Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
January 2017 Vol. 6(2), pp. 038-044
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper  

Management of syndromic and familial medullary thyroid carcinoma

Juliana Fernandes de Oliveira1*, Terence Pires de Farias2, Fernando Luiz Dias3, Arli Regina Lopes Moraes1, Juliana Maria de Almeida Vital1, José Gabriel Miranda da Paixão1, Paulo José de Cavalcanti Siebra1, Fernanda Vaisman4 and Ana Carolina Fernandes de Oliveira5 

1Medical residence in Head and Neck Surgery at the National Cancer Institute - INCA, Rio de Janeiro-RJ.
2Researcher of the Brazilian National Cancer Institute – INCA, Rio de Janeiro/RJ.
PhD in Oncology at the Brazilian National Cancer Institute – INCA Rio de Janeiro/RJ.
Assistant Professor of Postgraduate Course in Head and Neck
Surgery of the Pontifical Catholic University of Rio de Janeiro - PUC / RJ.
3Department of Head and Neck Surgery, Brazilian National Cancer Institute, Rio de Janeiro, RJ, Brazil.
Titular Professor of Postgraduate Course in Head and Neck Surgery of the Pontifical Catholic University of Rio de Janeiro - PUC / RJ
Titular of Brazilian Surgeons College.
4PhD in Endocrinology at the Federal University of Rio de Janeiro, UFRJ.
Department of Endocrinology, Brazilian National Cancer Institute, Rio de Janeiro, RJ, Brazil.
5Medical residence in Otorhinolaryngology at the Onofre Lopes University Hospital – HUOL, Natal- RN

*Corresponding Author E-mail: ju.foliveira2@gmail.com; Phone: 05583999023591

Accepted 13 February, 2017

Abstract

Medullary thyroid carcinoma is rare but has a high mortality rate, especially when the source is genetic inheritance. Multiple endocrine neoplasia and familial cancer syndrome have a spectrum of symptoms that determine interventions depending on tumor aggressiveness. A comprehensive data review was prepared using recent articles from PubMed written in English language about hereditary medullary thyroid carcinoma, surgery and follow-up of these patients. The genetic basis of syndromes that involve medullary thyroid carcinoma was confirmed, and guidance was developedfor surgical management with a focus on early diagnosis and treatment.It is essential that we characterize the type of medullary carcinoma for each patient. Early surgery and restricted follow-up maylead to better oncologic outcomes.

Keywords: familial medullary thyroid carcinoma, multiple endocrine neoplasia, syndromic medullary thyroid carcinoma, prophylactic thyroidectomy.

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