Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
November 2019, Vol. 8(4), pp. 020-027
Copyright © 2019 Global Advanced Research Journals
DOI: 10.5281/zenodo.3558862

 

Review

Diabetic Cardiomyopathy Pathophysiology and Update on Treatment

Mostafa Q. Alshamiri

Department of Cardiac Science, Faculty of Medicine, King Saud University, Riyadh 11472, Saudi Arabia.

E-mail: mshamiri@hotmail.com; Tel.: +9661504135042; Fax: +966114679472

Accepted 15 November, 2019

The presence of diabetes in HF patients portends worse prognosis than does HF without DM. Heart failure in diabetes mellitus (DM) in the absence of conventional risk factors such as hypertension, coronary artery disease (CAD), and congenital or valvular heart disease, has been defined in the literature as diabetic cardiomyopathy (DCM). The question what are the link between DM and DCM? The answer of this question is not well understood. This review will identify the link between diabetes mellitus and DCM, will also explore the possible mechanisms and triggering factors or associations with emphasis upon the implications of new anti-diabetic treatment on preventing development of heart failure in DM. The keywords used in the literature search were heart failure, diabetes mellitus, cardiovascular disease in DM, diabetic cardiomyopathy and treatment of diabetes with heart failure. These keywords were synced into midline and google search to acquire literature reviews and structured topics in order to deliver significant understanding of the mechanism and factors contributing to the development of DCM. All heart failure secondary to known etiology such as hypertension, valvuler heart disease, coronary artery disease or cardio-myopathy without diabetes mellitus excluded. This literature review identify  several link between diabetes mellitus and heart failure in the absence of conventional risk factors (DCM), it also explore the possible mechanisms and triggering factors or associations with emphasis upon the implications of new anti-diabetic treatment on preventing development of heart failure in diabetic patients. It also give conception on what remedy can change the course of this disease. DCMhas a distinct substrate in DM patients with HF in the absence of known causes ofheart diseases and its factors. All proven evidence-based medicine for its treatment should be taken into consideration. Uses of new anti-diabetic medication may delay or prevent development of DCM. Further clinical studies and basic science advancement will recognize the context of DCM.

Keywards: Diabetes mellitus, Diabetic cardiomyopathy, Heart failure

 

List of abbreviations 

HF: Heart failure, DM: Diabetes mellitus, DCM: Diabetic cardiomyopathy, CAN: Coronary artery disease, MI: Myocardial infarction, ICM: Idiopathic cardio myopathy, PKC: Protein kinase C, ROS: Reactive oxygen species, FA: Fatty acid, FFA: Free fatty acid, LV: Left ventricular, RAAS: Renin Angiotensin Aldosterone System, ACEI: Angiotensin converting enzyme inhibitor, ARBs: Angiotensin receptor blockers, BB: Beta Blocker, TZDs:Thiazolidinediones, DPP-4: Dipeptidyl peptidase 4, SGLT: Sodium Glucose-Linked Transporter 

 

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