Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
June 2017 Vol. 6(6), pp. 103-110
Copyright © 2017 Global Advanced Research Journals


Full Length Research Paper 

Effects of Clove Oil on Liver and Antioxidant Status of Streptozotocin-Induced Diabetic Rats

Hana M. Gashlan* and Asma B. Al-Beladi

Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

*Corresponding Author E-mail:,

Accepted 19 June, 2017


This study was design To evaluate the hepatoprotective and antioxidant effect of low and high doses of clove oil on diabetic rats. Forty female albino rats were equally divided into four groups. The first group served as control (G1). The other 3 groups were intraperitoneal injected with 45 mg/kg body weight of streptozotocin (STZ) to induce diabetes. One diabetic group (G2) kept untreated and served as positive control. The other diabetic groups (G3 and G4) were treated with 300 mg/kg and 600 mg/kg of clove oil respectively. Results revealed that the STZ-induced diabetic group exhibited high significant increase in the activities of the liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) as well as  reduction in the activities of catalase, superoxide dismutase and glutathione reductase compared to the control group. Diabetic groups treated with different doses of clove oil showed a decrease in the activities of liver enzymes in and increase in antioxidant enzymes activities compared to untreated diabetic group. Histopathological examination of liver tissues of diabetic rats indicated sever changes. However, their changes were overcome by clove oil treatment and the majority of the cells tend to be normal. Clove oil supplementation may act as antioxidant agents and could be an excellent adjuvant support in therapy of diabetes mellitus and its complications.

Keywords: Diabetes, albino rats, clove oil, streptozotocin, diabetes mellitus, liver enzymes, antioxidant and histopathology.



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