Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2016 Special Issue Vol. 5(12), pp. 292-303
Copyright © 2016 Global Advanced Research Journals

Full Length Research Paper  

Histological Study on the Protective Effect of Stem Cells and ginger on Isoproterenol Induced Myocardial Infarction in Male Albino Rats

Mohamed Salah Elgendy

Assistant Professor of Histology, Faculty of Medicine, Fayoum University. Fayoum, Egypt, Postal code: 63514

E-mail: msg01@fayoum.edu.eg/ drmohgendy@hotmail.com; Phone: +201005396843; Fax: +20846302350

Accepted 12 December, 2016

Abstract

Till now no effective therapy for myocardial infarction is available, each of ginger extract and stem cell therapy were reported to be beneficial in ameliorating pathological progress of myocardial infarction. In this work we compared each of them and their combination on myocardial infarction. Forty male albino rats were divided into control group and Isoproterenol induced myocardial infarction group that was further subdivided into untreated infarction group, ginger treated group, Mesenchymal Stem Cells treated group and combined ginger with Mesenchymal Stem Cells treated group. Immunohistochemical staining for laminin and cardiac tropomyoscin were applied on cardiac histological sections. Co-injection of Mesenchymal Stem Cells and ginger has a better protective effect on myocardial infarction in rats than either one alone as the heart appeared to be near normal condition as regard histological, immunohistochemical with laminin and cardiac tropomyoscin, while  there was moderate protective effect of Mesenchymal Stem Cells or ginger when used alone. Conclusions: This mode of protection, if proved to be effective in human, may provide a perfect way to decrease the high rate of mortality and morbidity due to coronary insufficiency and myocardial infarction.

Keywords: Mesenchymal Stem Cells, ginger, laminin, tropomyoscin, myocardial infarction, Isoproterenol.