Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2017 Special Issue Vol. 6(12), pp. 316-319
Copyright © 2017 Global Advanced Research Journals
Development and Clinical Evaluation of Rapid Diagnostic Kit for Hemorrhagic Fever with Renal Syndrome
Dong-Hoon Shin1, Sungman Park2, Young-Jin Kim2, Sora Kim3, Min Soo Kim2, Soo-Dong Woo4 and Yoon-Won Kim5*
1Department of Laboratory Medicine, College of Medicine, Hallym University, Chuncheon, Republic of Korea
2Institute of Medical Science, School of Medicine, Hallym University, Chuncheon, Republic of Korea
3Industry-Academic Cooperation Foundation, Hallym University, Chuncheon, Republic of Korea
4Department of Agricultural Biology, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, Republic of Korea
5Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea
*Corresponding Author E-mail: firstname.lastname@example.org; Tel.: +82 33 248 2633; Fax: +82 33 241 1664
Accepted 21 December, 2017
Hemorrhagic fever with renal syndrome (HFRS) is one of the acute febrile illnesses. This study has analysed ‘Immune Med Hanta Rapid Kit’, a medical device for in vitro diagnosis of HFRS using immunochromatographic assay. This kit was evaluated by the test of the IgM and IgG to the Hantavirus. In a clinical evaluation with 194 specimens (91 HFRS, 48 other infectious diseases, and 55 healthy controls), the kit was shown 96.7 % sensitivity and 97.1 % specificity. These results demonstrate that this kit is the potentially useful diagnostic device which can perform a rapid, accurate, and simple diagnosis of HRFS clinically.
Keywords: Rapid Diagnostic Kit, Immunochromatographic assay, HFRS, Nucleocapsid protein, Baculovirus expression
Bi Z, Formenty PB, Roth CE (2008). Hantavirus infection: a review and global update. J. Infect. Dev. Ctries. 2(1):3-23.
Escadafal C, Avsic-Zupanc T, Vapalahti O, Niklasson B, Teichmann A, Niedrig M, et al (2012). Second external quality assurance study for the serological diagnosis of hantaviruses in Europe. PLoS Negl. Trop. Dis. 6(4):e1607.
Jiang H, Du H, Wang LM, Wang PZ, Bai XF (2016). Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. Front Cell Infect. Microbiol. 6:178.
Jonsson CB, Figueiredo LT, Vapalahti O (2010). A global perspective on hantavirus ecology, epidemiology, and disease. Clin. Microbiol. Rev. 23(2):412-441.
Kim GW, Lee WJ, Hong WK, Lee SH, Lee CY, Lee MG, et al (2009). A Correlation between Pulmonary Involvement of Acute Febrile Illness with High Incidence during the Fall and C-reactive Protein. Tuberc. Respir. Dis. 66(2):116-121.
Kim HY (2009). Hemorrhagic Fever with Renal Syndrome. Infect. Chemother. 41(6):323-332.
Kim JH (2011). Infectious diseases in children and adolescents in the Republic of Korea; Past & recent status. Korean J. Pediatr. 54(12):489-500.
Lagerqvist N, Hagstrom A, Lundahl M, Nilsson E, Juremalm M, Larsson I, et al (2016). Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. J. Clin. Microbiol. 54(5):1335-1339.
McCaughey C, Hart CA (2000). Hantaviruses. J. Med. Microbiol. 49(7):587-599.
Noh JY, Cheong HJ, Song JY, Kim WJ, Song KJ, Klein TA, et al (2013). Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period. J. Clin. Virol. 58(1):11-17.
Pettersson L, Klingstrom J, Hardestam J, Lundkvist A, Ahlm C, Evander M (2008). Hantavirus RNA in saliva from patients with hemorrhagic fever with renal syndrome. Emerg. Infect. Dis. 14(3):406-411.
Wang CY, Zhang HH, Yu SL, Zhu CB (2007). Detection of circulating antigen with a MAb-based sandwich-ELISA and its comparison with specific IgM detection in sera of patients with hemorrhagic fever with renal syndrome. Hybridoma (Larchmt). 26(1):42-45.
Wichmann D, Slenczka W, Alter P, Boehm S, Feldmann H (2001). Hemorrhagic fever with renal syndrome: diagnostic problems with a known disease. J. Clin. Microbiol. 39(9):3414-3416.
Wu X, Lu Y, Zhou S, Chen L, Xu B (2016). Impact of climate change on human infectious diseases: Empirical evidence and human adaptation. Environ. Int. 86:14-23.
Yoshimatsu K, Arikawa J (2014). Antigenic properties of N protein of hantavirus. Viruses. 6(8):3097-109.
Zou LX, Chen MJ, Sun L (2016). Haemorrhagic fever with renal syndrome: literature review and distribution analysis in China. Int. J. Infect. Dis. 43:95-100.
- Dong-Hoon Shin on Google Scholar
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- Sungman Park on Google Scholar
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- Young-Jin Kim on Google Scholar
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- Sora Kim on Google Scholar
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- Min Soo Kim on Google Scholar
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- Soo-Dong Woo on Google Scholar
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