Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
April 2015 Vol. 4(4), pp. 168-175
Copyright © 2015 Global Advanced Research Journals


Full Length Research Paper

Reversibility of Diabetic Cardiac Changes in Albino Rats by Insulin Glargine Treatment

Nadia Mahmoud Mohamed Al Rouby1* and Raeesa Abdel Tawab Mohamed2

1Anatomy and Histology department, Dubai Medical College, UAE
2Anatomy department, Collage of Medicine, King Saud University, KSA

*Corresponding  Author  E-mail:; Mobile number: 00971-503617646

Accepted 11 December, 2014


Diabetes mellitus (DM), a condition of chronic hyperglycemia, represents one of the greatest concerns to modern global health. DM is a well-recognized cause of cardiomyopathy and left ventricular dysfunction. It is accompanied by impaired antioxidant defenses including nitric oxide (NO). Aim of work was to; (1) evaluate the microscopic changes in the heart of diabetic rats, (2) study the possible reversibility of these diabetic-induced cardiac changes by insulin glargine. Forty male albino rats were divided into; control group, non treated diabetic group and diabetic group treated with insulin glargine. DM was induced by intra-peritoneal alloxan injection. The experiment continued for six weeks. Heart tissues were prepared and stained with H&E, PAS and immunostained against e NOS. Heart tissue of diabetic rats revealed myocardial degeneration, disarray of myocardial fibers, mononuclear cellular infiltration; decreased e NOS immunoexpression in cardiomyocytes as well as endothelial cells and smooth muscles of cardiac blood vessels. Administration of insulin glargine improved these diabetic changes to great extent and increased e NOS immunoexpression. Insulin has to be given as early as possible for insulin dependent diabetics to control diabetic cardiac complications. NO is important for cardiac functions. Insulin has a role in cardiac e NOS expression.

Keywords: Diabetes, rats, heart, insulin glargine, e NOS

Related Articles

Original Research Articles
Achukwi Mbunkah Daniel, Ngam Sali, Maxime Madder, Mfopit Mouliom Youssouf, Nain Caroline Waingeh, Manchang Tanyi Kingsley, Ndzingu Awa Daniel, Dirk Geysen
Molecular detection of concurrent infections of Anaplasma sp Omatjenne, Theileria mutans, Babesia bigemina and Anaplasma marginale in calves and yearlings in a tick endemic Guinea savannah ecosystem in Cameroon
Glo. Adv. Res. J. Med. Med. Sci. August 2020 Vol: 9(4): - [Abstract] [Full Text - PDF] (834 KB)
Hind A. A. Al-Zahrani
Solid state fermentation using agro industrial residues for alpha amylase production by an actinomycete isolate from red sea soil
Glo. Adv. Res. J. Med. Med. Sci. June 2018 Vol: 7(4): - [Abstract] [Full Text - PDF] (458 KB)
Hana M Gashlan and Asma B Al-Beladi
Effects of Clove Oil on Liver and Antioxidant Status of Streptozotocin-Induced Diabetic Rats
Glo. Adv. Res. J. Med. Med. Sci. June 2017 Vol: 6(6): - [Abstract] [Full Text - PDF] (853 KB)
Mekkawy, IAA; Ahmed S. A. Harabawy; U. M. Mahmoud
Intra- and inter-specific variations in some isoenzymes and in eye-lens nucleus and muscle proteins of three Lethrinus species from the Red Sea at Hurghada, Egypt.
Glo. Adv. Res. J. Med. Med. Sci. February 2016 Vol: 5(2): - [Abstract] [Full Text - PDF] (1,391 KB)
Tugbobo OS, Abegunde SM and Idowu KS
Protection by Dialium indium (Fruit) against Pb2+-Induced Microcytic Anemia and Chromosome Aberration in Albino Rats In Vivo
Glo. Adv. Res. J. Med. Med. Sci. October 2018 Vol: 7(8): - [Abstract] [Full Text - PDF] (85 KB)
Ragaa Hosny Mohamad1, Azza Mahmoud Farahat, Mohamad Gamil Abdel Moneim, Amal Mohamad El Bastawesy, Safaa Ahmed Salem
Therapeutic Value Of Camel Milk Supplemented With Echinacea Consumption By Albino Rat
Glo. Adv. Res. J. Med. Med. Sci. March 2015 Vol: 4(3): - [Abstract] [Full Text - PDF] (1,317 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Nadia Mahmoud Mohamed Al Rouby on Google Scholar
Nadia Mahmoud Mohamed Al Rouby on Pubmed
Raeesa Abdel Tawab Mohamed on Google Scholar
Raeesa Abdel Tawab Mohamed on Pubmed


Viewed 2254
Printed 359
Downloaded 1035
Powered By iPortal Works