Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
July 2014 Vol. 3(7), pp. 152-158
Copyright © 2014 Global Advanced Research Journals


Case Report

Treatment of oral Kaposi sarcoma by sirolimus in renal transplanted children: case report and literature review

Kadriye Ozdemir¹*, Nida Dincel¹, Ebru Yılmaz¹,  Banu Yaman², Gozde Gozuoglu1 and Sevgi Mir¹

¹Ege University Faculty of Medicine, Department of Pediatric Nephrology, İzmir, Turkey
²Ege University Faculty of Medicine, Department of Pathology, İzmir, Turkey

*Corresponding Author E-mail:;  Phone: +905056822717

Accepted 07 July, 2014


Kaposi Sarcoma is one of the most common neoplasia seen in patients after kidney transplantation. The mean occurrence time for malignant tumors after renal transplantation was reported as 61 months whereas for Kaposi’s sarcoma it was written as 20 months. The etiopathogenesis is poorly understood, mostly dependent on human herpesvirus type 8 (HHV-8) infection. In this study, we reported the occurrence of oral Kaposi’s sarcoma in a pediatric renal transplant patient on the 10th months after transplantation and complete regression of lesions with well functioning graft, via sirolimus therapy. A 13-year-old boy received a renal graft from a living unrelated donor. On the 10th months of transplantation, he admitted to hospital with a flat purple lesion of 17x11x3 mm in diameter on his left gum, presenting for 3 weeks. He also had a violaceous macular lesion on anterior one-third of the leg. The patient's HIV antibody repeated twice was negative. The biopsy result of the lesion revealed the diagnosis of KS. Diagnosis of oral Kaposi sarcoma was made. The graft was functioning well and there was no systemic involvement. Cyclosporine A was stopped and sirolimus started. He has been on our follow up for a year without any recurrence and with well functioning graft. In the presented case, we wanted to emphasize importance of the switch to sirolimus in the treatment of Kaposi Sarcoma seen in the early post transplant period.

Keywords: Kaposi Sarcoma, kidney transplantation, sirolimus


Related Articles

Original Research Articles
Humphrey Misiri, Charles Dzamalala, Abdi Edriss, D Max Parkin and Freddie Bray
Cancer incidence in Malawi: Time trends in Blantyre 1996-2005 and predictions up to 2015
Glo. Adv. Res. J. Med. Med. Sci. July 2012 Vol: 1(6): - [Abstract] [Full Text - PDF] (364 KB)
Enow Orock GE, Verla VS, Ashuntantang GE, Ndom P, and Doh AS
Kaposi Sarcoma: A review of 387 cases seen in Yaounde, Cameroon
Glo. Adv. Res. J. Med. Med. Sci. September 2013 Vol: 2(9): - [Abstract] [Full Text - PDF] (517 KB)
Valéria Baccarin Ianiski, Ligia Beatriz Bento Franz, Juliana Schneider, Matias Nunes Frizzo and Eliane Roseli Winkelmann
Oxidative stress and power in patients post - kidney transplantation: a cross study
Glo. Adv. Res. J. Med. Med. Sci. October 2015 Vol: 4(10): - [Abstract] [Full Text - PDF] (157 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Kadriye Ozdemir on Google Scholar
Kadriye Ozdemir on Pubmed
Nida Dincel on Google Scholar
Nida Dincel on Pubmed
Ebru Yılmaz on Google Scholar
Ebru Yılmaz on Pubmed
Banu Yaman on Google Scholar
Banu Yaman on Pubmed
Gozde Gozuoglu on Google Scholar
Gozde Gozuoglu on Pubmed
Sevgi Mir on Google Scholar
Sevgi Mir on Pubmed


Viewed 1179
Printed 343
Downloaded 962
Powered By iPortal Works