Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
February 2016 Issue Vol. 5(2), pp. 067-073
Copyright © 2016 Global Advanced Research Journals

 

Full Length Research Paper

Microwave Ablation versus Radiofrequency Ablation for Hepatocellular Carcinoma: Effectiveness and Prognosis

Mohamed Reyad1, Abd Allah A. El-Sawy2*, Amr M. El-Badry3 and Laila Mahmoud4

1Resident of Internal medicine, Faculty of Medicine,  Tanta University, Egypt.
2Lecturer of Internal Medicine, Hepatogastroenetrology Unit, Faculty of medicine, Tanta University, Egypt.
3Ass.Professor of Radiology Department, Faculty of medicine, Tanta University, Egypt.
4Professor of Internal Medicine, Faculty of medicine, Tanta University, Egypt.

*Corresponding Author E-mail: abdallahelsawy@hotmail.com

Accepted 29 February, 2016

Abstract

The aim of our study was to evaluate the therapeutic efficacy of percutaneous microwave (MW) ablation versus radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) measuring upto5 cm in greatest diameter. This study was performed at hepatogastroenterology unit of internal medicine department at Tanta university hospitals.Patients with conclusive diagnoses of HCC underwent percutaneous MW or RF ablation from January 2013 to December 2013. According to used type of ablation, all patients were divided into two groups. Group I: included 60 patients (with 95 tumors) had undergone MW ablation. Group II: included 70 patients (with 105 tumors) had undergone RF ablation. Complete ablation (CA), partial ablation (PA), local tumor progression (LTP), distant recurrence (DR) and complications were compared between both groups. We found that CA tumors with MW ablation were more than that in RF ablation but without significance in lesions ≤3 cm in diameter (55/60, 91.6% and 65/75, 86.6%) respectively, P=0.7981), however, this difference was significant in lesions 3.1-≤5 cm in diameter (30/35, 85.7% and 10/30, 33.3% respectively, P=0.0388). At same time, RF had PA tumors more than MW but without significance if lesions ≤3 cm in diameter (5/60, 8.3% and 10/75, 13.3% respectively, P=0.5843), however this difference was statically significant in lesions 3.1-≤5 cm in diameter (5/35, 14.2% and 20/30, 66.6% respectively, P=0.0045). During the two years follow-up period for tumors ≤3cm in diameter of both groups, LTP was observed in eight tumors in MW group (8/60,13%) and in sixteen tumors in RF group (16/75,21%) with non-significant difference (P=0.1944), while, for larger tumors 3.1-≤5 cm in diameter LTP was observed in four tumors (4/35,11%) in MW group and in ten tumors (10/30, 33%) in RF group with a significant difference (P=0.0387). Tumor DR was observed in 25 patients (41.6%) of MW group and in 30 patients (42.8%) of RF group with non-significant difference (P=1.0000). Both groups had non-significant difference as regard complications. We can conclude that MW ablation is more effective than RF ablation especially in large HCC.

Keywords:  microwave ablation, radiofrequency ablation, hepatocellular carcinoma

 

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