Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2017 Vol. 6(10), pp. 267-270
Copyright © 2017 Global Advanced Research Journals

 

Case Report 

Copper nanoparticles as treatment of diabetic foot ulcers: A case report

T. Lopez Goerne1,2*, A. Arévalo3, P. Ramírez1 and P. Larraza1.

1Laboratorio de Nanotecnología y Nanomedicina, Departamento de Atención a la Salud. Universidad Autónoma Metropolitana-Xochimilco. Calzada del Hueso 1100, Col. Villa Quietud, Delegación Coyoacán, C. P. 04960, Ciudad de México.
2Facultad de Medicina, Universidad Nacional Autónoma de México.
3Laboratorios de Nanomedicina y Nanotecnología. Nano Tutt S.A. de C.V.

*Corresponding Author E-mail: tessy3@prodigy.net.mx

Accepted 27 October, 2017

Abstract

Copper nanoparticles were prepared by the sol-gel process to obtain nanoparticles of 2.4 nm. The material was characterized by Transmission Electron Microscopy (TEM) and Fourier Transformed Infrared Spectroscopy (FTIR). This nanomaterial was used to treat a diabetic foot ulcer in a 58 years old male patient. The patient presented type 2 diabetes mellitus with13 years of evolution, with macro and micro vascular complications. The illness shown by retinopathy, state 2 chronic renal disease, peripheral artery disease, critical limb ischemia with the presence of an ulcer in the right heel and anipsilateral necrotic lesion in the 2nd, 3rd, and 4th toes. This patient was already programmed for a supracondylar amputation. In order to avoid the amputation, the patient was included into the clinic trial to be treated with copper nanoparticles. After a three-month treatment, the ulcer evolved with positive clinical results.

Keywords: Nanoparticles, copper, diabetic foot, ulcers, diabetes, case report

 

References

Akkurt MO, Demirkale I, Öznur A (2017). Partial calcanectomy and Ilizarov external fixation may reduce amputation need in severe diabetic calcaneal ulcers. Diabet Foot Ankle. 8(1):1264699. doi:10.1080/2000625X.2017.1264699.

Alavi A, Sibbald RG, Mayer D, et al (2014). Diabetic foot ulcers: Part II. Management. J. Am. Acad. Dermatol. 70(1):21.e1-21.e24. doi:10.1016/j.jaad.2013.07.048.

Amin N, Doupis J (2016). Diabetic foot disease: From the evaluation of the “foot at risk” to the novel diabetic ulcer treatment modalities. World J. Diabetes. 7(7):153. doi:10.4239/wjd.v7.i7.153.

Apelqvist J (2012). Diagnostics and treatment of the diabetic foot. Endocrine. 41(3):384-397. doi:10.1007/s12020-012-9619-x.

Castro G, Liceaga G, Arrioja A, et al (2009). Artículo de revisión Guía clínica basada en evidencia para el manejo del pie diabético. Artículo de revisión. 25(6):481-526.

Dahiru I, Amaefule K, Okpe I, Ibrahim A, Muazu S (2016). An overview of diabetic foot disease. Niger. J. Basic Clin. Sci. 13(1):1. doi:10.4103/0331-8540.176206.

Dastjerdi R, Montazer M (2010). A review on the application of inorganic nano-structured materials in the modification of textiles: Focus on anti-microbial properties. Colloids Surfaces B Biointerfaces. 79(1):5-18. doi:10.1016/j.colsurfb.2010.03.029.

Ética Q De (2015). Ortopedia y Traumatología. Rev. Colomb. Ortop. y Traumatol. doi:10.1016/j.rccot.2015.04.006.

Godoy-Santos AL, Amodio DT, Pires A, et al (2017). Diabetic limb salvage procedure with bone allograft and free flap transfer: a case report. Diabet Foot Ankle. 8(1):1270076. doi:10.1080/2000625X.2016.1270076.

