GLUT, birth weight

 

Related Articles


Original Research Articles
Hind A. A. Al-Zahrani
Genetic mutagenesis through Transposable element 5 (Tn5) to improve beta-D-galactosidase productivity from different bacterial strains
Glo. Adv. Res. J. Med. Med. Sci. May 2018 Vol: 7(3): - [Abstract] [Full Text - PDF] (1,393 KB)
Ghada Al-Ghazaly and Tarek El-Sharawy
Study of Increased Atherosclerosis Risk In Hepatitis C virus and Cytomegalovirus Seropositive Haemodialysis Patients
Glo. Adv. Res. J. Med. Med. Sci. October 2015 Vol: 4(10): - [Abstract] [Full Text - PDF] (113 KB)
Eleyan, Sohair E.D, Abodahab, Abdall A, Abdallah, Amany M, Hossain, MF and Rabeh, Houda A.
Effect of nitrogen, phosphorus and potassiumnano-fertilizers in different application times, methods and rates on: II. Yield, yield components and fiber properties of Egyptian cotton (Gossypiumbarbadense L.)
Glo. Adv. Res. J. Med. Med. Sci. July 2018 Vol: 7(7): - [Abstract] [Full Text - PDF] (0 KB)
Ragaa Hosny Mohamad1, Azza Mahmoud Farahat, Mohamad Gamil Abdel Moneim, Amal Mohamad El Bastawesy, Safaa Ahmed Salem
Therapeutic Value Of Camel Milk Supplemented With Echinacea Consumption By Albino Rat
Glo. Adv. Res. J. Med. Med. Sci. March 2015 Vol: 4(3): - [Abstract] [Full Text - PDF] (1,317 KB)
Johnny II, Ekong NJ and Okon JE
Phytochemical Screening and Anti-hyperglycaemic Activity of Ethanolic Extract of Terminalia ivorensis A. Chev. Leaves on Albino Wistar Rats
Glo. Adv. Res. J. Med. Med. Sci. August 2014 Vol: 3(8): - [Abstract] [Full Text - PDF] (103 KB)
Azza A El-Masry
Potential Therapeutic Effect of Curcuma longa on Streptozotocin Induced Diabetic rats
Glo. Adv. Res. J. Med. Med. Sci. May 2012 Vol: 1(4): - [Abstract] [Full Text - PDF] (155 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

S on Google Scholar
S on Pubmed
ra Alicia Reza-Lopez on Google Scholar
ra Alicia Reza-Lopez on Pubmed
Blanca Estela Sánchez-Ramírez on Google Scholar
Blanca Estela Sánchez-Ramírez on Pubmed
Daniela Sarahí Gutiérrez-Torres on Google Scholar
Daniela Sarahí Gutiérrez-Torres on Pubmed
Mariela Rodríguez-Salinas on Google Scholar
Mariela Rodríguez-Salinas on Pubmed
Martha Grisell Ortega-Valerio on Google Scholar
Martha Grisell Ortega-Valerio on Pubmed
Dora Virginia Chávez-Corral on Google Scholar
Dora Virginia Chávez-Corral on Pubmed
Margarita Levario-Carrillo on Google Scholar
Margarita Levario-Carrillo on Pubmed

Statistics

Viewed 2386
Printed 1925
Downloaded 1708
Powered By iPortal Works