Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2017 Special Issue Vol. 6(12), pp. 320-326
Copyright © 2017 Global Advanced Research Journals
Full Length Research Paper
The effect of gender on transcranial direct current stimulation post-treatment results in stroke patients with aphasia
Karagounis Panagiotis* and Vissarakis George
Filoktitis Rehabilitation Center, Koropi-Attica, Greece
*Corresponding Author E-mail: firstname.lastname@example.org; Phone: +306945702423
Accepted 05 December, 2017
The therapeutic method of transcranial direct current stimulation (tDCS) has been proposed as a safe complementary neuromodulating technique for improving speech disorders in patients after stroke. In the current study we examined the effect of tDCS over inferior frontal gyrus area in 8 chronic post-stroke aphasic female and male patients (4 female and 4 male). The therapeutic protocol consists of the assessment of picture naming (accuracy) before and immediately after anodal type tDCS (2 mA, 20 min) stimulation-in combination with speech therapy, compared to the control group that only followed speech therapy (8 patients, 4 female and 4 male). The post-treatment values of picture naming (13.76 ± 2.12) after treatment with tDCS and speech therapy were statistically improved in the experimental group compared to the control group (11.14±1.27, p=0.04), where additional statistical significance was recorded in post-treatment values between male and female participants, where female patients presented statistically significant major improvement compared to the male patients (female 14.89±1.96 vs male 12.44±1.32 respectively, p=0.04). Therapeutic session with tDCS can be used as a safe and effective complementary method for the treatment of speech disorders following a stroke, where the female patients seem to present a better response to the treatment.
Keywords: Transcranial direct current stimulation, Speech disorders, Stroke patients, Neurorehabilitation
Ardolino G, Bossi B, Barbieri S, et al (2005). Non-synaptic mechanisms underlie the after-effects of cathodal transcutaneous direct current stimulation of the human brain. J. Physiol. 568:653–663.
Baker JM, Rorden C, Fridriksson J (2010). Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke. 41:1229-1236.
Cattaneo Z, Pisoni A, Papagno C (2011). Transcranial direct current stimulation over Broca’s region improves phonemic and semantic fluency in healthy individuals. Neuroscience. 183:64-70.
Chaieb L, Antal A, Paulus W (2008). Gender-specific modulation of short-term neuroplasticity in the visual cortex induced by transcranial direct current stimulation. Vis. Neurosci. 25(1):77-81.
De Renzi E, Faglioni P (1978). Normative data and screening power of a shortened version of the Token Test. Cortex. 14(1):41-49.
De Tomasso M, Invitto S, Ricci K, Lucchese V, Delussi M, Quattromini P, Bettocchi S, Pinto V, Lancioni G, Livrea P, Cicinelli E (2014). Effects of anodal TDCS stimulation of left parietal cortex on visual spatial attention tasks in men and women across menstrual cycle. Neurosci. Lett. 574:21-25.
Fertonani A, Rosini S, Cotelli M, Rossini PM, Miniussi C (2010). Naming facilitation induced by transcranial direct current stimulation. Behav. Brain Res. 208:311-318.
Fregni F, Boggio PS, Nitsche M, Bermpohl F, Antal A, Feredoes E, et al (2005). Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp. Brain Res. 166:23-30.
Fridriksson J, Bonilha L, Baker JM, Moser D, Rorden C (2010). Activity in preserved left hemisphere regions predicts anomia severity in aphasia. Cereb. Cortex. 20:1013-1019.
Fridriksson J, Richardson JD, Baker JM, Rorden C (2011). Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study. Stroke. 42:819-821.
Gandiga PC, Hummel FC, Cohen LG (2006). Transcranial DC stimulation (tDCS): a tool for double-blind sham-controlled clinical studies in brain stimulation. Clin. Neurophysiol. 117:845-850.
Gartside IB (1968). Mechanisms of sustained increases of firing rate of neurons in the rat cerebral cortex after polarization: reverberating circuits or modification of synaptic conductance? Nature. 220:382–383.
Giglia G, Mattaliano P, Puma A, Rizzo S, Fierro B, Brighina F (2011). Neglect-like effects induced by tDCS modulation of posterior parietal cortices in healthy subjects. Brain Stimul. 4:294-299.
Ginex V, Veronelli L, Vanacore N, Lacorte E, Monti A, Corbo M (2017). Motor recovery in post-stroke patients with aphasia: the role of specific linguistic abilities. Top Stroke Rehabil. 24(6):428-434.
Heiss WD, Kessler J, Thiel A, Ghaemi M, Karbe H (1999). Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia. Ann. Neurol. 45:430-438.
Heiss WD, Thiel A (2006). A proposed regional hierarchy in recovery of post-stroke aphasia. Brain Lang. 98: 118-123.
