Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
March 2016 Issue Vol. 5(3), pp. 074-081
Copyright © 2016 Global Advanced Research Journals

Full Length Research Paper

Cytotoxicity and Bioactive Compounds from Diethyl Ether Extract of lotus halophilus Boiss Et Spruner Growing in Egypt

Amani M. D. El-Mesallamy¹, Shalabia S. Emam², Mohamed H. M. Abed El-Azim^1* and Ibrahim M. Sanad²

¹Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
²Aromatic and Medicinal Plants Department, Desert Research Center, Cairo, Egypt

*Corresponding  Author  E-mail: drmhm1982@gmail.com

Accepted 11 March, 2016

Abstract

In the present study we carried out the GC-MS of lipid diethyl ether extract of the Lotus halophilus boiss et spruner aerial parts to identify its chemical compositions. Fatty acids of the saponifiable fraction revealed the presence of twelve saturated fatty acids and eleven unsaturated fatty acids, in addition a series of (C₄-C₆₉) hydrocarbons and three sterols were identified in the unsaponifiable fraction. Cytotoxic and antioxidant activities were carried out for the ether extract of the plant. The ether extract showed cytotoxic activity against HEPG2 and MCF7, while it was unable to inhibit the growth of HCT; also it showed significant antioxidant activity.   

Keywords: Lotus halophilus, GC-MS, fatty acids, hydrocarbons, sterols, cytotoxic andanti-oxidant activities.