Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2015 Vol. 4(10), pp. 435-440
Copyright © 2015 Global Advanced Research Journals

 

Full Length Research Paper

Study of Increased Atherosclerosis Risk In Hepatitis C virus and Cytomegalovirus Seropositive Haemodialysis Patients

Ghada Al-Ghazaly1* and Tarek El-Sharawy2

1Lecturer, Internal Medicine Department, Faculty of medicine, Tanta University, Egypt.
2Assistant Professor, Internal Medicine Department, Faculty of medicine, Tanta University, Egypt.

*Corresponding  Author  E-mail: dodoya288@yahoo.com

Accepted 02 October 2015

Abstract

Hepatitis C virus (HCV) is the most common liver disease in renal dialysis patients. Also, cytomegalovirus (CMV) is a common infection in chronic hemodialysis patients (CHD).  HCV and CMV patients are more likely to have carotid atherosclerosis plaques as compared to negative individuals. The aim of this study is to assess the association between HCV and CMV seropositivity, dyslipidemia, carotid artery plaques and media intima thickening in hemodialysis patients. Sixty patients with chronic kidney disease (CKD) on regular hemodialysis were selected from hemodialysis unit in Tanta university hospital.  All subjects were subjected to medical history taking, physical examination, complete blood picture (CBC), fasting blood glucose (FBS), liver function tests, lipid profile, serum calcium, serum phosphorus, INR, prothrombin concentration , C-reactive protein (CRP), HCV Ab (ELISA) and CMV IgG and Duplex on both Carotid arteries with measurement of intimal medial thickness. The prevalence of atherosclerosis in HCV, CMV positive and negative patients undergoing hemodialysis is not influenced by many factors (p value >0.05): sex, age, and body mass index, systolic and diastolic blood pressure, Also there was no significant change in serum albumin, bilirubin, prothrombin concentration, INR, CBC, FBS, CRP, serum phosphorus and ionized calcium. There was significant increase in atherosclerosis among HCV and CMV positive compared to negative patients undergoing hemodialysis as proved by Carotid Duplex. Atherosclerosis is increased in HCV and CMV seropositive compared to seronegative patients under hemodialysis as proved by Carotid Duplex.

Keywords: Hepatitis C virus, cytomegalovirus, Haemodialysis, Atherosclerosis, Carotid Duplex, Risk factors

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