Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2014 Special Issue Vol. 3(12), pp. 408-414
Copyright © 2014 Global Advanced Research Journals


Case Report

Esthesioneuroblastoma presenting as diplopia and proptosis in a young female patient. Case report and review of the literature

Dan Andrei Mitrea1*, Ana-Maria Vladila1, Sanda Maria Nica1,2, Ioan Buraga1,2, Gabriela Mihailescu1,2 and Emilia Diaconu3

1Department of Neurology - Colentina Clinical Hospital - Bucharest, Romania
2Carol Davila University of Medicine - Bucharest, Romania
3Department of Diagnostic Imaging - Regina Maria Clinic - Bucharest, Romania

*Corresponding Author E-mail:; Telephone: +40 723 226 233; Fax: +40 21 222 13 68

Accepted 09 December, 2014


Esthesioneuroblastoma is a rare, primary sinonasal malignant tumor with an incidence between 3%-6% of all the sinonasal malignancies and estimated occurrence rate of 4 in 10 million individuals. We report the case of a 36 years old female patient admitted for progressive lower gaze diplopia and proptosis, diagnosed using Computer Tomography (CT), Magnetic Resonance Imaging (MRI) and histopathology examination with highly differentiated grade C esthesioneuroblastoma. Treatment included total surgical removal via endonasal approach and adjuvant radiotherapy with good prognostic. Diplopia and proptosis are rare presentations of esthesioneuroblastomas; a biopsy should always be performed in case of a nasosinusal infiltrating tumor. The current staging system, Kadish and Hyam’s scales proved to be useful instruments in choosing the appropriate treatment and also in predicting the survival rate of these patients. Long-term follow-up is mandatory due to the extended interval for disease recurrence, sometimes up to 10 years since the diagnosis.

Keywords: esthesioneuroblastoma, sinonasal malignant tumor, diplopia, proptosis,  chronic sinusitis, endoscopic nasal surgery, Kadish scale, Hyam’s scale


Related Articles

Original Research Article
Amin Elahifar, Mohammad Taheri, Mohammad Reza Mirinezhad, Arezou Sayad, Rezvan Noroozi, Maryam Eghbali and Mehrdokht Mazdeh
What is the first clinical manifestation in multiple sclerosis patients?
Glo. Adv. Res. J. Med. Med. Sci. September 2015 Vol: 4(9): - [Abstract] [Full Text - PDF] (107 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Dan Andrei Mitrea on Google Scholar
Dan Andrei Mitrea on Pubmed
Ana-Maria Vladila on Google Scholar
Ana-Maria Vladila on Pubmed
S on Google Scholar
S on Pubmed
a Maria Nica on Google Scholar
a Maria Nica on Pubmed
Ioan Buraga on Google Scholar
Ioan Buraga on Pubmed
Gabriela Mihailescu on Google Scholar
Gabriela Mihailescu on Pubmed
Emilia Diaconu on Google Scholar
Emilia Diaconu on Pubmed


Viewed 1374
Printed 584
Downloaded 635
Powered By iPortal Works