Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
March 2017 Vol. 6(3), pp. 061-066
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper  

Effect of Quinine therapy on Liver Function Parameters in pregnant women infected with Plasmodium falciparum malaria in Gezira state

Nour Eldaim Elnoman Elbadawi1* and Waleed Ibrahim2

1Clinical Biochemistry, College of Medicine, Shaqra University, Saudi Arabia
2Clinical Immunology, College of Applied Medical Sciences, Shaqra University, Saudi Arabia

*Corresponding Author E-mail: noureldaim@hotmail.com; Mobile Phone: 00966543808051 

Accepted 30 November, 2016

Abstract

To examine the role of quinine treatment for P. falciparum malaria during pregnancy in alteration of liver function parameters, and correlate the outcome to severity of malaria. The study group included 150 pregnant women with P.falciparum malaria, and fifty healthy pregnant women as controls. Serum levels of aminotransferases; albumin, globulin and total protein; direct and indirect bilirubin as well as total bilirubin were tested in the two groups. As part of the correlation, disease severity was assessed, by dividing patients into a pair of subgroups of severe and uncomplicated malaria. The resulted data statistically analyzed. Aminotransferases as well as total bilirubin, direct bilirubin, and indirect bilirubin were significantly increased in malaria group in comparison with control. Albumin, globulin together with total protein in the study group were lower than the control group. Quinine infusions associated with significant decrease in aminotransferases along with total and indirect bilirubin mean levels. P.falciparum malaria in Sudanese pregnant women could influence liver parameters and quinine partially reverses this influence. Monitoring of liver function parameters assists in avoiding complications during these circumstances.

Keywords: P.falciparum malaria, Pregnancy, Quinine, Liver function parameters

 

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