Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
November 2018, Vol. 7(9), pp. 172-189
Copyright © 2018 Global Advanced Research Journals
Full Length Research Article
Invasion and parasite subsistence of human cancer
Department of Evolutionary Immunology, Andent Inc., 31 Cove Lane 6a, Brooklyn, New York, 11234, USA
*Corresponding Author E-mail: email@example.com
Accepted 15 November, 2018
Cancer War against the current biggest threat to global human health (1971 - 2xxx) failed dismally because the bankruptcy of its theoretical bases. New insights in cancer biology and origin are sorely needed. The goal of this article is to create the most exhaustive presentation of entirely different hypothesis of xenogamous origin and parasite subsistence of human cancer. Cancern is the genomic parasite spread via intrusion of its causative agent in the genome of affected organism. This article aids the most exhaustive search of the hypothesis evidence. The investigation was based on a multidisciplinary integrative reassessment and reinterpretation of relevant current data about cancer. The main focus was on the consecutive stages of cancer subsistence, beginning from the invasion of victim's genome with cancerous gamete and finishing by sexual transmission of cancerous genome between people. The subsistence of cancer at the expense of substances derived from the body of its prey is crucial for the progression of cancer within the host's body. The subsistence is also supported by the inherent possession by the cancer cells of constitutive immunity to the host's immune defense and cell regulation. These new notions provide framework and landmarks for the location of genomic roots of cancer and encourage new proposals for cancer prevention by voluntary restriction of cancerous fertilization with orientation on non-cancerous genealogies.
Keywords: Cancerous disease, cancerus genealogy, cell regulation, embryogenesis, constitutive immunity, genome intrusion, genome parasite, immune response, parasite invasion of a-pray gene, self-procurement, sexual transmission, xenogamy, selfish genes, xenogamy.
1999-2007 Cancer Incidence and Mortality Data (2007). National Program of Cancer Registries. Betesda, Maryland: USA CDC.
Albiges L, Molinie V, Escudier B (2012). Non- clear cell renal cell carcinoma: does the Mammalian target of rapamycin represent a rational therapeutic target? Oncologist. 17, 1051-1062.
Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, B0rresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjord JE, Foekens JA., Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinski M, Jager N, Jones DT, Jones D, Knappskog S, Kool M, Lakhani SR, Lopez-Otln C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K,
Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt AN, Valdes-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR (2013). Signatures of mutational processes in human cancer. Nature 500: 415-421.
Anonymous (2011). 40 years of the war on cancer. Science 331, 1540-1541.
Bauer KH (1928). Mutationstheorie der Geschswulst-Entstehung. Berlin: Springer.
Baum M, Chaplain M, Anderson A, Douek M, Vaidya JS (1999). Does breast cancer exist in a state of chaos? Eur. J. Can. 35: 886-891.
Briasoulis E, Pavlidis N (1997). Cancer of Unknown Primary Origin. The Oncologist 2: 142152.
Burgasov PN, Rumyantsev SN (1974). Evolution of Clostridiosis [in Russian]. Moscow: Meditsine.
Carmeliet P, Rakesh KJ (2000). Angiogenesis in cancer and other diseases. Nature 407, 249-257.
De Giorgi V, Massi D, Gerlini G, Mannone F, Quercioli E, Carli P (2003). Immediate local and regional recurrence after the excision of a polypoid melanoma: Tumor dormancy or tumor activation? 2003. Dermatologic Surgery 29: 664-667.
De Jong KP, Lont HE, Bijma AM, Brouwers MA, de Vries EG, van Veen ML, Marquet RL, Slooff MJ, Terpstra OT (1995). The effect of partial hepatectomy on tumor growth in rats: in vivo and in vitro studies. Hepatol. 22: 1263-1272.
De Wys WD, Malone WF, Butrum RR, Sestili MA (1986). Clinical trials in cancer prevention. Cancer. 58: 1954-1962.
Demicheli R, Retsky M, Hrushesky WJM, Baum M, Gukas ID (2008). The effects of surgery on tumor growth: a century of investigations. Annals of Oncol. 19: 1821-1828.
Deylgat B, Van Rooy F, Vansteenkiste, Devriendt D, George C (2011). Postsurgery activation of dormant liver micrometastasis: a case report and review of literature. J. Gastrointestinal Cancer 42: 1-4.
Ehrmann RL, Knoth M (1968). Choriocarcinoma: transfilter stimulation of vasoproliferation in the hamster cheek pouch studied by light and electron microscopy. The J. the National Cancer Institute. 41: 1329-1341.
Elias D, De Baere T, Roche A, Ducreux M, Leclere J, Lasser P (1999). During liver regeneration following right portal embolization growth rate of liver metastases is more rapid than that of the liver parenchyma. Br. J. Surg. 86: 784-788.
Folkman J, Watson K, Ingber D, Hanahan D (1989). Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature. 339:58-61.
