Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
August 2014 Vol. 3(8), pp. 186-189
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Phytochemical Screening and Anti-hyperglycaemic Activity of Ethanolic Extract of Terminalia ivorensis A. Chev. Leaves on Albino Wistar Rats

Johnny, I. I1*, Ekong, N. J2 and Okon, J. E3.

1Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.
2Department of Biological Sciences, Faculty of Pure and Applied Sciences, Federal University Wukari, Taraba State, Nigeria.
3Department of Botany and Ecological Studies, Faculty of Science,  University of Uyo, P.M.B. 1017, Uyo. Akwa Ibom State - Nigeria.

*Corresponding Author E-mail: joesplendid@yahoo.com

Accepted 28 July, 2014

Abstract

Phytochemical screening and anti-hyperglycaemic activity of ethanolic leaf extract of Terminalia ivorensis on alloxan induced wistar diabetic rats were investigated. Standard procedures were used for the evaluation. The median lethal dose (LD50) of the plant was determined intraperitoneally. Results of phytochemical screening of the ethanolic extract revealed the presence of alkoloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids. The LD50 of the leaf extract was 3464.10 mg/kg. Anti-hyperglycaemic results of the extract showed a significant (p<0.05) reduction in the blood glucose level (BGL) middle dose (692.82 mg/kg) at the six hours after intraperitoneal administration. The extract compared favourably with the standard drug (metformin: 100 mg/kg). This study has demonstrated the anti-hyperglycaemic potentials of Terminalia ivorensis leaf extract and thereby lends credence for its usage in herbal preparation for the treatment of diabetic patients in Akwa Ibom State.

Keywords: Terminalia ivorensis, phytochemical screening, hyperglycaemic, diabetes, albino rats, ethanolic extract, metformin.

 

Related Articles


Original Research Article
Sandra Alicia Reza-Lopez, Blanca Estela Sánchez-Ramírez, Daniela Sarahí Gutiérrez-Torres, Mariela Rodríguez-Salinas, Martha Grisell Ortega-Valerio, Dora Virginia Chávez-Corral and Margarita Levario-Carrillo
Expression of glucose transporters in placenta from macrosomic infants
Glo. Adv. Res. J. Med. Med. Sci. October 2014 Vol: 3(10): - [Abstract] [Full Text - PDF] (129 KB)
Case Report
Lorenzo Andreani, Paolo Domenico Parchi, Nicola Piolanti and Michele Lisanti
Finger foot phalanx metastasis revealing occult pulmonary adenocarcinoma: A case report and review of the literature
Glo. Adv. Res. J. Med. Med. Sci. April 2013 Vol: 2(4): - [Abstract] [Full Text - PDF] (442 KB)
Original Research Articles
Azza A El-Masry
Potential Therapeutic Effect of Curcuma longa on Streptozotocin Induced Diabetic rats
Glo. Adv. Res. J. Med. Med. Sci. May 2012 Vol: 1(4): - [Abstract] [Full Text - PDF] (155 KB)
Ali Taha A Hassan, Hossam El-Din M Omar, Nagwa M Elsawi and Amira M Ahmed
Evaluation of serum cortisol, growth and thyroid hormones and its relation with lipolysis in non-diabetic obese and diabetic obese subjects attending Sohag Governorate, Egypt
Glo. Adv. Res. J. Med. Med. Sci. April 2016 Vol: 5(4): - [Abstract] [Full Text - PDF] (156 KB)
Awe JAA, Ugwi V and Omon EH
Inguinal hernias: analysis of incidence, diagnosis and management of 172 consecutive adult cases at Igbinedion university teaching hospital Okada
Glo. Adv. Res. J. Med. Med. Sci. July 2014 Vol: 3(7): - [Abstract] [Full Text - PDF] (366 KB)
Maimoona Mushtaq Ahmed
Clinical presentation of diabetic emergencies in university hospital
Glo. Adv. Res. J. Med. Med. Sci. October 2014 Vol: 3(10): - [Abstract] [Full Text - PDF] (380 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Johnny II on Google Scholar
Johnny II on Pubmed
Ekong NJ on Google Scholar
Ekong NJ on Pubmed
Okon JE on Google Scholar
Okon JE on Pubmed

Statistics

Viewed 1694
Printed 331
Downloaded 1343
Powered By iPortal Works