Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
August 2014 Vol. 3(8), pp. 186-189
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Phytochemical Screening and Anti-hyperglycaemic Activity of Ethanolic Extract of Terminalia ivorensis A. Chev. Leaves on Albino Wistar Rats

Johnny, I. I1*, Ekong, N. J2 and Okon, J. E3.

1Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.
2Department of Biological Sciences, Faculty of Pure and Applied Sciences, Federal University Wukari, Taraba State, Nigeria.
3Department of Botany and Ecological Studies, Faculty of Science,  University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.

*Corresponding Author E-mail: joesplendid@yahoo.com

Accepted 28 July, 2014

Abstract

Phytochemical screening and anti-hyperglycaemic activity of ethanolic leaf extract of Terminalia ivorensis on alloxan induced wistar diabetic rats were investigated. Standard procedures were used for the evaluation. The median lethal dose (LD50) of the plant was determined intraperitoneally. Results of phytochemical screening of the ethanolic extract revealed the presence of alkoloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids. The LD50 of the leaf extract was 3464.10 mg/kg. Anti-hyperglycaemic results of the extract showed a significant (p<0.05) reduction in the blood glucose level (BGL) middle dose (692.82 mg/kg) at the six hours after intraperitoneal administration. The extract compared favourably with the standard drug (metformin: 100 mg/kg). This study has demonstrated the anti-hyperglycaemic potentials of Terminalia ivorensis leaf extract and thereby lends credence for its usage in herbal preparation for the treatment of diabetic patients in Akwa Ibom State.

Keywords: Terminalia ivorensis, phytochemical screening, hyperglycaemic, diabetes, albino rats, ethanolic extract, metformin.

 

Related Articles


Review
Rashid M Ansari, Hassan Hosseinzadeh and Nicholas Zwar
Systematic Review of Type 2 diabetes self-management: focusing on the middle-aged population of rural area of Pakistan
Glo. Adv. Res. J. Med. Med. Sci. June 2016 Vol: 5(6): - [Abstract] [Full Text - PDF] (202 KB)
Original Research Articles
Momoh AO, Adebolu TT and Ogundare AO
The effects of fermented Liqour and methanol extract of Beniseeds on the Biochemical and liver functioning parameters of Albino rats
Glo. Adv. Res. J. Med. Med. Sci. October 2012 Vol: 1(6): - [Abstract] [Full Text - PDF] (142 KB)
Gabriel Manjarrez-Gutiérrez, Teresa Neri-Gómez, Rocío Herrera-Márquez, José Antonio Mondragón-Herrera, Alfonso Boyzo-Montes de Oca and Jorge Hernandez-Rodríguez
Brain Serotonergic Disturbances Caused by Diabetes Mellitus are not Reversed by Insulin Treatment
Glo. Adv. Res. J. Med. Med. Sci. October 2015 Vol: 4(10): - [Abstract] [Full Text - PDF] (244 KB)
Mohamed Salah Elgendy
Histological Study on the Protective Effect of Stem Cells and ginger on Isoproterenol Induced Myocardial Infarction in Male Albino Rats
Glo. Adv. Res. J. Med. Med. Sci. December 2016 Vol: 5(12): - [Abstract] [Full Text - PDF] (4,004 KB)
Afaf S. Altalhi; Aziza M. Hassan; Shatha Dhaifallah Al-Harthi and Fatima Sulaiman Al-harbi
Wild Olive Leaf Extracts Up regulate Insulin-signaling Gene Expression in Diabetic mice
Glo. Adv. Res. J. Med. Med. Sci. April 2018 Vol: 7(4): - [Abstract] [Full Text - PDF] (281 KB)
Dina El-Kahky, Magdy Attia, Saadia M Easa, Nemat M. Awad and Eman A. Helmy
Biosynthesized of zinc oxide nanoparticles using Aspergillus terreus and their application as antitumor and antimicrobial activity
Glo. Adv. Res. J. Med. Med. Sci. March 2019 Vol: 8(3): - [Abstract] [Full Text - PDF] (1,543 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Johnny II on Google Scholar
Johnny II on Pubmed
Ekong NJ on Google Scholar
Ekong NJ on Pubmed
Okon JE on Google Scholar
Okon JE on Pubmed

Statistics

Viewed 2431
Printed 1921
Downloaded 1655
Powered By iPortal Works