Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2015 Special Issue Vol. 4(12), pp. 556-561
Copyright © 2015 Global Advanced Research Journals

 

Full Length Research Paper

Morphometric analyses of Substantia Nigra Pars Compacta, temporal lobes and lateral ventricles in Schizophrenia Disease: MRI Study

Tag Alsir Altayeb Beshier Ahmed1, Caroline Edward Ayad2*, Hussein Ahmed Hassan3 and Elsafi Ahmed Abdalla2

1Department of Radiology, Military Hospital, Khartoum-Sudan.
2College of Medical Radiological Science, Sudan University of Science and Technology, Khartoum-Sudan
3College of Medical Radiological Science, Karry University, Khartoum-Sudan.

*Corresponding Author E-mail: carolineayad@yahoo.com, carolineayad@sustech.edu; Tel: +249183771818; Mobile: +249922044764; Fax: +249183785215

Accepted 09 December, 2015

Abstract

Schizophrenia is a serious mental disorder that affects several brain functions. MRI technology has enabled studies of brain anatomy in patients with schizophrenia aimed at understanding more about the substantia nigra pars compacta, lateral ventricles temporal lobes in schizophrenia disease. We prospectively examined 18 patients with schizophrenia (M: F = 14∶4, mean age: 44.77 years) and 50 healthy controls. Using a 1.5T MRI unit, we obtained oblique T1-weighted axial images. We measured the length and width for the substantia nigra (SN), lateral ventricles and temporal lobes as well as identified signal intensity which was compared between patients and healthy controls using unpaired t-tests. Results showed that the signal intensity in schizophrenic patients differ from normal healthy subjects. The measured values of (SN) and Lateral ventricles in patients were significantly greater than those in healthy controls at p<0.01. Furthermore, no difference in temporal lobes between schizophrenia patients and controls were observed. The research shows that schizophrenia has neuro- anatomical correlation that can be seen by studying MR images.

Keywords: Morphometric analyses, Nigra Pars Compacta, temporal lobes, lateral ventricles, Schizophrenia, MRI

 

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