Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
November 2018, Vol. 7(9), pp. 169-171
Copyright © 2018 Global Advanced Research Journals

 

Full Length Research Article

Growth hormone “GH “profile in Sanjad Sakati Syndrome

Nasir A Al-­Jurayyan1*, Hala G Omer2, Huda A Osman3, Reem A Alkhalifah4, Abdulmajeed A Alsubaihin4, Hessah M Al-Otaibi5 and Sharifah T. AlIssa5

1Professor And Consultant Pediatric Endocrinologist, Endocrine Division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia
2Fellow, Endocrine Division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia
3Senior registrar, Endocrine Division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia
4Assistant professor and consultant pediatric endocrinologist, endocrine division, department of pediatrics, King Saud University, Riyadh, Saudi Arabia.
5Consultant pediatric endocrinologist, endocrine division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia

*Corresponding Author E-mail: njurayyan@gmail.com; Telephone No: 00966505400592
 

Accepted 19 November, 2018

Abstract

Sanjad Sakati Syndrome (SSS) or congenital hypoparathyroidism growth retardation, and dysmorphism is rare autosomal recessive disease that typically present with intrauterine growth retardation (IUGR). Distinct dysmorphic feature early hypocalcaemia and developmental delay. This study was to assess growth hormone (GH) status in patients with Sanjad Sakati Syndrome. During the period March 2010 and July 2018, six Saudi children with clinical feature of SSS who were confirmed to have mutations in TBCE were investigated with physiological (sleep), and pharmacological (arginine, L dopa and clonoidine) growth hormone tests, at the endocrine services, King Khalid University Hospital (KKUH), Riyadh ,Saudi Arabia. Six patients with SSS were studied, four males and two females. Their ages ranged 6-­‐16 years (mean 9.2 yrs). Five out of six patients (83.3%) had normal growth results. Our results indicate that the majority (83.3.%) of patients were not growth hormone deficiency (GH), However neuroendocrine assessment, Insulin like growth factor (IGF.1) growth hormone (GH) axis and neuro_radiological Imaging studies should be carried out to delineate the nature of disorder.

Keywords: Growth hormone, Neuro endocrine radiological imaging, Sanjad _Sakati_syndrome

 

 

References

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Nasir A Al-Jurayyan on Google Scholar
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