Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
March 2017 Vol. 6(3), pp. 061-066
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper  

Effect of Quinine therapy on Liver Function Parameters in pregnant women infected with Plasmodium falciparum malaria in Gezira state

Nour Eldaim Elnoman Elbadawi1* and Waleed Ibrahim2

1Clinical Biochemistry, College of Medicine, Shaqra University, Saudi Arabia
2Clinical Immunology, College of Applied Medical Sciences, Shaqra University, Saudi Arabia

*Corresponding Author E-mail: noureldaim@hotmail.com; Mobile Phone: 00966543808051 

Accepted 30 November, 2016

Abstract

To examine the role of quinine treatment for P. falciparum malaria during pregnancy in alteration of liver function parameters, and correlate the outcome to severity of malaria. The study group included 150 pregnant women with P.falciparum malaria, and fifty healthy pregnant women as controls. Serum levels of aminotransferases; albumin, globulin and total protein; direct and indirect bilirubin as well as total bilirubin were tested in the two groups. As part of the correlation, disease severity was assessed, by dividing patients into a pair of subgroups of severe and uncomplicated malaria. The resulted data statistically analyzed. Aminotransferases as well as total bilirubin, direct bilirubin, and indirect bilirubin were significantly increased in malaria group in comparison with control. Albumin, globulin together with total protein in the study group were lower than the control group. Quinine infusions associated with significant decrease in aminotransferases along with total and indirect bilirubin mean levels. P.falciparum malaria in Sudanese pregnant women could influence liver parameters and quinine partially reverses this influence. Monitoring of liver function parameters assists in avoiding complications during these circumstances.

Keywords: P.falciparum malaria, Pregnancy, Quinine, Liver function parameters

 

Related Articles


Original Research Article
Bahar Sarıibrahim
Common predictive parameters anticipating pregnancy among poor and normoresponder patients in ICSI
Glo. Adv. Res. J. Med. Med. Sci. July 2017 Vol: 6(7): - [Abstract] [Full Text - PDF] (165 KB)
Case Reports
Nisa Félix and Fátima Palma
Caroli’s disease: management of a rare condition during pregnancy
Glo. Adv. Res. J. Med. Med. Sci. July 2017 Vol: 6(7): - [Abstract] [Full Text - PDF] (969 KB)
Wejdan Mohammad Baabdullah, Doha Malik Bin-Talib, Estabrq Al Hachim, Ayman M Oraif and Hassan SO Abduljabbar
Maternal Morbid Obesity Complications. A Case Report
Glo. Adv. Res. J. Med. Med. Sci. September 2017 Vol: 6(9): - [Abstract] [Full Text - PDF] (747 KB)
Original Research Articles
Baydaa Ali Othman Al–Rawi
Multi- Benefits of CAD/CAM Acrylic Bridge for Primary Incisors
Glo. Adv. Res. J. Med. Med. Sci. October 2017 Vol: 6(10): - [Abstract] [Full Text - PDF] (217 KB)
Makatsariya AD, Perederyaeva EB, Pshenichnikova TB, Bitsadze VO, Andreeva MD and Udovychenko MA
Pathogenetic substantiation of the use of low molecular weight heparin in the prevention of recurrent pregnancy complications and reproductive losses in women with metabolic syndrome
Glo. Adv. Res. J. Med. Med. Sci. March 2017 Vol: 6(3): - [Abstract] [Full Text - PDF] (371 KB)
Ayman Abdellah and Abdelkarim A Abdrabo
Assessment of serum calcium, magnesium, copper and zinc levels in Sudanese pregnant women with pre-eclampsia
Glo. Adv. Res. J. Med. Med. Sci. February 2014 Vol: 3(2): - [Abstract] [Full Text - PDF] (144 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Nour Eldaim Elnoman Elbadawi on Google Scholar
Nour Eldaim Elnoman Elbadawi on Pubmed
Waleed Ibrahim on Google Scholar
Waleed Ibrahim on Pubmed

Statistics

Viewed 515
Printed 137
Downloaded 289
Powered By iPortal Works