Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2017 Special Issue Vol. 6(12), pp. 341-351
Copyright © 2017 Global Advanced Research Journals


Full Length Research Paper

Revisiting the phenomenon of concomitant tumor resistance and its impact on established metastases of murine and human origin

Ariel Strazza1 Daniela R. Montagna1, Mónica Aixala2, Roberto P. Meiss3, Paula Chiarella1 and Raúl A. Ruggiero1

1Department of Experimental Oncology, IMEX-CONICET, Academia Nacional de Medicina de Buenos Aires, Argentina.
2Central Laboratory of ClinicalAnalysis, Academia Nacional de Medicina de Buenos Aires, Argentina.
3Department of Pathology, Instituto de Estudios Oncológicos,Academia Nacional de Medicina de Buenos Aires, Argentina.

*Corresponding Author E-mail:; Telephone: 54-11-4805-3411 

Accepted 8 December, 2017


Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host inhibits the growth of secondary tumor implants. The relevance of CR to mechanisms of metastases control has been highlighted by numerous observations showing that the removal of human and murine tumors may be followed by an abrupt increase in metastatic growth. This body of evidence suggests that, upon certain circumstances, a primary tumor would exert a controlling action on its metastases that can be considered as natural secondary tumor implants spontaneously developed during the primary tumor growth. In this article we revised both former and recent evidence accounting for this fact in both experimental and clinical settings and discussed the situations in which tumor removal would be or would not be recommended. In addition, we analyzed the different mechanisms historically proposed to explain CR especially focusing on the last investigations of our laboratory concerning the importance of tyrosine isomers as mediators of the phenomenon of CR and on their capacity to inhibit established metastases of both murine and human origin. Our investigations aimed to elucidate the molecular basis of the phenomenon of CR might stimulate the design of new strategies aimed to limit the development of metastases, an issue of critical importance for patients afflicted by malignant diseases.

Keywords: Metastases, concomitant tumor resistance, murine and human tumors, tyrosine isomers.



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