Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2017 Special Issue Vol. 6(12), pp. 327-329
Copyright © 2017 Global Advanced Research Journals
Full Length Research Paper
Hematological Changes Induced by Heavy Cigarette Smoking
Mahmoud Mohamed Elgari
Medical laboratories Technology Department, Faculty of Applied Medical Sciences, Taibah University, Al - Medinah, Saudi Arabia.
Accepted 27 November, 2017
Cigarette smoking considered to be as a major cause of deaths from lung cancer and cardiovascular disease. Variable hematological changes occur in smokers. The aim of this study to estimate the effects of cigarette smoking on hematological values. The study included sixty subjects 40 smokers and 20 non-smokers. Smokers categories base on number of cigarettes per day for at least 3 years. Complete blood cell count was analyzed by automatic blood cell counter Sysmex 21, to assess hemoglobin (Hb). packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell (WBC), red blood cell (RBC) and platelets (Plt) counts. The present study revealed significantly increased in Hemoglobin level (P = 0.001), PCV (P = 0.003), MCH (P value = 0.005) MCHC (P = 0.001). RBC count (P = 0.004), WBC count (P = 0.002) respectively. Our results did not show differences related to the number of cigarettes smoked per a day. In conclusion, heavy cigarette smoking lead to gross changes in hematological values leading to risk for developing , secondary polycythemia, pulmonary and/or cardiovascular diseases.
Keywords: Cigarette smoking, Hematological values, Polycythemia
Aitchison R, Russell N (1988). Smoking - a major cause of polycythaemia. J. the Royal Society of Med. 81(2):89–91. [PMC free article] [PubMed]
Al-Dahr MHS (2010). Impact of Smoking on Platelet, Coagulation and Lipid Profile in Young Male Subjects. World Appl. Sci. J. 11(1):118–123.
Anandha Lakshmi S, Anandhi Lakshmanan, Ganesh Kumar P, Saravanan AJ (2014). Clin. Diagn. Res. Effect of Intensity of Cigarette Smoking on Haematological and Lipid Parameters. 8(7): BC11–BC13. PMCID: PMC4149063
Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka-Karna J, Radziwon P, Lipska A (2006). Thromb Res. Does smoking affect thrombocytopoiesis and platelet activation in women and men?. 118(2):199-204. PMID: 16139337
Erhabor O, Isaac IZ. Ahmed HM, Yakubu A, Okwesili AN, et al (2013). The Effect Of Cigarette Smoking On Some haematological indices in Sokoto, Nigeria. Br. J. Med. Health Sci. 1:27-36.
Hassan A Almarshad, Fathelrahman M Hassan (2012). The Hemorheological properties of blood among Saudi male Smokers in Sakaka city, Aljouf, Saudi Arabia. South Asian J. Family Med. 3:14-17
Haufroid V, Hotz P, Carbonnelle P, Lauwerys RJ (1997). Relationships between smoking habits, smoking-associated hematological changes, and urinary benzene metabolites. Toxicol. Environ. Health. 52(1):1-17.PMID: 9269319
Ivan A Lopez, Dora Acuna, Luis Beltran-Parrazal, Ivan E Lopez, Abhimanyu Amarnani, Max Cortes, John Edmond (2009). Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air). BMC Neurosci. 10: 53. doi: 10.1186/1471-2202-10-53 PMCID: PMC2700113
Jane A Leopold, Joseph Loscalzo (2009). Oxidative Risk for Atherothrombotic Cardiovascular Disease. PMCID: PMC2797369
Jayballabh Kumar, Gaurav Kumar, Abhishek Sharma, Farhan Ahmad Khan, Sanjeev Sharma (2013). The Effect Of Smoking On The Blood Parameters of Young Adults. J. Clin. Diagn. Res. 6:1244-1247.
Jena SK, Purohit KC, Misra AK (2013). Effect of Chrnoic Smoking on Hematological Parameteres. Int. J. Cur. Res. 5(2):279–82.
Johnson MD, Schilz J, Djordjevic MV, Rice JR, Shields PG (2009). Evaluation of In Vitro Assays For Assessing the Toxicity of Cigarette Smoke and Smokeless Tobacco - Clin. Chest Med. 18(12):3263-304. PMC 2013 Dec 16. PMID:19959677 Free PMC Article
Kondo H, Kusaka Y, Morimoto K, Sangyo Igaku (1993). Effects of lifestyle on hematologic parameters; I. Analysis of hematologic data in association with smoking habit and age]. 35(2):98-104.PMID:8510349
Majid Sirati-Sabet, Mohammad Kazemi-Arababadi, Saeideh Nabati, Gholamreza Asadikaram (2016). Effects of Opium Addiction and Cigarette Smoking on Hematological Parameters- Gholamabbas Shahabinejad, MSc Addict Health. 8(3): 179–185. PMCID: PMC5422014
Mohammed Hossain, Peter Mazzone, William Tierney, Luca Cucullo (2011). In Vitro Assessment of Tobacco Smoke Toxicity at the BBB: Do Antioxidant Supplements Have a Protective Role? BMC Neurosci. 12: 92.PMCID: PMC3196733
Noble RC, Penny BB (1975). Comparison of leukocyte count and function in smoking and nonsmoking young men. Infect. Immun. 12(3): 550–555. PMCID: PMC415322
Pooja Naik, Luca Cucullo (2015). Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products Am. J. Physiol. Lung Cell Mol. Physiol. 309(12): L1398–L1409. PMCID: PMC4628383
Qiangwei Fu, Sean P Colgan, Carl Simon Shelley (2016). The Force that Drives Chronic Kidney Disease. Clin. Med. Res. Hypoxia. 14(1): 15–39. 1282 - PMCID: PMC485145'
Shah BK, Nepal AK, Agrawal M, Sinha AK (2012). The effects of cigarette smoking on hemoglobin levels compared between smokers and non-smokers. Sunsari Technical College J. 1(1):42–44.
Temperance R Rowell, Robert Tarran (2015). Will chronic e-cigarette use cause lung disease? Am. J. Physiol. Lung Cell Mol. Physiol. 309(12): L1398–L1409. PMCID: PMC4683316