Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
June 2016 Issue Vol. 5(6), pp. 194-198
Copyright © 2016 Global Advanced Research Journals


Full Length Research Paper

Vitamin D deficiency and recurrent pregnancy loss in Iranian women

Neda Ghaedi1, Sedighe Forouhari2*, Jaleh Zolghadri2, Mehrab Sayadi3, Azar Nematollahi4 and Khadijeh Khademi5

1(P.B.U.H) School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
2Infertility Research Center, Shiraz University of Medical Sciences, Shiraz-Iran.
3Student, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
4Community Based Psychiatric Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
5Nursing and Midwifery School, Tehran University of Medical Sciences, Tehran, Iran.

*Corresponding Author E-mail:

Accepted 20 June, 2016


Vitamin D deficiency is a common problem worldwide. Recurrent Pregnancy Loss (RPL) is considered as a controversial subject in reproductive medicine and is unexplained in half of the cases. the immunological factors mayplay a role in failure of pregnancyin women with RPL. The role of this vitamin D has also been proved in the immune system. The present study aimed to investigate vitamin D deficiency with some factors in the women with the history of RPL and those with the history of Sporadic Pregnancy Loss (SPL). This cross-sectional study was conducted on 120 pregnant women with gestational age below 20 weeks (60 women with RPL and 60 women with SPL) who had referred to the clinics affiliated to Shiraz University of Medical Sciences within the past 6 months. The participants’ serum vitamin D levels were measured. Low vitamin D levels (<8 ng/ml) were observed in 20 out of the 60 women with RPL (33.3%) versus 9 out of the 60 ones with SPL (15%) that revealed a association between the women with RPL and those with SPL regarding vitamin D deficiency (P=0.038).also the median serum level of vitamin D was 9.20 ng/ml in the women with four or more abortions, 10.85 ng/ml in those with three abortions, and11.50 ng/ml in the women with two abortions. It seems that vitamin D deficiency plays a role in miscarriage in the women with RPL by defect of the immune inflammatory response. Thus, routine request of 25-hydroxy vitamin D test and prescription of vitamin D supplements are important in these women.

Keywords: Recurrent pregnancy loss, Vitamin D, Immune inflammatory response



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