Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
March 2017 Vol. 6(3), pp. 053-060
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper  

Pathogenetic substantiation of the use of low molecular weight heparin in the prevention of recurrent pregnancy complications and reproductive losses in women with metabolic syndrome

Makatsariya A.D.1*, Perederyaeva E.B.4, Pshenichnikova T.B.5, Bitsadze V.O2, Andreeva M.D.3 and Udovychenko M.A.6.

1MD, Corresponding member of the Russia Academy of Science, Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medical and Preventive, FSBEI HE I.M. Sechenov First MSMU MOH Russia. Address: ul. Trubetskaya, 8-2, Russia, 119048.
2MD, Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive, FSBEI HE I.M. Sechenov First MSMU MOH Russia. Address: ul. Trubetskaya, 8-2, Russia, 119048.
3Professor of Kuban State Medical University, the Chair of Obstetrics Gynecology and Perinatology. Address: Krasnodar, ul. Sedina 4, Russia, 350000.
4PhD of medical sciences, Senior Researcher. First Moscow State Medical University of the Ministry of Health Russia Federation. Address: ul. Trubetskaya, 8-2, Russia, 119048.
5PhD of medical sciences, Senior Researcher. First Moscow State Medical University of the Ministry of Health Russia Federation. Address: ul. Trubetskaya, 8-2, Russia, 119048.
6M.D. FSBEI HE I.M. Sechenov First MSMU MOH Russia. Address: ul. Trubetskaya, 8-2, Russia, 119048.

*Corresponding  Author  E-mail: gemostasis@mail.ru Tel.: +74957885840.

Accepted 20 March, 2017

Abstract

Metabolic syndrome is associated with at higher risk of developing various obstetric complications. The endotheliopathy, proinflammatory and prothrombotic status may play an important role in impaired invasion cytotrophoblast and impaired placental development that leads to fetal loss, pre-eclampsia and other obstetric complications in women with metabolic syndrome. It is necessary to conduct screening for latent thrombophilia (acquired and genetic forms), markers of thrombophilia, and perform mandatory antithrombotic therapy in patients with metabolic syndrome. This will optimize the principles of management of women with the metabolic syndrome in obstetric practice.

Keywords: Metabolic syndrome, obstetric complications, endotheliopathy, proinflammatory and prothrombotic status, antithrombotic therapy.

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