Garcia-Alonso I, Palomares T, Alonso A, Portugal V, Castro B, Carames J, Mendez J (2003). Effect of hepatic resection on development of liver metastasis. Revista espanola de enfermedades digestivas 95: 765-767.
Gilbert SF (2000). Developmental Biology, 6th. ed. Sunderland, Massachusetts: Sinauer Associates, Inc.
Giraldo-Perez P, Goddard MR (2013). A parasitic selfish gene that affects host promiscuity. Proceedings of the Royal Society B: Biological Sciences 280.
Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, McCall LM, Morrow M (2011). Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. J. the Am. Med. Assoc. pp. 569-575.
Greenblatt M, Shubik P (1968). Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparant chamber technique. The J. the National Cancer Institute 41: 111124.
Hanahan D, Coussens LM (2012). Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 21: 309-322.
Hanahan D, Weinberg RA (2011). Hallmarks of cancer: the next generation. Cell 144: 646-674.
Hanin L (2013). Seeing the invisible: how mathematical models uncover tumor dormancy, reconstruct the natural history of cancer, and assess the effects of treatment. Advances in Experimental Medicine and Biology 734: 261-282.
Hanin L, Korosteleva O (2010). Does extirpation of the primary breast tumor give boost to growth of metastases? Evidence revealed by mathematical modeling. Mathematical Biosciences 223: 133-141.
Ikeda Y, Matsumata T, Takenaka K, Sasaki O, Soejima K, Sugimachi K (1995). Preliminary report of tumor metastasis during liver regeneration after hepatic resection in rats. European J. Surgical Oncol. 21: 188190.
Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE (2013). Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer . Science 339: 543-548.
Lange PH, Hekmat K, Bosl G, Kennedy BJ, Fraley EE (1980). Accelerated growth of testicular cancer after cytoreductive surgery. Cancer 45: 1498-1506.
Levi F, Randimbison L, Te VC, Conconi MM, La Vecchia C (2008). Risk of prostate, breast and colorectal cancer after skin cancer diagnosis. Int. J. Can. 123: 2899-3001.
Mardis ER (2012). Genome sequencing and cancer. Current Opinion in Genetics and Development 22, 245-250.
Marshall E (2011). Cancer Research and the $90 Billion Metaphor. Science 331, 1540-1541.
Marusyk A, Polyak K (2013). Cancer. Cancer cell phenotypes, in fifty shades of grey. Science 339: 528-529.
McCulloch M, Jezierski T, Broffman M, Hubbard A, Turner K, Janecki T (2006). Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers. Integrative Cancer Therapies 5: 30-39.
Milan T, Pukkala E, Verkasalo PK, Kaprio J, Jansen CT, Koskenvuo M, Teppo L (2000). Subsequent primary cancers after basal-cell carcinoma: a nationwide study in Finland from 1953 to 1995. Int. J. Can. 87:283288.
Murchison EP, Wedge DC, Alexandrov LB, Fu, Martincorena I, Ning Z, Tubio JM, Werner EI, Allen J, De Nardi AB, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR (2014). Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage. Science 343: 437-440.
Murgia C, Pritchard JK, Kim SY, Fassati A, Weiss RA (2006). Clonal origin and evolution of a transmissible cancer. Cell 126: 477-487.
Nugent Z, Demers AA, Wiseman MC, Mihalcioiu, Kliewer EV (2005). Risk of second primary cancer and death following a diagnosis of nonmelanoma skin cancer. Cancer Epidemiology, Biomarkers and Prevention 14: 2584-2590.
Pederson P (2011). On Cancer and People. Science 332: 423.
Pockaj BA, Wasif N, Dueck AC, Wigle DA, Boughey JC, Degnim AC, Gray RJ, McLaughlin SA, Northfelt DW, Sticca RP, Jakub JW, Perez EA (2010). Metastasectomy and surgical resection of the primary tumor in patients with stage IV breast cancer: time for a second look? Annals of Surgical Oncol. 17: 2419-2426.
Prehn RT (1993). Two competing influences that may explain concomitant tumor resistance. Cancer Res. 53: 3266-3269.
Quintana E, Piskounova E, Shackleton M, Weinberg D, Eskiocak U, Fullen DR, Johnson T.M, Morrison SJ (2012). Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Science Translational Medicine
Rebbeck CA, Thomas R, Breen M, Leroi AM, Burt A (2009). Origins and evolution of a transmissible cancer. Evolution 63: 2340-2349.
Retsky M, Demicheli R, Hrushesky W, Baum M, Gukas I (2010). Surgery triggers outgrowth of latent distant disease in breast cancer: An inconvenient truth? 2010; 2: 305-37. Cancers 2, 305.
Rosenblatt KA, Wicklund KG, Stanford JL (2001). Sexual factors and the risk of prostate cancer. Am. J. Epidemiol. 153: 1152-1158.
