Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2018 Special Issue, Vol. 7(10), pp. 202-206
Copyright © 2018 Global Advanced Research Journals

 

Case Report

Rare Association of Dermatomyositis with Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder

Gabriela Puziski Ferreira de Melo1, Marcelo Magalhães da Silveira Neto2, Mariana Pires de Sá Valeriano3, Vanessa Miranda Pereira Fausto4, Rafaella Lima Borges de Mendonça5 and Lucas José Sá da Fonseca6*

1Medical Resident of Dermatology, Hospital Universitário Professor Alberto Antunes, Federal University of Alagoas, Maceió, Alagoas, Brazil.
2Medical Resident of Pathology, Hospital Universitário Professor Alberto Antunes, Federal University of Alagoas, Maceió, Alagoas, Brazil.
3Medical Doctor (Dermatologist), Hospital Universitário Professor Alberto Antunes, Federal University of Alagoas, Maceió, Alagoas, Brazil.
4Medical Doctor (Rheumatologist), Hospital Universitário Professor Alberto Antunes, Federal University of Alagoas, Maceió, Alagoas, Brazil.
5Medical Doctor (Pathologist), Hospital Universitário Professor Alberto Antunes, Federal University of Alagoas, Maceió, Alagoas, Brazil.
6Medical Resident of Rheumatology, Hospital Universitário Professor Alberto Antunes, Federal University of Alagoas, Maceió, Alagoas, Brazil

*Corresponding Author E-mail: lucasjsdf@hotmail.com; Phone: +55 82 3202-3935 

Accepted 27 December, 2018

Abstract

Dermatomyositis is an inflammatory myopathy of not fully understood etiology that may be associated with neoplasms. Representing a systemic autoimmune disease, the hallmarks of its clinical presentation are seen as cutaneous and skeletal muscle manifestations. The main cutaneous signs are represented by heliotrope and the Gottron's papules, while the muscular compromise is observed by proximal weakness and dysphagia. Diagnosis relies upon clinical history, physical examination and laboratory tests, and the first-line treatment is based on the use of systemic corticosteroid. The present manuscript reports a case of paraneoplastic dermatomyositis secundary to mixed adenoneuroendocrine carcinoma, an extremely rare association. Considering the potential aggressiveness of such tumor, the screening of occult neoplasms in dermatomyositis should also include the gallbladder assessment, aiming the early diagnosis and prompt specific treatment. Physicians must be aware of such possible association, once early diagnosis positively impacts in prognosis.

Keywords: Dermatomyositis, gallbladder, paraneoplastic, mixed adenoneuroendocrine carcinoma. 

List of Abbreviations

MANEC; mixed adenoneuroendocrine carcinoma.

 

References

Acosta AM, Hamedani FS, Kajdacsy-Balla A, et al (2015). Primary mixed adenoneuroendocrine carcinoma of the gallbladder in a 55-year-old female patient: a case report and review of the literature. Int. J. Surg. Pathol. DOI: 10.1177/1066896915580433.

Dalakas MC (2015). Inflammatory Muscle Disease. N. Engl. J. Med. 372(18): 1734-1747.

Harada K, Sato Y, Ikeda H, et al (2012). Clinicopathologic study of mixed adenoneuroendocrine carcinoma of hepatobiliary organs. Virchows Arch. 460: 281-289.

Junior WB, Chiacchio ND, Criado PR (2014). Tratado de Dermatologia. 2nd edition. Atheneu; v.1, p. 695-713.

Jurcic, P (2015). Dermatomyositis as the first manifestation of gallbladder adenocarcinoma: case report and literature overview. World J. Surg. Oncol. 13:127.

Kamboj M, Gandhi JS, Gupta G, et al (2015). Neuroendocrine Carcinoma of gallbladder: a series of 19 cases with review of literature. J. Gastrintest Canc. DOI 10.1007/s12029-015-9745-9.

McGrath ER, Doughty CT, Amaro AA (2018). Autoimmune Myopathies: Updates on Evaluation and Treatment. Neurotherapeutics. 15:976-994.

Meguro Y, Fukushima N, Koizumi M, et al (2014). A case of mixed adenoneuroendocrine carcinoma of the gallbladder arising from an intracystic papillary neoplasm associated with pancreaticobiliary maljunction. Pathol. Int. 64:465-471.

Mondolfi AEP, Slova D, Fan W, et al (2011). Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor? Pathol Int. 61:608-614.

Qiang JK, Kim WB, Baibergenova A, et al (2016). Risk of Malignancy in Dermatomyositis and Polymyositis. J. Cutaneous Med. Surg. 21(2):131–136.

Sasaki H, Kohsaka H (2018). Current diagnosis and treatment of polymyositis and dermatomyositis. Modern Rheumatol. DOI: 10.1080/14397595.2018.1467257.

Song W, Chen W, Zhang S, et al (2012). Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy. Diagnostic Pathol. 7:163.

Acosta AM, Hamedani FS, Kajdacsy-Balla A, et al (2015). Primary mixed adenoneuroendocrine carcinoma of the gallbladder in a 55-year-old female patient: a case report and review of the literature. Int. J. Surg. Pathol. DOI: 10.1177/1066896915580433.

Dalakas MC (2015). Inflammatory Muscle Disease. N. Engl. J. Med. 372(18): 1734-1747.

Harada K, Sato Y, Ikeda H, et al (2012). Clinicopathologic study of mixed adenoneuroendocrine carcinoma of hepatobiliary organs. Virchows Arch. 460: 281-289.

Junior WB, Chiacchio ND, Criado PR (2014). Tratado de Dermatologia. 2nd edition. Atheneu; v.1, p. 695-713.

Jurcic, P (2015). Dermatomyositis as the first manifestation of gallbladder adenocarcinoma: case report and literature overview. World J. Surg. Oncol. 13:127.

Kamboj M, Gandhi JS, Gupta G, et al (2015). Neuroendocrine Carcinoma of gallbladder: a series of 19 cases with review of literature. J. Gastrintest Canc. DOI 10.1007/s12029-015-9745-9.

McGrath ER, Doughty CT, Amaro AA (2018). Autoimmune Myopathies: Updates on Evaluation and Treatment. Neurotherapeutics. 15:976-994.

Meguro Y, Fukushima N, Koizumi M, et al (2014). A case of mixed adenoneuroendocrine carcinoma of the gallbladder arising from an intracystic papillary neoplasm associated with pancreaticobiliary maljunction. Pathol. Int. 64:465-471.

Mondolfi AEP, Slova D, Fan W, et al (2011). Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: A possible stem cell tumor? Pathol Int. 61:608-614.

Qiang JK, Kim WB, Baibergenova A, et al (2016). Risk of Malignancy in Dermatomyositis and Polymyositis. J. Cutaneous Med. Surg. 21(2):131–136. 

Sasaki H, Kohsaka H (2018). Current diagnosis and treatment of polymyositis and dermatomyositis. Modern Rheumatol. DOI: 10.1080/14397595.2018.1467257.

Song W, Chen W, Zhang S, et al (2012). Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy. Diagnostic Pathol. 7:163.

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