Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2015 Vol. 4(10), pp. 426-434
Copyright © 2015 Global Advanced Research Journals

 

Full Length Research Paper

Oxidative stress and power in patients post - kidney transplantation: a cross study

Valéria Baccarin Ianiski, Ligia Beatriz Bento Franz, Juliana Schneider, Matias Nunes Frizzo*, Eliane Roseli Winkelmann

Regional University of the Northwest of the State of Rio Grande do Sul

*Corresponding Author E-mail: matias.frizzo@gmail.com

Accepted 02 October 2015

Abstract

The kidneys perform vital functions of our body and they endocrine function, metabolism and excretion. With the development of chronic kidney disease, these functions are compromised requiring that substitutive treatments are incorporated. Kidney transplantation is presented as the potential cure for end-stage Chronic Kidney Disease, providing lower morbidity and improved quality of life for individuals. This study evaluated the dietary intake and nutritional status of the patient post - transplanted kidney and its relationship with oxidative stress and oxidative defense. This was a cross-sectional study, quantitative, analytical with 12 patients of both genders, age 25 to 80 who had undergone renal transplantation more than one year. Data were processed with the help of the SPSS statistical package (versão18.0, Chicago, IL, USA). The descriptive analysis this presented as mean, standard deviation, relative and absolute frequency. For quantitative variables was performed the Kolmogorov-Smirnov normality test, and for parametric we used the t test (Student) and for non-parametric U test (Mann Whitney) to compare the averages. In the qualitative variables, we used the chi-square test and Fisher's exact Pearson. To correlate parametric variables we used the Pearson test and nonparametric Spearman test. we obtained 11 (91,7) individuals of the sample with high blood pressure and nutritional status of overweight 27,70±5,19 kg/m2 and high waist circumference 98,37±14,75 cm. The consumption of NSAIDs for females was significant (p = 0,022). The consumption of foods such as banana, bergamot, papaya, tomato, salsa, milk and coffee prevailed in the questionnaire with food intake of one or more times a day. Malondialdehyde levels were associated with significant when antioxidant enzymes and not as significant portions of the vitamins (A, C, D, E). The non-verification of GPx levels were characterized as a limiter of this study. it is noticeable that the power directly influences the antioxidant defense system of the body in tandem with the antioxidant enzymes CAT, SOD and GPx. Significant levels of malondialdehyde have stronger relationship with the antioxidant enzymes than with food; however, there are dietary factors - nutrients - that serve as cofactors in the process of antioxidant defense. Thus, the post patient's food - renal transplant must meet the principles of healthy eating, with minimal processed foods with a view to fresh food, in order to limit the impacts of everyday life, their grievances and drugs on health, thereby minimizing the metabolic stress.

Keywords: antioxidants, oxidative stress, chronic renal failure, kidney transplantation, biomarkers.

List of Abbreviations

AINE, Non steroid anti-inflammatory; BIA, Electrical bioimpedance; CA, Abdominal circumference; CAT, Catalase; DCV, Cardiovascular disease; DM, Diabetes Mellitus; DRC, Chronic Kidney Disease; EO, Oxidative Stress; GPx- Glutathione peroxidase; HAS, Systemic Hypertension; IMC, Body Mass Index; Kg, Kilograms; MDA, Malondialdehyde; NO, Nitric oxide; QFCA, Food Consumption Frequency Questionnaire; SOD, Superoxide Dismutase; TBARS, Thiobarbituric Acid; TX, Transplantation


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