Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
June 2017 Vol. 6(6), pp. 111-115
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper 

Comparison of the cost-effectiveness of Propofol intravenous anesthesia and Isoflurane inhalation anesthesia: a randomized clinical Trial

Javad Nourian1, Fatemeh Mehravar2 and Mohammad Bagher Sohrabi3* 

1Department of Anaesthesiology, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.
2MSc of Epidemiology, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.
3General Practitioner, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

*Corresponding Author E-mail: mb.sohrabi@yahoo.com;  Tel: +982332395054; Fax: +982332394800

Accepted 19 June, 2017

Abstract

In the recent years, managed care plans have been presented and physicians and health care centers focused on cost-effectiveness of medical procedures. The purpose of this study was comparison of the cost-effectiveness of intravenous Propofol anesthesia versus inhalational Isoflurane anesthesia for maintenance of anesthesia. In this randomized, single-blind, parallel clinical trial, 104 eligible consecutive surgical patients were selected in Imam Hossein hospital of Shahroud and randomly placed into two groups after justification and obtaining informed consent. In intervention group Anesthesia continued with Propofol and Fentanyl and in control group it continued with Isoflurane and Fentanyl. Anesthesia depth monitoring was performed in all patients and Bispectral Index (BIS) was kept between 45 and 60. The outcome measures include systolic blood pressure, heart rate, sweating and pupil size during anesthesia also recovery complications and recovery duration. Price of the used anesthetic for each patient was calculated. In Propofol group were lower nausea and vomiting, after operation and also the average recovery time was significantly lower in Propofol group (p = 0.0001). Other variables such as the cost of anesthesia had not significant difference and were similar in both groups. Induction with Propofol with Bispectral Index control for maintenance of anesthesia is more effective than Isoflurane. Propofol causes less postoperative nausea and vomiting, shorter recovery time, no environmental pollution and it does not impose additional cost to the patient and the hospital.

Keywords: Anesthesia, Isoflurane, Propofol, Cost-effectiveness

 

References

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