Global Advanced Research Journal of Medicine and Medical Sciences
July 2012 Vol. 1(6), pp. 154-162
Copyright © 2012 Global Advanced Research Journals

 

Full Length Research Paper

Age at cancer diagnosis in Malawi

Humphrey Misiri1,2 * and  Abdi Edriss3

1Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
2Department of Community Health, College of Medicine, Blantyre, Malawi.
3Bunda College, University of  Malawi, Lilongwe, Malawi.

*Corresponding author E-mail: hmisiri@gmail.com, humphrey.misiri@medisin.uio.no ; Tel/Cell: +265-888-342-864: Fax: +265-1874-700

Accepted 28 June, 2012

Abstract

Cancer which is one of the leading causes of death worldwide is emerging as a serious public health problem in Malawi due to the AIDS pandemic. Research has shown that HIV causes the syndrome of premature aging and accelerates carcinogenesis. The objective of this study was to describe age at cancer diagnosis and to fit the age distribution of childhood and adult cancer diagnosis in Malawi. We therefore fitted the normal, gamma, lognormal and inverse Gaussian probability distributions to the data for the 1996–2005 period from the Malawi National Cancer Registry and selected the model of best fit using the Akaike Information Criterion. Additionally, a finite mixture distribution of lognormals was also fitted to the data. According to the analysis for this study, the median ages at diagnosis are at most 42 years for AIDS-defining cancers and at least 46 years for non-AIDS defining cancers. Furthermore, the ages at childhood and adult cancer diagnosis follow lognormal distributions and the distribution of age at cancer diagnosis (all cancers) is a finite mixture distribution of lognormals with estimated mixing proportions equal to 0.071 and 0.929. The estimated means of the mixture distribution are 5.1 and 45.1 years and the corresponding estimated standard deviations are 1.211 and 2.842 years. This analysis suggests that age at cancer diagnosis in Malawi is relatively low and has a bimodal distribution. Therefore, to achieve maximum impact, cancer prevention and control activities should target the 15-50 year age range.

Keywords: cancer, diagnosis, AIC, finite mixture.

Related Articles


Review
Mohammed Helmy Faris Shalayel, Ahmed Morad Asaad, Jobran Miree Alqahtani, Ietimad AM Ayed, Mohamed Ansar Qureshi, Moawia A Elbadri
Biochemical and virological aspects beyond Ebola virus - Prospects for medications and immunization.
Glo. Adv. Res. J. Med. Med. Sci. December 2014 Vol: 3(10): - [Abstract] [Full Text - PDF] (526 KB)
Original Research Articles
Mohammed HF Shalayel, Amin AA Elbadawi, Ietimad AM Ayed, Khalid O Abosalif, Gadallah Modawe, Ihab Hamed Nourein, Nuha G Ahmed and Sayda H El Safi
Sensitivity of aqueous and freeze-dried DAT (AQ-DAT and FD-DAT) in diagnosis of visceral leishmaniasis in Sudan- Possibility of adapting the DAT (aqueous antigen) as a rapid test by using blood spot on filter paper
Glo. Adv. Res. J. Med. Med. Sci. February 2015 Vol: 4(2): - [Abstract] [Full Text - PDF] (292 KB)
Juliana Fernandes de Oliveira, Terence Pires de Farias, Fernando Luiz Dias, Arli Regina Lopes Moraes, Juliana Maria de Almeida Vital, José Gabriel Miranda da Paixão, Paulo José de Cavalcanti Siebra, Fernanda Vaisman and Ana Carolina Fernandes de Oliveira
Management of syndromic and familial medullary thyroid carcinoma
Glo. Adv. Res. J. Med. Med. Sci. February 2017 Vol: 6(2): - [Abstract] [Full Text - PDF] (128 KB)
Sara Khalifa, Mohamed Yousef, Ikhlas Abdelaziz, Jumaa Tamboul, Awadia Gareeballah and Ala Mohammed Abd Elgyoum
Characterization of Cardiac Diseases Using Multi-Slice Spiral Computed Tomography
Glo. Adv. Res. J. Med. Med. Sci. December 2017 Vol: 6(12): - [Abstract] [Full Text - PDF] (152 KB)
Ragaa Hosny Mohamad1, Azza Mahmoud Farahat, Mohamad Gamil Abdel Moneim, Amal Mohamad El Bastawesy, Safaa Ahmed Salem
Therapeutic Value Of Camel Milk Supplemented With Echinacea Consumption By Albino Rat
Glo. Adv. Res. J. Med. Med. Sci. March 2015 Vol: 4(3): - [Abstract] [Full Text - PDF] (1,317 KB)
Saghatelyan AK, Revazyan RH, Ajabyan NA
Early Diagnosis of Ecosystem Pollution and Its Prognosis.
Glo. Adv. Res. J. Med. Med. Sci. July 2013 Vol: 2(7): - [Abstract] [Full Text - PDF] (235 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Humphrey Misiri on Google Scholar
Humphrey Misiri on Pubmed
Abdi Edriss on Google Scholar
Abdi Edriss on Pubmed

Statistics

Viewed 1012
Printed 282
Downloaded 432
Powered By iPortal Works