Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
November 2015 Vol. 4(11), pp. 485-492
Copyright © 2015 Global Advanced Research Journals

 

Full Length Research Paper 

Diabetes Mellitus Causes Changes in the Heart Intrinsic Serotonergic System During the Development of the Cardiomyopathy

Gabriel Manjarrez-Gutiérrez1,2*, Teresa Neri-Gómez1, Rocio Herrera-Marquez1, Alfonso Boyzo-Montes de Oca3, Armando Mansilla-Olivares1, Jorge Hernández-Rodríguez3

1Laboratory of Molecular Pathology, Cardiology Hospital, National Medical Center (CMN-SXXI), Mexican Institute of Social Security (IMSS), Mexico City, Mexico
2Medical Research Unit in Neurological Diseases, Specialties Hospital, CMN-SXXI, IMSS, México, DF, México
3Laboratory of Neurontogeny, Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies (CINVESTAV) IPN, Mexico City, Mexico.

*Corresponding Author E-mail: willisga@prodigy.net.mx; gmanjarrezg@gmail.com; Phone: (+52) (55) 56276900, Ext. 22156. Fax: (+52) (55) 55780240

Accepted 27 November, 2015

Abstract

The main objective of the study was to explore some of the intrinsic serotonergic system changes suffered during the development of diabetic cardiomyopathy (DCM). The diabetes mellitus model by streptozotocin (STZ) was used with their respective controls. Hearts were obtained at 7, 14 and 21 days after STZ to evaluate: tryptophan-5-hydroxylase (TPH) activity and serotonin (5-HT) concentration measured by high-resolution liquid chromatography. Besides, it was determined the expression of 5-HT1B, 5-HT2A, and 5-HT2B receptors, as well as the serotonin transporter (SERT) expression by means of Western blot analyses. At day, 7, diabetic rats showed a remarkable decrease of activity and expression of the TPH1 and of the 5-HT concentration (P < 0.001), without any change on TPH2 expression. At day 14 it was also observed a decrease in the expression of SERT and 5-HT2B receptors (P < 0.001), and an increase in 5-HT2A receptors’ expression (P < 0.001). No changes were observed of 5-HT1B expression. These results suggest that the observed alterations may play an important role in the development of the DCM, which is frequently observed in diabetic patients.

Keywords: Diabetes, Cardiomyopathy, Heart, Serotonergic system.

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