Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
October 2018, Vol. 7(8), pp. 165-168
Copyright © 2018 Global Advanced Research Journals
Full Length Research Article
Protection by Dialium indium (Fruit) against Pb2+-Induced Microcytic Anemia and Chromosome Aberration in Albino Rats In Vivo
Tugbobo O.S.*, Abegunde S.M. and Idowu K.S.
Department of Science Technology, Federal Polytechnic, Ado-Ekiti, Nigeria
*Corresponding Author E-mail: email@example.com
Accepted 24 October, 2018
The chelating ability and anticlastogenic potential of Dialium indium aqueous extract on lead-induced microcytic anemia and chromosome aberration was investigated in albino rats. Twenty rats were randomly grouped into four where rats in group B were treated daily with oral administration of 2.5mg/kg lead acetate, animals in C were fed simultaneously with 2.5mg/kg lead acetate and 200mg/kg Dialium indium extract while group D animals were fed 200mg/kg Dialium indium extract only and animals in group A served as control. The animals were sacrificed after four weeks of exposure and the toxicological effect of lead and the plant extract on hemoglobin-enzymes and chromosomes were equally assessed via micronucleus assay. The results from hematogical and micronucleus assay suggest that lead could possibly induce microcytic-anemia and as well initiate the development of chromosome aberration in albino rats as observed in group B animals, while the extract offered protective effect to animals in group C. However, the extract anticlastogenic and chelating potential was in synergy with the activity of hemoglobin-enzymes as the frequency of chromosome aberration was significantly (P<0.05) low in group D animals compared to those in group B.
Keywords: Microcytic anemia, Dialium indium, lead acetate, anticlastogenic, hemoglobin-enzymes.
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