Rumyantsev S (2010). Hypothesis: Toward the origin of cancer epidemics and pathogenesis. J. Carcinogenesis. 9: 1-7.
Rumyantsev S.N (2008a). Cancer, Hereditary Immunity: Fundamental Principles and Exploitation in Life Study and Health Care. pp. 210-212. New York: Nova Biomedical Books.
Rumyantsev S.N (2009a). The Discredit of Cancer Metastasis Science Advisory Board [http://www.scienceboard.net/community/perspectiv es.227.html].
Rumyantsev SN (1997). Chemical ecology and biomolecular evolution. Acta Biotheoretica 45: 6580.
Rumyantsev SN (2003). The intra-individual diversity in senescence. Biogerontol. 4: 171-178.
Rumyantsev SN (2008b). Hereditary Immunity: Fundamental Principles and Exploitation in Life Study and Health Care. New York: Nova Biomedical Books.
Rumyantsev SN (2008c). Phenomenon of Immune Mosaicism, Hereditary Immunity: Fundamental Principles and Exploitation in Life Study and Health Care, pp. 81-102. New York: Nova Science Publishers.
Rumyantsev SN (2009b). The Uniqueness and Ordinariness of Cancer Origin and Pathogenesis: New Epidemiological, Clinical and Preventive Perspectives. J. Clin. Med. Res. 1: 32-36.
Rumyantsev SN (2010a). Bioecology of pleistocenic spurt in anthropogenesis. Int. J. Integrative Bio. 10: 14-21.
Rumyantsev SN (2011). Functions of hereditary immunity and xenogamy in cancer origin and pandemic spread. Open J. Immunol. 1: 27-40.
Rumyantsev SN (2012). Toward the genomic roots of cancer. J. Med. Med. Sci. 3: 638-659.
Rumyantsev SN (2013a). Human Cancer is a Parasite Spread via Intrusion in Genome. Pure and Appl. Biol. 2: 7-16.
Rumyantsev SN (2013b). Human cancer is transmitted via genome. Open J. Genetics 3: 6-11.
Rumyantsev SN., Gerasimov VK (2007). The Origin and Functions of Biodiversity in Infectious and Non-Infectious Diseases, Focus on Biodiversity Research, edited by Schwartz J. pp. 199-300. Nova Science Publishers.
Sarma AV, McLaughlin JC, Wallner LP, Dunn RL, Cooney KA, Schottenfeld D, Montie JE, Wei JT (2006). Sexual behavior, sexually transmitted diseases and prostatitis: the risk of prostate cancer in black men. J. Urol. 176: 1108-1113.
Sharon Begley (2008). Rethinking the War on Cancer. NEWSWEEK, September 16, 2008
Shyman S, Aganoal SS, Sehgal A, Sardana S, Kumar A, Luthra UK (1993). Role of Male Behavior in Cervical Carcinogenesis among Women with One Lifetime Sexual Partner. Cancer 72: 1666-1669.
Siegel R (2011). Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Can. J. for Clinicians 61: 212-236.
Skegg DCG, Corwin PA, Paul C, Doll R (1982). Importance of the male factor in cancer of the cervix. Lancet 2. 581-583.
Soerjomataram I, Coebergh JW (2009). Epidemiology of multiple primary cancers. Methods in Molecular Biol. 471: 85-105.
Soerjomataram I, Louwman WJ, Lemmens VE, Coebergh JW, de Vries E (2008). Are patients with skin cancer at lower risk of developing colorectal or breast cancer? Am. J. Epidemiol. 167: 1421-1429.
Sorin V, Mizrahi A, Ohana P, Ayesh S, Birman T, Hochberg A, Czerniak A (2009). Partial Hepatectomy in rats results in significant growth of liver metastases by increased expression of H19 gene. Cancer Therapy 7: 240-244.
Stratton MR, Rahman N (2008). The emerging landscape of breast cancer susceptibility. Nature Genetics 40: 17-22.
Tisdale MJ (2003). Pathogenesis of cancer cachexia. J. Supportive Oncol. 1: 159168.
Tseng WW, Doyle JA, Maguiness S, Horvai AE, Kashani-Sabet M, Leong SPL (2009). Giant cutaneous melanomas: evidence for primary tumour induced dormancy in metastatic sites? Brit. Med. J. Case Reports. October 5
Van de Stolpe A, den Toonder JMJ (2014). Circulating Tumor Cells: What Is in It for the Patient? A Vision towards the Future. Cancers 6: 1195-1207.
Von Schweinitz D, Fuchs J, Gluer S, Pietsch T (1998). The occurrence of liver growth factor in hepatoblastoma. Eur. J. Pediatric Surg. 8: 133-136.
War on Cancer is a Dismal Failure (2010). NaturalNews.com
Werren JH (2011). Selfish genetic elements, genetic conflict, and evolutionary innovation. Proceedings of the National Academy of Sciences of the United States of America