Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
November 2018, Vol. 7(9), pp. 169-171
Copyright © 2018 Global Advanced Research Journals


Full Length Research Article

Growth hormone “GH “profile in Sanjad Sakati Syndrome

Nasir A Al-­Jurayyan1*, Hala G Omer2, Huda A Osman3, Reem A Alkhalifah4, Abdulmajeed A Alsubaihin4, Hessah M Al-Otaibi5 and Sharifah T. AlIssa5

1Professor And Consultant Pediatric Endocrinologist, Endocrine Division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia
2Fellow, Endocrine Division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia
3Senior registrar, Endocrine Division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia
4Assistant professor and consultant pediatric endocrinologist, endocrine division, department of pediatrics, King Saud University, Riyadh, Saudi Arabia.
5Consultant pediatric endocrinologist, endocrine division, Department of Pediatrics, King Saud University, Riyadh, Saudi Arabia

*Corresponding Author E-mail:; Telephone No: 00966505400592

Accepted 19 November, 2018


Sanjad Sakati Syndrome (SSS) or congenital hypoparathyroidism growth retardation, and dysmorphism is rare autosomal recessive disease that typically present with intrauterine growth retardation (IUGR). Distinct dysmorphic feature early hypocalcaemia and developmental delay. This study was to assess growth hormone (GH) status in patients with Sanjad Sakati Syndrome. During the period March 2010 and July 2018, six Saudi children with clinical feature of SSS who were confirmed to have mutations in TBCE were investigated with physiological (sleep), and pharmacological (arginine, L dopa and clonoidine) growth hormone tests, at the endocrine services, King Khalid University Hospital (KKUH), Riyadh ,Saudi Arabia. Six patients with SSS were studied, four males and two females. Their ages ranged 6-­‐16 years (mean 9.2 yrs). Five out of six patients (83.3%) had normal growth results. Our results indicate that the majority (83.3.%) of patients were not growth hormone deficiency (GH), However neuroendocrine assessment, Insulin like growth factor (IGF.1) growth hormone (GH) axis and neuro_radiological Imaging studies should be carried out to delineate the nature of disorder.

Keywords: Growth hormone, Neuro endocrine radiological imaging, Sanjad _Sakati_syndrome




Farquharson C, Lester D, Seawright E, Jefferies D, Houston B (1999)-­‐  Microtubules are potential regulators of growth-­‐plate chondrocyte differentiation and hypertrophy, Bone. 25(4):405-­‐412.

Gandrud LM , Wilson DM (2004).Is growth hormone stimulation testing in children still appropriate? ,Growth hormone and Igf Res. 14:185-­‐194.

Hershkovitz E, Rozin I,Limony Y,Golan H, Hadad N, Gorodischer R, Levy R(2007). Hypoparathyroidism, Retardation, and Dysmorphism Syndrome: Impaired Early Growth and Increased Susceptibility to Severe Infections Due to Hyposplenism and Impaired Polymorphonuclear Cell Functions, Pediatric Res. 62:505-­‐509.

Hunziker EB, Schenk RK (1989). Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats. J. physiol. 414: 55-­‐71.

Marsden D, Nyhan W L, Sakat  NA (1994).  Syndrome of hypoparathyroidism, growth hormone deficiency, and multiple minor anomalies. 52: 334-­‐338.

Padidela R, Kelberman D, Press M, et al (2009). Mutation in the TBCE gene is associated with hypoparathyroidism-­‐retardation-­‐dysmorphism syndrome featuring pituitary hormone deficiencies and hypoplasia of the anterior pituitary and the corpus callosum, J. Clin. Endocrinol. Metab. 94:2686-­‐2691.

Parvari R, Hershkovitz E, Grossman N, et al (2002). Mutation of TBCE causes hypoparathyroidism-­‐retardation-­‐dysmorphism and autosomal recessive Kenny-­‐Caffey syndrome. Nature Genet. 32:448–452.

Richardson RJ, Kirk JM (1990). Short stature, mental retardation syndrome, and hypoparathyroidism: a new syndrome Arch. Dis. Child. 65: 1113-­‐1117.

Sanjad SA, Sakati NA, Abu-­‐Osba YK, et al (1991).. A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. Arch. Dis. Child. 66:193– 196.

Smith WJ, Nam TJ, Underwood LE, Busby WH, Celnicker A, Clemmons DR (1993).  Use of insulin-­‐like growth factor-­‐binding protein-­‐2 (IGFBP-­‐2), IGFBP-­‐3, and IGF-­‐I for assessing growth hormone status in short children. J.  Clin.  Endocrinal.  Metab. 77: 1294–1299.

Soliman AT, Darwish A, AL Salim J, A sfour M (1996). Defective growth hormone secretion and hypogonadism in the new syndrome of congenital hypoparathyroidism, growth failure and dysmorphic features, Indian J. Pediatrics. 63(5):679-­‐682.

Teebi AS, Introduction In. Teebi AS Farag TI, eds (1997). Genetic disorders among arab populations, Oxford, Oxford University Press: pages 1-­‐26

Tillmann V,  Buckler JM, Kibirig MS, et al (1997). Biochemical tests in the diagnosis of childhood growth hormone deficiency J. clin. Endocrinal Metab. 82:531_535.

Related Articles

Original Research Articles
Ali Taha A Hassan, Hossam El-Din M Omar, Nagwa M Elsawi and Amira M Ahmed
Evaluation of serum cortisol, growth and thyroid hormones and its relation with lipolysis in non-diabetic obese and diabetic obese subjects attending Sohag Governorate, Egypt
Glo. Adv. Res. J. Med. Med. Sci. April 2016 Vol: 5(4): - [Abstract] [Full Text - PDF] (156 KB)
Kandil A.A., A.E. Sharief and Marwa S. Ahmed
Seed Germination Characters of New and Aging Seed of Some Maize Hybrids as Influenced by Antioxidant and Growth Hormones
Glo. Adv. Res. J. Med. Med. Sci. March 2019 Vol: 8(3): - [Abstract] [Full Text - PDF] (1,683 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Nasir A Al-Jurayyan on Google Scholar
Nasir A Al-Jurayyan on Pubmed
Hala G Omer on Google Scholar
Hala G Omer on Pubmed
Huda A Osman on Google Scholar
Huda A Osman on Pubmed
Reem A Alkhalifah on Google Scholar
Reem A Alkhalifah on Pubmed
Abdulmajeed A Alsubaihin on Google Scholar
Abdulmajeed A Alsubaihin on Pubmed
Hessah M Al-Otaibi on Google Scholar
Hessah M Al-Otaibi on Pubmed
Sharifah T AlIssa on Google Scholar
Sharifah T AlIssa on Pubmed


Viewed 1500
Printed 511
Downloaded 1113
Powered By iPortal Works