Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
April 2015 Vol. 4(4), pp. 183-189
Copyright © 2015 Global Advanced Research Journals


Full Length Research Paper

Possıble protectıve effect of applyıng vıtamın E to the rats havıng been exposed to cıgarette smoke: an anımal study

Muzeyyen Duran1*, Aydin Kosus2, Gokalp Oner1, Nermin Kosus2, Gulce Naz Sarac3 and Nilgun Turhan1

1Mugla Sitki Kocman University Faculty of Medicine , Department of Obstetrics and Gynecology, Mugla, Turkey
2Turgut Ozal University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey
3Gazi University Faculty of Medicine, Department of Histology and Embryology, Ankara, Turkey

*Corresponding Author E-mail:; Phone: 0905438090882

Accepted 04 April, 2015


To show the possible healing effects in ovarian apoptosis that deteriorates due to smoking  by  giving vitamin supplement to the rats having empirically been exposed  to cigarette smoke. Swiss albino rats that are 12–14 weeks old  and  25.19 ± 4.34 gr were chosen for  the experiment. The experimental  groups were formed by dividing female rates into groups of six in different cages. Experimental groups: Group A: Control female rats (n=6) , Group B: Female rats that were exposed to cigarette  smoke (n=6), Group C: Female rats  that were given antioxidant along with cigarette smoke (n=6). Midluteal phase was determined by taking a smear from female rats. The rats were euthanized by applying overdose alphamine- alphasine. Ovarian tissue taken from the rats was evaluated under a light  microscope by means of immunohistochemical method. Not any significant difference was observed in statistical terms when ovarian  follicle numbers were compared (p< 0.05). While the number of the cells stained by caspase -3 (immunoreactive cells) were on the increase, though not important in statistical terms, in the group  subjected  to cigarette smoke (Group B), there wasn’t any crucial difference between the group applied vitamin  E (Group C) and control group in statistical terms. (p< 0.05). An increase, though not important, was detected in ovarian apoptosis with smoking. Similar findings were identified between  the control group and the group given vitamin E. Therefore, it was concluded that vitamin E supplement has a curative effect on the negative effects of the cigarette.

Keywords: ovarian apoptosis, cigarette, vitamin E


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