Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
April 2015 Vol. 4(4), pp. 183-189
Copyright © 2015 Global Advanced Research Journals
Full Length Research Paper
Possıble protectıve effect of applyıng vıtamın E to the rats havıng been exposed to cıgarette smoke: an anımal study
Muzeyyen Duran1*, Aydin Kosus2, Gokalp Oner1, Nermin Kosus2, Gulce Naz Sarac3 and Nilgun Turhan1
1Mugla Sitki Kocman University Faculty of Medicine , Department of Obstetrics and Gynecology, Mugla, Turkey
2Turgut Ozal University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey
3Gazi University Faculty of Medicine, Department of Histology and Embryology, Ankara, Turkey
*Corresponding Author E-mail: drmuzeyyenduran@gmail.com; Phone: 0905438090882
Accepted 04 April, 2015
Abstract
To show the possible healing effects in ovarian apoptosis that deteriorates due to smoking by giving vitamin supplement to the rats having empirically been exposed to cigarette smoke. Swiss albino rats that are 12–14 weeks old and 25.19 ± 4.34 gr were chosen for the experiment. The experimental groups were formed by dividing female rates into groups of six in different cages. Experimental groups: Group A: Control female rats (n=6) , Group B: Female rats that were exposed to cigarette smoke (n=6), Group C: Female rats that were given antioxidant along with cigarette smoke (n=6). Midluteal phase was determined by taking a smear from female rats. The rats were euthanized by applying overdose alphamine- alphasine. Ovarian tissue taken from the rats was evaluated under a light microscope by means of immunohistochemical method. Not any significant difference was observed in statistical terms when ovarian follicle numbers were compared (p< 0.05). While the number of the cells stained by caspase -3 (immunoreactive cells) were on the increase, though not important in statistical terms, in the group subjected to cigarette smoke (Group B), there wasn’t any crucial difference between the group applied vitamin E (Group C) and control group in statistical terms. (p< 0.05). An increase, though not important, was detected in ovarian apoptosis with smoking. Similar findings were identified between the control group and the group given vitamin E. Therefore, it was concluded that vitamin E supplement has a curative effect on the negative effects of the cigarette.
Keywords: ovarian apoptosis, cigarette, vitamin E
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