Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
May 2018, Vol. 7(5), pp. 105-110
Copyright © 2018 Global Advanced Research Journals

 

Full Length Research Article

Comparative analysis of antibacterial potency of six fluoroquinolone antibiotics commonly prescribed in Uyo, Akwa Ibom State, Nigeria in the treatment of Salmonela typhi infections

Akeem Agboke* and Ekanem Etim

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo Nigeria.

*Corresponding Author E-mail: ayoagboke@yahoo.com

Accepted 11 August, 2017 

Abstract

Comparative analysis of antimicrobial potency of six common fluoroquinolone antibiotics was done. They were chosen based on their availability and affordability which includes: Ciprofloxacin, Pefloxacin, Levofloxacin, Norfloxacin, Ofloxacin and Sparfloxacin, in the treatment of Salmonela typhi infections in Uyo, Akwa Ibom state of Nigeria. Sensitivity test of different concentrations of the six fluoroquinolones were carried out on the test organism (Salmonella tyhpi) using agar well diffusion method. The Minimum Inhibitory Concentration (MIC) which indicates the strength of each of the fluoroquinolones used on the test organism were determined. The result obtained showed that Pefloxacin had the highest antibacterial strength against the test organism with MIC of 0.0003, followed by Norfloxacin (0.0006), Ciprofloxacin (0.0010), Levofloxacin (0.0016), Ofloxacin (0.0042) and Sparfloxacin having the lowest with MIC of 0.0398. The analysis of variance (ANOVA) showed a significant difference (P<0.05) among the MIC of the six fluoroquinolones used. Post Hoc Test result indicates a significant of 1.000 among the MIC of the six fluoroquinolones.

Keywords: Antimicrobial, Antibiotics, fluoroquinolones and Salmonela typhi

 

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