Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
April 2016 Issue Vol. 5(4), pp. 096-102
Copyright © 2016 Global Advanced Research Journals

Full Length Research Paper

Evaluation of serum cortisol, growth and thyroid hormones and its relation with lipolysis in non-diabetic obese and diabetic obese subjects attending Sohag Governorate, Egypt

Ali Taha A. Hassan¹, Hossam El-Din M. Omar², Nagwa M. Elsawi³* and Amira M. Ahmed³

¹Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag 82524, Egypt
²Zoology Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
³Department of Chemistry, Faculty of Sience, Sohage University, Sohage 82524, Egypt

*Corresponding Author E-mail: elsawinagwa@yahoo.com

Accepted 11 April, 2016 

Abstract

The study aim to estimate the level of some hormones and free fatty acids which have a role in metabolic processes and its relation to obesity and diabetes 2 type. Cortisol, growth and thyroid hormones were determined by ELISA in serum of 85 subjectes including 30 controls, 31 non-diabetic obese and 24 obese diabetic. Obesity is described according to BMI. Blood pressure and glucose level were measured for all participants.  Free fatty acids (FFAs) analysis was performed by gas chromatography technique. Hormonal assays were performed by ELISA methods Results: Blood levels of cortisol in non-diabetic obese subjects was non-significantly  decreased compared to control group, while in obese diabetic group increased significantly compared to non-diabetic obese subjects. Growth hormone in both non-diabetic obese and obese diabetic groups was decreased compared to controls. Thyroid hormones T₃ and T₄ showed a non-significant decrease in non-diabetic obese subjects compared to control group, however, increased significantly in obese diabetic group compared to non-diabetic obese group. Blood FFAs showed various changes in unsaturated and saturated among the three groups. In conclusion, the present study found that changes in the levels of cortisol, growth hormone and thyroid hormones were correlated with BMI and the level of FFAs in serum.

Keywords: obesity, diabetes type 2, cortisol, growth hormone, thyroid hormones and FFAs.