Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
March 2017 Vol. 6(3), pp. 061-066
Copyright © 2017 Global Advanced Research Journals


Full Length Research Paper  

Effect of Quinine therapy on Liver Function Parameters in pregnant women infected with Plasmodium falciparum malaria in Gezira state

Nour Eldaim Elnoman Elbadawi1* and Waleed Ibrahim2

1Clinical Biochemistry, College of Medicine, Shaqra University, Saudi Arabia
2Clinical Immunology, College of Applied Medical Sciences, Shaqra University, Saudi Arabia

*Corresponding Author E-mail:; Mobile Phone: 00966543808051 

Accepted 30 November, 2016


To examine the role of quinine treatment for P. falciparum malaria during pregnancy in alteration of liver function parameters, and correlate the outcome to severity of malaria. The study group included 150 pregnant women with P.falciparum malaria, and fifty healthy pregnant women as controls. Serum levels of aminotransferases; albumin, globulin and total protein; direct and indirect bilirubin as well as total bilirubin were tested in the two groups. As part of the correlation, disease severity was assessed, by dividing patients into a pair of subgroups of severe and uncomplicated malaria. The resulted data statistically analyzed. Aminotransferases as well as total bilirubin, direct bilirubin, and indirect bilirubin were significantly increased in malaria group in comparison with control. Albumin, globulin together with total protein in the study group were lower than the control group. Quinine infusions associated with significant decrease in aminotransferases along with total and indirect bilirubin mean levels. P.falciparum malaria in Sudanese pregnant women could influence liver parameters and quinine partially reverses this influence. Monitoring of liver function parameters assists in avoiding complications during these circumstances.

Keywords: P.falciparum malaria, Pregnancy, Quinine, Liver function parameters


Related Articles

Original Research Article
Baydaa Ali Othman Al–Rawi
Multi- Benefits of CAD/CAM Acrylic Bridge for Primary Incisors
Glo. Adv. Res. J. Med. Med. Sci. October 2017 Vol: 6(10): - [Abstract] [Full Text - PDF] (217 KB)
Sandra N Gonzalez-Diaz, Claudia I Gallego Corella, Gabriela Galindo Rodríguez, Lucia Leal Villarreal, Alfredo Arias Cruz and José Antonio Buenfil López
Asthma and Pregnancy – Comorbid and Coexisting
Glo. Adv. Res. J. Med. Med. Sci. December 2012 Vol: 1(11): - [Abstract] [Full Text - PDF] (1,673 KB)
Original Research Articles
Ibrahim Shah, Shahzeb, Mohammad Hafizullah, Syed Tahir Shah, Mohammad Faheem, Rafiullah
Peripartum cardiomyopathy: risk factors, hospital course and prognosis; experiences at Lady Reading Hospital Peshawar
Glo. Adv. Res. J. Med. Med. Sci. September 2012 Vol: 1(1): - [Abstract] [Full Text - PDF] (206 KB)
T.H. Mostafa, A.M. Abd El-Salaam, Mona E. Farag and M.M. Refaei
Effect of Feeding Treatments on Productive and Reproductive Performance of She-Camels
Glo. Adv. Res. J. Med. Med. Sci. July 2016 Vol: 5(7): - [Abstract] [Full Text - PDF] (352 KB)
Kotingo EL and Allagoa DO
Hepatitis B and C virus Co-Infection in Pregnancy at a Tertiary Hospital, Yenagoa, Bayelsa State, Nigeria
Glo. Adv. Res. J. Med. Med. Sci. February 2018 Vol: 7(2): - [Abstract] [Full Text - PDF] (113 KB)
Ayman Abdellah and Abdelkarim A Abdrabo
Assessment of serum calcium, magnesium, copper and zinc levels in Sudanese pregnant women with pre-eclampsia
Glo. Adv. Res. J. Med. Med. Sci. February 2014 Vol: 3(2): - [Abstract] [Full Text - PDF] (144 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Nour Eldaim Elnoman Elbadawi on Google Scholar
Nour Eldaim Elnoman Elbadawi on Pubmed
Waleed Ibrahim on Google Scholar
Waleed Ibrahim on Pubmed


Viewed 706
Printed 162
Downloaded 369
Powered By iPortal Works