Guadarrama FC (2011). Cuidado de los pies en usuarios que viven con diabetes en el estado de México: bases para la sistematización de la asistencia de enfermería. 2(1):23-27.

Günal Ö, Tuncel U, Turan A, Barut S, Kostakoglu N (2015). The Use of Vacuum-Assisted Closure and GranuFoam Silver ® Dressing in the Management of Diabetic Foot Ulcer. Surg Infect (Larchmt). 16(5):558-565. doi:10.1089/sur.2014.093.

Hajimiri M, Shahverdi S, Esfandiari MA, et al (2016). Preparation of hydrogel embedded polymer-growth factor conjugated nanoparticles as a diabetic wound dressing. Drug Dev. Ind. Pharm. 42(5):707-719. doi:10.3109/03639045.2015.1075030.

Haycocks S, Chadwick P, Guttormsen K (2011). Use of a DACC-coated antimicrobial dressing in people with diabetes and a history of foot ulceration. Wounds UK. 7(1):108-114.

Kanchanasamut W, Pensri P (2017). Effects of weight-bearing exercise on a mini-trampoline on foot mobility, plantar pressure and sensation of diabetic neuropathic feet; a preliminary study. Diabet. Foot Ankle. 8(1):1287239. doi:10.1080/2000625X.2017.1287239.

Kim BYS, Rutka JT, Chan WCW (2010). Nanomedicine. N. Engl. J. Med. 363(25):2434-2443. doi:10.1056/NEJMra0912273.

Limb DL, Surgery P, Vidyapeetham AV, Limb DL, Surgery P (2013). Revascularization in the diabetic lower limb « J. Diabet. Foot Complications.  5 (1)18-23. http://jdfc.org/2013/volume-5-issue-1/revascularization-in-the-diabetic-lower-limb/.

López T, Rodríguez CE (2015). Uso de la nanopartícula de de úlceras en pie diabético: comunicación preliminar. Rev. la Fac Med la UNAM. 58:5-12.

Moura LIF, Dias AMA, Carvalho E, De Sousa HC (2013). Recent advances on the development of wound dressings for diabetic foot ulcer treatment - A review. Acta Biomater. 9(7):7093-7114. doi:10.1016/j.actbio.2013.03.033.

Nacionales R (2012). Encuesta Nacional de Salud y Nutrición.  CDMX.

O’Loughlin A, McIntosh C, Dinneen SF, O’Brien T (2010). Review Paper: Basic Concepts to Novel Therapies: A Review of the Diabetic Foot. Int. J. Low Extrem Wounds. 9(2):90-102. doi:10.1177/1534734610371600.

Pemayun TGD, Naibaho RM (2017). Clinical profile and outcome of diabetic foot ulcer, a view from tertiary care hospital in Semarang, Indonesia. Diabet Foot Ankle. 8(1):1312974. doi:10.1080/2000625X.2017.1312974.

Piao Y, Burns A, Kim J, Wiesner U, Hyeon T (2008). Designed fabrication of silica-based nanostructured particle systems for nanomedicine applications. Adv. Funct. Mater. 18(23):3745-3758. doi:10.1002/adfm.200800731.

Practice IB (2013). Best practice guidelines : Wound Management in Diabetic Foot Ulcers.

Rao S, Pallela N, Narahari P (2017). Comparison of negative pressure wound therapy with moist wound therapy in the treatment of diabetic foot ulcers with non- revascularisable peripheral vascular disease. 4(7):1-4.

Ruiz, Parizzi, Pezzotto P (2013). Estudio de casos y controles. Métodos Investig. clínica y epidemiológica. 81(2):131-137. doi:10.1016/B978-84-8174-709-6.50008-7.

Sandri G, Bonferoni MC, D’Autilia F, et al (2013). Wound dressings based on silver sulfadiazine solid lipid nanoparticles for tissue repairing. Eur. J. Pharm. Biopharm. 84(1):84-90. doi:10.1016/j.ejpb.2012.11.022.