Holland R, Crinion J (2012). Can tDCS enhance treatment of aphasia after stroke? Aphasiol. 26:1169–1191.
Islam N, Aftabuddin M, Moriwaki A, et al (1995). Increase in the calcium level following anodal polarization in the rat brain. Brain Res. 684:206–208.
Jordan LC, Hillis AE (2006). Disorders of speech and language: aphasia, apraxia and dysarthria. Curr. Opin. Neurol. 19:580-585.
Kang EK, Kim YK, Sohn HM, Cohen LG, Paik NJ (2011). Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca’s homologue area. Restor. Neurol. Neurosci. 29:141-152.
Karagounis P, Vissarakis G (2017). The effect of simultaneous transcranial direct current stimulation and speech therapy treatment in stroke patients with aphasia. J. Med. Med. Res. 24(3):1-8.
Karbe H, Thiel A, Weber-Luxenburger G, Herholz K, Kessler J, Heiss WD (1998). Brain plasticity in poststroke aphasia: what is the contribution of the right hemisphere? Brain Lang. 64:215-230.
Liebetanz D, Nitsche MA, Tergau F, Paulus W (2002). Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain. 125:2238-2247.
Martin AK, Huang J, Hunoid A, Meinzer M (2017). Sex mediates the effects of high-definition transcranial direct current stimulation on mind reading. Neuroscience. 366:84-94.
Merzagora AC, Foffani G, Panyavin I, et al (2010). Prefrontal hemodynamic changes produced by anodal direct current stimulation. Neuroimage. 49: 2304–2310.
Monti A, Cogiamanian F, Marceglia S, Ferrucci R, Mameli F, Mrakic-Sposta S, Vergari M, Zago S, Priori A (2008). Improved naming after transcranial direct current stimulation in aphasia. J. Neurol. Neurosurg. Psychiatry. 79(4):451-453.
Nicholas ML, Helm-Estabrooks N, Ward-Lonergan J, Morgan AR (1993). Evolution of severe aphasia in the first two years post onset. Arch. Phys. Med. Rehabil. 74:830-836.
Nitsche MA, Cohen LG, Wassermann EM, Priori A, Lang N, Antal A, et al (2008). Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 1: 206-223.
Nitsche MA, Fricke K, Henschke U, et al (2003). Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. J. Physiol. 553:293–301.
Nitsche MA, Paulus W (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J. Physiol. 527:633-639.
Okamoto M, Dan H, Sakamoto K, Takeo K, Shimizu K, Kohno S, et al (2004). Three-dimensional probabilistic anatomical cranio-cerebral correlation via the international 10-20 system oriented for transcranial functional brain mapping. Neuroimage. 21:99-111.
Priori A, Berardelli A, Rona S, Accornero N, Manfredi M (1998). Polarization of the human motor cortex through the scalp. Neuroreport. 9:2257-2260.
Robey RR (1994). The efficacy of treatment for aphasic persons: a meta-analysis. Brain Lang. 47:582-608.
Robey RR (1998). A meta-analysis of clinical outcomes in the treatment of aphasia. J. Speech Lang Hear Res. 41:172-187.
Schlaug G, Renga V, Nair D (2008). Transcranial direct current stimulation in stroke recovery. Arch. Neurol. 65:1571-1576.
Sparing R, Dafotakis M, Meister IG, Thirugnanasambandam N, Fink GR (2008). Enhancing language performance with non-invasive brain stimulation: a transcranial direct current stimulation study in healthy humans. Neuropsychologia. 46:261-268.
Stagg CJ, Nitsche MA (2011). Physiological basis of transcranial direct current stimulation. Neuroscientist. 17:37–53.
Titushkin I, Cho M (2009). Regulation of cell cytoskeleton and membrane mechanics by electric field: role of linker proteins. Biophys. J. 96:717–728.
Trollinger DR, Isseroff RR, Nuccitelli R (2002). Calcium channel blockers inhibit galvanotaxis in human keratinocytes. J. Cell Physiol. 193:1–9.
Vines BW, Cerruti C, Schlaug G (2008). Dual-hemisphere tDCS facilitates greater improvements for healthy subjects’ non-dominant hand compared to uni-hemisphere stimulation. BMC Neurosci. 9:103.
Warburton E, Price CJ, Swinburn K, Wise RJ (1999). Mechanisms of recovery from aphasia: evidence from positron emission tomography studies. J. Neurol. Neurosurg. Psych. 66:155-161.
You DS, Kim DY, Chun MH, Jung SE, Park SJ (2011). Cathodal transcranial direct current stimulation of the right Wernicke’s area improves comprehension in subacute stroke patients. Brain Lang. 119:1-5.
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