Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
August 2014 Vol. 3(8), pp. 186-189
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Phytochemical Screening and Anti-hyperglycaemic Activity of Ethanolic Extract of Terminalia ivorensis A. Chev. Leaves on Albino Wistar Rats

Johnny, I. I1*, Ekong, N. J2 and Okon, J. E3.

1Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.
2Department of Biological Sciences, Faculty of Pure and Applied Sciences, Federal University Wukari, Taraba State, Nigeria.
3Department of Botany and Ecological Studies, Faculty of Science,  University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.

*Corresponding Author E-mail: joesplendid@yahoo.com

Accepted 28 July, 2014

Abstract

Phytochemical screening and anti-hyperglycaemic activity of ethanolic leaf extract of Terminalia ivorensis on alloxan induced wistar diabetic rats were investigated. Standard procedures were used for the evaluation. The median lethal dose (LD50) of the plant was determined intraperitoneally. Results of phytochemical screening of the ethanolic extract revealed the presence of alkoloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids. The LD50 of the leaf extract was 3464.10 mg/kg. Anti-hyperglycaemic results of the extract showed a significant (p<0.05) reduction in the blood glucose level (BGL) middle dose (692.82 mg/kg) at the six hours after intraperitoneal administration. The extract compared favourably with the standard drug (metformin: 100 mg/kg). This study has demonstrated the anti-hyperglycaemic potentials of Terminalia ivorensis leaf extract and thereby lends credence for its usage in herbal preparation for the treatment of diabetic patients in Akwa Ibom State.

Keywords: Terminalia ivorensis, phytochemical screening, hyperglycaemic, diabetes, albino rats, ethanolic extract, metformin.

 

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