Smith BR, Gambhir SS (2017). Nanomaterials for in Vivo Imaging. Chem. Rev. 117(3):901-986. doi:10.1021/acs.chemrev.6b00073.

Surgeons AA of O (2012). Pie diabético. 56:47-52. http://orthoinfo.aaos.org/topic.cfm?topic=A00683.

Tarride JE, Hopkins R, Blackhouse G, et al (2010). A Review of Methods Used in Long-Term Cost-Effectiveness Models of Diabetes Mellitus Treatment. Pharmacoeconomics. 28(4):255-277. doi:10.2165/11531590-000000000-00000.

Vásquez-garcía R (2015). Perfiles clínico y epidemiológico de los pacientes con pie diabético Clinical and epidemiological profiles of patients with diabetic foot. pp. 294-301.

Volmer-Thole M, Lobmann R (2016). Neuropathy and diabetic foot syndrome. Int. J. Mol. Sci. 17(6). doi:10.3390/ijms17060917.

 

Related Articles


Case Report
Awe JAA
Self knotting of Nasogastric tube: an unusual and rare complication.
Glo. Adv. Res. J. Med. Med. Sci. May 2014 Vol: 3(4): - [Abstract] [Full Text - PDF] (145 KB)
Original Research Articles
Elsayed AM Shokr, Alhazemi A, Naser T, Talal A Zuhair, Adel A Zuhair, Ahmed N Alshamary, Thamer A Alanazi and Hosam A Alanazi
Chronic Renal Failure Associated with Heavy Metal Contamination of Drinking Water in Hail, KSA
Glo. Adv. Res. J. Med. Med. Sci. January 2016 Vol: 5(1): - [Abstract] [Full Text - PDF] (124 KB)
I Buraga, G Mihailescu, RM Anton, M Buraga and C Baetu
Hepathopathy in children and young patients – Do you think of Wilson’s Disease (Hepatolenticular Degeneration)?
Glo. Adv. Res. J. Med. Med. Sci. September 2014 Vol: 3(9): - [Abstract] [Full Text - PDF] (98 KB)
Danilo C. Vasconcelos, Claubia Pereira, Arno H. Oliveira, Mário RS Silva, Fernando R. Carvalho, Thiago C. de Oliveira, Maria AC Borges, Maria IG Severo and Linda Ayouni-Derouiche
Study of metal and trace metals in shrimps Macrobrachium rosenbergii in creating captivity, aimed at domestic consumption and export.
Glo. Adv. Res. J. Med. Med. Sci. November 2014 Vol: 3(11): - [Abstract] [Full Text - PDF] (319 KB)
Case Reports
Caroline Edward Ayad, Monadhil Awad Fadl El Mola, Mohammed Abdelwahab Idriss Salih, Elsafi Ahmed Abdalla and Samih Awad Kajoak
Computed Tomography Based Agatston Scoring in the Diagnosis of Coronary Artery Disease: A Case Report
Glo. Adv. Res. J. Med. Med. Sci. June 2014 Vol: 3(6): - [Abstract] [Full Text - PDF] (487 KB)
Yassin Hamid, El Mouzan MI, Assiri MA, Alrikabi A, Alsarkhy A and Saeed Anjom
Asymptomatic Eosinophilic Esophagitis in apatient with very early-onset ulcerative colitis
Glo. Adv. Res. J. Med. Med. Sci. February 2015 Vol: 4(2): - [Abstract] [Full Text - PDF] (563 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Lopez Goerne T on Google Scholar
Lopez Goerne T on Pubmed
Arevalo A on Google Scholar
Arevalo A on Pubmed
Ramirez P on Google Scholar
Ramirez P on Pubmed
Larraza P on Google Scholar
Larraza P on Pubmed

Statistics

Viewed 805
Printed 124
Downloaded 355
Powered By iPortal Works