Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
July 2017 Vol. 6(7), pp. 162-167
Copyright © 2017 Global Advanced Research Journals

 

Full Length Research Paper 

Common predictive parameters anticipating pregnancy among poor and normoresponder patients in ICSI

Bahar Sarıibrahim

Zeynep Kamil Obstetrics and Gynecology Research and Education Hospital IVF Unit, Istanbul/Turkey

E-mail: baharsariibrahim@hotmail.com; Tel:05058942924; Fax:02622334641

Accepted 19 July, 2017

Abstract

Multiple parameters are being considered in the field of IVF/ICSI success. It is difficult to estimate patient's response to ovarian stimulation in poor responder IVF/ICSI patient group. The objective of this study is to find the common predictive parameters anticipating positive pregnancy results among poor responder and normoresponder  IVF/ICSI patients. It was a retrospective study, examining medical records of 96 poor responder, 117 normoresponder patients between the ages 23-39 years who performed ICSI between June 2013-March 2015 at Zeynep Kamil Obstetrics and Gynecology Research and Education Hospital IVF Unit. Study (poor responder) and control (normoresponder) groups were evaluated in regard of positive pregnancy results. According to the results of AUCs and ROC curves five significant variables; the number of retrieved oocytes, the number of M2 oocytes, the number of fertilized oocytes, the day of embryo transfer and normoresponder group could be considered as diagnostic markers in the study and control groups and clinically these markers might be accepted as predictive parameters. The number of retrieved oocytes, the number of M2 oocytes, the number of fertilized oocytes, the day of embryo transfer and being in normoresponder group could be accepted  as predictive parameters anticipating positive pregnancy results among poor and normoresponder IVF patients. These parameters can also help couples deciding on subsequent IVF treatments or counseling for donor egg selection option.

Keywords: Poor responder, ART outcome predictor

 

References

Beth McAvey, Athena Zapantis MS, Sangita BS, Jindal K, Harry J Lieman, Alex J Polotsky (2011). How many eggs are needed to produce an assisted reproductive technology baby: is more always better? Fertil.  Steril.  96:332-335

Fauser BC, Diedrich K, Devroey P (2008). Evian Annual Reproduction Workshop Group 2007(2008)Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation. Hum. Reprod. 14(1):1-14

Godwin I Meniru, Ian L Craft (1997). Utilization of retrieved oocytes as an index of the efficiency of superovulation strategies for in-vitro fertilization treatment. Hum. Reprod. 12:2129-2132

John J Zhang, Mingxue Yang, Zaher Merhi (2016). Reproductive potential of mature oocytes after conventional ovarian hyperstimulation for in vitro fertilization. IJG. 08584;1-4

KablyAmbe A, Estevez Gonzalez S, Carballo Mondragon E, Duran Monterrosas L (2008). Comparative analysis of pregnancy rate/captured oocytes in an in vitro fertilization program. Ginecol. Obstet. Mex. 76:256-260

Mangalraj AM, Muthukumar K, Aleyamma T, Kamath MS, George K (2009). Blastocyst stage transfer vs cleavage stage embryo transfer. J. Hum. Reprod. Sci. 2:23-26

Molina Hita Ma. del M, Lobo Martinez S, Gonzalez Varea, Montejo Gadea JM, Garijo Lopez E, Cuadrado Mangas C (2008). Correlation between the number of oocytes and the pregnancy rate in IVF-ICSI cycles. Revista Iberoamericana de Fertilidad y Reproduccion Humana 25:153-159

Panagiotis Drakopoulos, Christophe Blockeel, Dominic Stoop, Michel Camus, Michel de Vos, Herman Tournaye, Nikolaos P Polyzos (2016). Conventional ovarian stimulation and single embryo transfer for IVF/ICSI.How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum. Reprod. 31:370-376

Prabhleen Kaur, Swarankar ML, Manju Maheshwari, Veena Acharya (2014). A comparative study between cleavage stage embryo transfer at day 3 and blastocyst stage transfer at day 5 in in-vitro fertilization/intra-cytoplasmic sperm injection on clinical pregnancy rates. J. Hum. Reprod. Sci.  7:194-197

Przemyslaw Ciepiela, Pawel Kuc, Agnieszka Kuczynska, Anna Kazienko, Rafal Kurzawa, Waldemar Kuczynski (2015). Reproductive outcomes of intracytoplasmic sperm injection (ICSI) in good-prognosis patients who electively decided to limit the number of oocytes used for microinjection: a two-center comparative study. Ginekol. Pol. 86:748-752

Sesh Kamal Sunkara, Vivian Rittenberg, Nick Raine-Fenning, Siladitya Bhattacharya, javier Zamora, Coomarasamy (2011). Association between the number of eggs and live birth in IVF treatment:an analysis of 400135 treatment cycles. Hum. Reprod. 26:1768-1774

Van der Auwera I, Debrock S, Spiessens C, Afschrift H, Bakellants E, Meuleman C, et al (2002). A prospective randomized study: Day 2 versus day 5 embryo transfer. Hum. Reprod. 17:1507-1512

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Bahar Sarıibrahim on Google Scholar
Bahar Sarıibrahim on Pubmed

Statistics

Viewed 186
Printed 59
Downloaded 160
Powered By iPortal Works