Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2015 Special Issue Vol. 4(12), pp. 538-545
Copyright © 2015 Global Advanced Research Journals

 

Full Length Research Paper

Thrombophilic risk factors for non-malignant portal vein thrombosis in HCV related cirrhosis

Shahira A El-Etreby1*, Seham Seif1, Rokiah Anwar1, Monir Bahgat1, Hanan Azzam2, Lamia Ibrahem2, Hanaa Abdel Masseih2, Mona M Arafa3, Mohamed Elrakhawy4 and Nihal Elbatouty4

1Department of Hepatology and Gastroenterology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
2Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
3Department of Tropical Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
4Department of Radiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

 

*Corresponding Author E-mail: aly_shahira@yahoo.com; Telephone:   +2 01143543995;   Fax:  +2-050-2230129

Accepted 02 December, 2015

Abstract

The aim of the study to assess occurrence of non-malignant portal vein thrombosis (PVT) in HCV-related cirrhosis in relation to thrombophilic risk factors. This case control study enrolled 42 patients with HCV related cirrhosis subdivided into PVT group (n=20) and non-PVT group (n=22). Laboratory investigations were done to assess liver function as well as thrombophilic profile. Platelet count was statistically significantly lower in PVT group compared to non PVT group (p=0.03). There was no correlation between this low platelet count and presence of antiphospholipid antibodies (IgG or IgM; p=0.71 and 0.85, respectively) or lupus anticoagulant antibodies (p=0.26). Although the level of anti-thrombin III (AT-III) was within the normal range (70-120%) in both groups, it was statistically lower in PVT group (90.65±17.75 vs 114.27±22.51, p<0.001). There was a statistically significant difference in positive D-dimer test result in PVT group when compared to non-PVT group (80% vs 45.5% respectively, X2=5.301, p=0.021). On logistic regression analysis, risk for PVT increases by 0.95 for every one percent decline in AT-III (B=-.053, p=0.002) and by 4.8 folds in cases with positive D-dimer (B=1.569, p=0.026). On the other hand, INR, APTT, lupus anticoagulant, protein C, protein S, protein C global (PCG) and PCG-FV (protein C global-Factor V) had no statistically significant difference between the two groups (p >0.05). The most important independent predictors for non- malignant PVT in HCV-related cirrhosis seem to be the level of AT III as well as the presence of positive D-dimer.

Keywords: Portal vein thrombosis, liver cirrhosis, antithrombin III, D-dimer, protein S, protein C, protein C global, PCG-FV, antiphospholipid antibodies.

 

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