Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
August 2014 Vol. 3(8), pp. 186-189
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Phytochemical Screening and Anti-hyperglycaemic Activity of Ethanolic Extract of Terminalia ivorensis A. Chev. Leaves on Albino Wistar Rats

Johnny, I. I1*, Ekong, N. J2 and Okon, J. E3.

1Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.
2Department of Biological Sciences, Faculty of Pure and Applied Sciences, Federal University Wukari, Taraba State, Nigeria.
3Department of Botany and Ecological Studies, Faculty of Science,  University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.

*Corresponding Author E-mail: joesplendid@yahoo.com

Accepted 28 July, 2014

Abstract

Phytochemical screening and anti-hyperglycaemic activity of ethanolic leaf extract of Terminalia ivorensis on alloxan induced wistar diabetic rats were investigated. Standard procedures were used for the evaluation. The median lethal dose (LD50) of the plant was determined intraperitoneally. Results of phytochemical screening of the ethanolic extract revealed the presence of alkoloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids. The LD50 of the leaf extract was 3464.10 mg/kg. Anti-hyperglycaemic results of the extract showed a significant (p<0.05) reduction in the blood glucose level (BGL) middle dose (692.82 mg/kg) at the six hours after intraperitoneal administration. The extract compared favourably with the standard drug (metformin: 100 mg/kg). This study has demonstrated the anti-hyperglycaemic potentials of Terminalia ivorensis leaf extract and thereby lends credence for its usage in herbal preparation for the treatment of diabetic patients in Akwa Ibom State.

Keywords: Terminalia ivorensis, phytochemical screening, hyperglycaemic, diabetes, albino rats, ethanolic extract, metformin.

 

Related Articles


Original Research Articles
Blessing M Onyegeme-Okerenta, Eugene N Onyeike and Favour Oke Esialekpe
Effect of ethanol leaf extract of Millettia aboensis on selected haematological indices of wistar albino rats
Glo. Adv. Res. J. Med. Med. Sci. July 2013 Vol: 2(1): - [Abstract] [Full Text - PDF] (597 KB)
Deleen Abd-ALWahab AL-Shukri, Mustafa G AL-Abbassi and Firas Younis AL-Doori
Effects of metformin and metformin in combination with omega-3 on newly diagnosed type 2 diabetic Iraqi patients
Glo. Adv. Res. J. Med. Med. Sci. October 2013 Vol: 2(1): - [Abstract] [Full Text - PDF] (261 KB)
Gabriel Manjarrez-Gutiérrez, Rocío Herrera-Márquez, Teresa Neri-Gómez and Jorge Hernández-Rodríguez
Serotonin levels in plasma and platelets of adolescents with type 1 diabetes
Glo. Adv. Res. J. Med. Med. Sci. September 2014 Vol: 3(9): - [Abstract] [Full Text - PDF] (289 KB)
Ejoba Raphael
Phytochemical constituents of some leaves extracts of Aloe vera and Azadirachta indica plant species
Glo. Adv. Res. J. Med. Med. Sci. May 2012 Vol: 1(2): - [Abstract] [Full Text - PDF] (150 KB)
Nadia M Al-Rouby and Shefaa M Gawish
Histological Study on the Possible Protective Effect of Nigella Sativa Oil on Experimentally Induced Hepatotoxicity in Albino Rats Treated with Sodium Valproate
Glo. Adv. Res. J. Med. Med. Sci. April 2013 Vol: 2(4): - [Abstract] [Full Text - PDF] (793 KB)
Review
Rashid M Ansari, Hassan Hosseinzadeh and Nicholas Zwar
Systematic Review of Type 2 diabetes self-management: focusing on the middle-aged population of rural area of Pakistan
Glo. Adv. Res. J. Med. Med. Sci. June 2016 Vol: 5(6): - [Abstract] [Full Text - PDF] (202 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Johnny II on Google Scholar
Johnny II on Pubmed
Ekong NJ on Google Scholar
Ekong NJ on Pubmed
Okon JE on Google Scholar
Okon JE on Pubmed

Statistics

Viewed 1295
Printed 266
Downloaded 1159
Powered By iPortal Works