Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
July 2018, Vol. 7(6), pp. 125-126
Copyright © 2018 Global Advanced Research Journals


Short Communication

Involuntary seminal emission during defecation induced by Fluoxetine

Howard O. Clark, Jr.

Colibi Ecological Consulting, LLC, 9493 N Fort Washington Road, Suite 108, Fresno, CA 93730-0637

E- mail:

Accepted 26 July, 2018


Fluoxetine, N-methyl-3-phenyl-3-[4-(trifluoromethyl) phenoxy]-propan-1-amine hydrochloride, is in a class of drugs called selective serotonin reuptake inhibitors (SSRI). Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms. To my knowledge, this is the first report of a depressive patient who did not experience any seminal emission side effects during the first period of the drug’s use, but did experience involuntary seminal emission during defecation when taking Fluoxetine a year later.

Keywords: Fluoxetine, seminal emission, defecation



Benazzi F  (1995). Involuntary sperm emission with fluoxetine. Can. J. Psychiatry 40: 431.

Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F  (2001). Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients.  J. Clin. Psychiatry 3: 10-21.

Rosen RC, Lane RM, Menza M (1999). Effects of SSRIs on sexual function: a critical review.  J. Clin. Psychopharmacol. 19: 67-85.

van Puijenbroek EP, Meyboom RHB (1998). Semen-like urethral discharge during the use of mazindol.  Int. J. Eating Disorders. 24: 111-113.

Yoshida K, Higuchi H, Takahashi H, Shimizu T  (2004). Ejaculation After Defecation Without Orgasm Induced by Milnacipran.  J. Neuropsychiatry Clin. Neurosci. 16: 4.


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